ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pheophorbide A: Fluorescent Bcrp substrate to measure oral drug-drug interactions in real time in vivo

(2018) Kazuto Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

Obstacles to Brain Tumor Therapy: Key ABC Transporters

(2017) Juwina Wijaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies

(2017) Ricardo J. Ferreira et al.   Scientific Reports

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

(2017) Zhao Wang et al.   eLife

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

(2016) Nagarajan Vaidehi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6

(2016) Yu Fukuda et al.   Nature Communications

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

(2015) Marie Morfouace et al.   CANCER RESEARCH

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins

(2015) Friedrich B M Reinhard et al.   NATURE METHODS

Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach

(2014) Suneet Shukla et al.   MOLECULAR PHARMACEUTICS

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

ABC transporters and their role in nucleoside and nucleotide drug resistance

(2012) Yu Fukuda et al.   BIOCHEMICAL PHARMACOLOGY

Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2

(2012) Atsushi Hosomi et al.   PLoS One

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

(2011) S. Nagai et al.   CANCER RESEARCH

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds

(2008) J. Enokizono et al.   DRUG METABOLISM AND DISPOSITION

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

Conformational thermostabilization of the  1-adrenergic receptor in a detergent-resistant form

(2008) M. J. Serrano-Vega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA