Molecular model of the ferroportin intracellular gate and implications for the human iron transport cycle and hemochromatosis type 4A

Emerging Diversity in Lipid–Protein Interactions

(2019) Valentina Corradi et al.   CHEMICAL REVIEWS

Characterization of three novel pathogenic SLC40A1 mutations and genotype/phenotype correlations in 7 Italian families with type 4 hereditary hemochromatosis

(2018) Silvia Majore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Combining theoretical and experimental data to decipher CFTR 3D structures and functions

(2018) Brice Hoffmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The SLC40A1 R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism

(2018) Chandran Ka et al.   HAEMATOLOGICA

In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways

(2018) Leonard P. Heinz et al.   Scientific Reports

The SLC40A1 R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism

(2018) Chandran Ka et al.   HAEMATOLOGICA

Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

(2018) Chandrika N. Deshpande et al.   Nature Communications

Loss-of-function ferroportin disease: novel mechanistic insights and unanswered questions

(2018) L. Tom Vlasveld et al.   HAEMATOLOGICA

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Hepcidin in the diagnosis of iron disorders

(2016) D. Girelli et al.   BLOOD

Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis

(2016) Yongwei Wang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

CHARMM-GUI 10 years for biomolecular modeling and simulation

(2016) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

A bacterial homologue of the human iron exporter ferroportin

(2015) Maria Carmela Bonaccorsi di Patti et al.   FEBS LETTERS

Gating Topology of the Proton-Coupled Oligopeptide Symporters

(2015) Philip W. Fowler et al.   STRUCTURE

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

(2015) Reiya Taniguchi et al.   Nature Communications

A structural model of human ferroportin and of its iron binding site

(2014) Maria C. Bonaccorsi di Patti et al.   FEBS Journal

Comprehensive functional annotation of 18 missense mutations found in suspected hemochromatosis type 4 patients

(2014) I. Callebaut et al.   HUMAN MOLECULAR GENETICS

Familie mit ausgeprägter Hyperferritinämie als Folge einer Hämochromatose Typ 4 (Ferroportin-Krankheit)

(2014) K. Muehlenberg et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Structure-Function Analysis of the Human Ferroportin Iron Exporter (SLC40A1): Effect of Hemochromatosis Type 4 Disease Mutations and Identification of Critical Residues

(2013) Gérald Le Gac et al.   HUMAN MUTATION

Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

(2013) Lukas S. Stelzl et al.   JOURNAL OF MOLECULAR BIOLOGY

Alternating access mechanism in the POT family of oligopeptide transporters

(2012) Nicolae Solcan et al.   EMBO JOURNAL

Clinicopathological study of Japanese patients with genetic iron overload syndromes

(2012) Ai Hattori et al.   PATHOLOGY INTERNATIONAL

Optimization of the CHARMM Additive Force Field for DNA: Improved Treatment of the BI/BII Conformational Equilibrium

(2011) Katarina Hart et al.   Journal of Chemical Theory and Computation

A novel missense mutation c.470 A>C (p.D157A) in the SLC40A1 gene as a cause of ferroportin disease in a family with hyperferritinaemia

(2010) Khalid Saja et al.   BRITISH JOURNAL OF HAEMATOLOGY

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders

(2010) Yoshibumi Kaneko et al.   JOURNAL OF GASTROENTEROLOGY

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype

(2009) Daniel F. Wallace et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Analysis of SLC40A1 gene at the mRNA level reveals rapidly the causative mutations in patients with hereditary hemochromatosis type IV

(2007) Matthaios Speletas et al.   BLOOD CELLS MOLECULES AND DISEASES