Article
Biochemistry & Molecular Biology
Paola Lasso, Laura Rojas, Cindy Arevalo, Claudia Uruena, Natalia Murillo, Susana Fiorentino
Summary: In this study, it was found that the natural products Anamu-SC and P2Et have different mechanisms of antitumor activity. Anamu-SC reduces tumor growth in a murine mammary carcinoma model, while P2Et has no effect on melanoma. Both extracts decrease IL-10 levels in melanoma, but only P2Et increases TNF-α and IFN-γ levels. The extracts also have different effects on immune cell infiltration and the CD8+/Treg ratio.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hung Guo, Shiou-Yue Wang, Chieh-Han Chung, Min -Yi Shih, Wen-Chin Li, Pei-Chung Chen, Shih-Yu Lee, Simon Hsia
Summary: This study evaluated the effects of selenium on triple-negative breast cancer cells and found that selenium can induce apoptosis, inhibit cell cycle, stemness, tumor metastasis, and immune checkpoint molecules. Similar effects were observed in human breast cancer cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hye Won Lee, Hee Seung Seo, Seon-Yong Yeom, Se-Na Kim, Cho Rim Kim, Dae-Hwan Park, Wooram Park, Young Bin Choy, Chun Gwon Park, Seong Il Seo
Summary: The use of CZ-loaded PLGA nanoparticles as an adjuvant therapy for post-nephrectomy metastasis shows promising results in inhibiting tumor growth and metastasis in renal cell carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Manman Xie, Yuancheng Li, Yaolin Xu, Zhaobin Zhang, Bing Ji, Joshua B. Jones, Zi Wang, Hui Mao
Summary: This study demonstrates the significant advantage of sub-5 nm magnetic iron oxide nanoparticles in targeted therapy of brain tumors. These ultrafine nanoparticles can cross the blood-brain barrier and blood-tumor barrier due to their small core size, leading to efficient accumulation within the tumor. Additionally, sub-5 nm nanoparticles can be visualized using molecular imaging techniques for the detection of brain tumors.
ACS APPLIED NANO MATERIALS
(2022)
Article
Oncology
Sarah Kraus, Raz Khandadash, Raphael Hof, Abraham Nyska, Ekaterina Sigalov, Moshe Eltanani, Pazit Rukenstein, Ricarina Rabinovitz, Rana Kassem, Adam Antebi, Ofer Shalev, Moshe Cohen-Erner, Glenwood Goss, Arnoldo Cyjon
Summary: SaNPs show potential safety and efficacy in cancer treatment, accumulating in tumors and delivering thermal energy to malignant cells, demonstrating inhibition of tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Jae In Jung, Hyun Sook Lee, Jaehak Lee, Eun Ji Kim
Summary: The ethanol extract of peanut sprout tea (PSTE) inhibits breast cancer growth and metastasis by blocking the crosstalk between cancer cells and macrophages. PSTE also prevents the differentiation of macrophages into the M2 subtype.
NUTRITION RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Syed N. A. Bukhari, Michael A. Tandiary, Mohammad M. Al-Sanea, Mohamed A. Abdelgawad, Chin F. Chee, Muhammad A. Hussain
Summary: This review provides a comprehensive survey of small organic molecules for LIM kinase inhibitors, including the discovery, SAR study results, and synthesis of these inhibitors.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Hui Nee Geo, Dharmani Devi Murugan, Zamri Chik, Anwar Norazit, Yiing Yee Foo, Bey Fen Leo, Yin Yin Teo, Sharifah Zamiah Syed Binti Syed Abdul Kadir, Yinghan Chan, Hann Juang Chai, Maria Medel, Nor Azizan Abdullah, Edward J. Johns, Maria J. Vicent, Lip Yong Chung, Lik Voon Kiew
Summary: This article reviews the current status and future trajectories of renal nanomedicine research for the management of acute kidney injury (AKI). The use of nanosized drug carriers (NDCs) for the delivery of reno-protective agents is evaluated, with a focus on improving renal tissue targeting selectivity and efficacy. The need to identify accumulation sites of NDCs in renal tissues during in vivo assessments is highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Wen Shang Saw, Theebaa Anasamy, Thu Thi Anh Do, Hong Boon Lee, Chin Fei Chee, Umit Isci, Misni Misran, Fabienne Dumoulin, Wu Yi Chong, Lik Voon Kiew, Toyoko Imae, Lip Yong Chung
Summary: In this study, the researchers improved the efficiency of photothermal-photodynamic cancer treatment by using PAMAM dendrimers as spacers between the photosensitizer-gold nanoparticles (PS-AuNP) system. They found that the PS-PAMAM-confeito-AuNPs demonstrated better cancer cell-killing efficacy, higher phototoxicity, and selective tumor accumulation effect compared to directly conjugated photosensitizers.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hui Shan Liew, Chun-Wai Mai, Mohd Zulkefeli, Thiagarajan Madheswaran, Lik Voon Kiew, Lesley Jia Wei Pua, Ling Wei Hii, Wei Meng Lim, May Lee Low
Summary: With a 5-year survival rate of less than 10%, pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Gemcitabine is commonly used as the first-line treatment, but its efficacy is often reduced due to poor cellular penetration and tumor resistance. This study explores the synergistic use of a transition metal complex photosensitizer, Re(I) bisquinolinyl complex, and gemcitabine against PDAC. The encapsulation of these compounds into liquid crystalline nanoparticles (LCNPs) was found to enhance their therapeutic efficiency. The results suggest the potential use of this combination therapy and the importance of nano-formulation in PDAC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Nurhaliza Wati Mekzali, Cheok Wui Chee, Iskandar Abdullah, Yean Kee Lee, Nurshamimi Nor Rashid, Vannajan Sanghiran Lee, Rozana Othman, Najihah Mohd Hashim, Chin Fei Chee
Summary: This study investigates the effects of alkoxy chain length and 1-hydroxy group on the activity of 2-bromoalkoxyanthraquinones in colorectal cancer. Results suggest that 2-bromoalkoxyanthraquinones with the 1-hydroxy group exhibit higher anticancer activity. Compound 6b, with a C-3 alkoxy chain, shows promising antiproliferation activity against HCT116 cells and high selectivity for HCT116 over CCD841 CoN cells.
MEDICINAL CHEMISTRY
(2023)
Article
Acoustics
Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin, Chia -Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni Misran, Lip Yong Chung, Dar-Bin Shieh, Lik Voon Kiew, Chia-Ching Chang, Yin Yin Teo
Summary: Gold nanorods coated with alginate (AuNRsALG) are found to be promising nanosonosensitisers for sonodynamic therapy (SDT) due to their enhanced singlet oxygen generation and efficient cancer cell killing effect, primarily through apoptosis.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cheng Hong Yap, Abdul Qaiyum Ramle, See Khai Lim, Avinash Rames, Sun Tee Tay, Sek Peng Chin, Lik Voon Kiew, Edward R. T. Tiekink, Chin Fei Chee
Summary: Staphylococcus aureus is an adaptable pathogen that can form biofilms and generate persister cells. In this study, a new compound was synthesized and found to have promising antibiofilm activities against S. aureus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Melbha Starlin Chellathurai, Chung Lip Yong, Zarif Mohamed Sofian, Shariza Sahudin, Najihah Binti Mohd Hasim, Syed Mahmood
Summary: Chitosan is a natural polysaccharide that is biodegradable, bioadhesive, and biocompatible. It has been extensively studied for oral insulin drug delivery systems. Electrostatic interaction between chitosan and insulin leads to the formation of self-assembled nanoparticles, which can protect insulin from degradation and improve intestinal uptake. Functionalized chitosan nanoparticles also offer opportunities for targeted and prolonged delivery. This review provides a comprehensive guide for formulating stable insulin-chitosan nanoparticles using mild ionic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Aiman Irfan Ibrahim, Rozana Othman, Chin Fei Chee, Faisalina Ahmad Fisol
Summary: Targeting folate receptors is a potential solution for addressing low tumor selectivity in conventional chemotherapeutics. Folate-functionalized nanoparticle drug delivery systems show promise due to their advantages, although none have entered clinical trials. In vitro evidence supports their efficacy compared to non-targeting carriers and free drug formulations. However, in vivo biodistribution studies reveal issues with rapid liver uptake and reduced tumor uptake, potentially influenced by the expression of folate receptor β by activated macrophages in the liver, as well as the route of administration and tumor location. Generalizing nanoparticles reported in various publications is challenging due to different formulations, lack of characterization, and experimental settings, making it difficult to determine the accurate factors influencing targeting effectiveness.
Correction
Chemistry, Applied
Theebaa Anasamy, Chin Fei Chee, Yuen Fei Wong, Choon Han Heh, Lik Voon Kiew, Hong Boon Lee, Lip Yong Chung
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
R. A. H. W. Chua, S. K. Lim, C. F. Chee, S. P. Chin, L. V. Kiew, K. S. Sim, S. T. Tay
Summary: Sutures are vital in wound healing and surgical interventions, but can also lead to severe surgical site infections. The efficacy of traditional antimicrobial sutures may be compromised by resistant bacterial strains, highlighting the need for alternative approaches to their development.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)