Biosynthesis of the anti‐lipid‐microdomain sphingoid base 4,14‐sphingadiene by the ceramide desaturase FADS3

DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans

(2019) Gergely Karsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood

(2018) Xinyu Liu et al.   CLINICAL CHEMISTRY

Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals

(2018) Mai Edagawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

(2017) Megumi Sawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum

(2017) Takuya Kitamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fads3 modulates docosahexaenoic acid in liver and brain

(2017) Ji Yao Zhang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

(2017) Yusuke Ohno et al.   Nature Communications

Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification

(2016) Jace W. Jones et al.   BIOMEDICAL CHROMATOGRAPHY

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

(2016) Takayuki Sassa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

(2016) Akio Kihara   PROGRESS IN LIPID RESEARCH

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

(2016) L. Filipe C. Castro et al.   PROGRESS IN LIPID RESEARCH

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

(2015) Takuya Kitamura et al.   BIOCHEMICAL JOURNAL

Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors

(2015) Mariona Rabionet et al.   HUMAN MOLECULAR GENETICS

Lipidomic “Deep Profiling”: An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids

(2014) Pradeep Narayanaswamy et al.   ANALYTICAL CHEMISTRY

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

(2014) Patrick Essletzbichler et al.   GENOME RESEARCH

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

(2014) Natsuki Kondo et al.   Nature Communications

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

(2013) Akio Kihara   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The complexity of sphingolipid biosynthesis in the endoplasmic reticulum

(2013) Rotem Tidhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sphingosine 1-phosphate signalling

(2013) K. Mendelson et al.   DEVELOPMENT

Trans-vaccenate is Δ13-desaturated by FADS3 in rodents

(2013) Vincent Rioux et al.   JOURNAL OF LIPID RESEARCH

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Profiling and Characterizing Skin Ceramides Using Reversed-Phase Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry

(2011) Ruben t’Kindt et al.   ANALYTICAL CHEMISTRY

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats

(2010) Tatsuya Sugawara et al.   JOURNAL OF LIPID RESEARCH

Glycan-based high-affinity ligands for toxins and pathogen receptors

(2010) Ashish A. Kulkarni et al.   MEDICINAL RESEARCH REVIEWS

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Glycosphingolipids-Nature, Function, and Pharmacological Modulation

(2009) Tom Wennekes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids

(2009) Junko Ishikawa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues

(2009) Frédérique Pédrono et al.   JOURNAL OF LIPID RESEARCH

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

(2008) C MAO   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Thematic Review Series: Sphingolipids.Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

(2008) Sarah T. Pruett et al.   JOURNAL OF LIPID RESEARCH