Review
Biochemistry & Molecular Biology
Marcus Mkhatshwa, Joshua Mamolatelo Moremi, Katlego Makgopa, Amanda-Lee Ezra Manicum
Summary: The application of magnetic nanomedicine as a new tool in cancer treatment research has gained significant attention. MNPs possess unique characteristics, making them suitable for cancer diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Wen-Wen Feng, Bin-Fa Liang, Bai-Hua Chen, Qi-Yan Liu, Zheng-Yin Pan, Ying-Ju Liu, Liang He
Summary: Organelle-targeted photodynamic therapy (PDT) using a tricarbonyl Re(I) complex (Re-BDP) was shown to effectively kill cancer cells by generating toxic reactive oxygen species (ROS) in the endoplasmic reticulum (ER). Re-BDP exhibited strong absorbance and high singlet oxygen quantum yield, and preferentially accumulated in the ER. Upon visible light irradiation, Re-BDP showed high phototoxicity and induced caspase-dependent apoptosis accompanied by mitochondrial dysfunction. This study highlights the potential of developing efficient organelle-targeted phototherapeutic agents by conjugating metal complexes and organic chromophores.
Article
Chemistry, Inorganic & Nuclear
Liam J. J. Stephens, Elena Dallerba, Jenisi T. A. Kelderman, Aviva Levina, Melissa V. V. Werrett, Peter A. A. Lay, Massimiliano Massi, Philip C. C. Andrews
Summary: This study synthesized and characterized twelve Re(i) tricarbonyl diimine complexes with thiotetrazolato ligands. The tetrazolato ligand can bind to the Re(i) center through either the S atom or the N atom, with most complexes being bound to the N atom. In solution, the complexes exist as an equilibrating mixture of linkage isomers. The complexes exhibit photoluminescent properties, with emission wavelengths dependent on the nature of the diimine ligand.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Ahmed M. Mansour
Summary: In this study, a series of mono- and binuclear triazolate complexes were synthesized through catalyst-free [3+2] cycloaddition coupling, with the isomerization process from the kinetically formed N(1) bound triazolate isomer to the N(2) analogue successfully evidenced. The solvatochromism properties of these complexes were assessed using UV/Vis spectroscopy and time dependent density functional theory calculations. Additionally, the potential antimicrobial activity of the free ligands and their tricarbonyl triazolato Re(i) complexes against various bacterial and fungal pathogens was preliminarily evaluated.
Article
Pharmacology & Pharmacy
Muhammed Awad, Timothy J. Barnes, Nicky Thomas, Paul Joyce, Clive A. Prestidge
Summary: This study investigated the use of gallium protoporphyrin liquid crystalline lipid nanoparticles (GaPP-LCNP) as a photosensitizer in antimicrobial photodynamic therapy (aPDT). The results showed that GaPP-LCNP significantly enhanced the antibacterial activity and effectively reduced the viability of both planktonic and biofilm forms of P. aeruginosa. The findings suggest that GaPP-LCNP is a promising platform for the photodynamic inactivation of antibiotic resistant bacterial infections.
Article
Infectious Diseases
Muhammed Awad, Timothy J. Barnes, Clive A. Prestidge
Summary: Lipid liquid crystalline nanoparticles (LCNPs) are effective nanocarriers for delivering antimicrobials, but they are not stable in aqueous dispersions. In this study, lyophilization was used to produce dry LCNPs loaded with a hydrophobic antimicrobial compound. The rehydrated LCNPs retained their structure and antimicrobial activity. This research demonstrates the potential of lyophilization to enhance the application of LCNPs as an antimicrobial delivery system.
Article
Chemistry, Multidisciplinary
Mabu L. Matlou, Hitler Louis, Destiny E. Charlie, Ernest C. Agwamba, Ismail O. Amodu, Vuyelwa J. Tembu, Amanda-Lee E. Manicum
Summary: In this study, the unique properties of metal-based rhenium tricarbonyl complexes as effective anticancer drugs were explored using density functional theory (DFT) and in silico molecular docking approaches. The structural characterization and stability of the complexes were investigated. The results showed that these complexes exhibited good anticancer activity, with strong binding affinity to key proteins involved in cancer cell regulation.
Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Hyeonglim Seo, Seth M. Cohen
Summary: Re(i) tricarbonyl complexes are of interest due to their attractive properties, with multinuclear assemblies offering greater structural diversity. Despite synthesis challenges, tetranuclear Re(i) tricarbonyl metallacycles with square geometry were successfully prepared using a tetrazole-based ligand, demonstrating the potential for producing similar structures with suitable ligands.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Mariano Soba, Gonzalo Scalese, Federico Casuriaga, Nicolas Perez, Nicolas Veiga, Gustavo A. Echeverria, Oscar E. Piro, Ricardo Faccio, Leticia Perez-Diaz, Gilles Gasser, Ignacio Machado, Dinorah Gambino
Summary: In this study, multifunctional Re(I) tricarbonyl compounds were designed as potential antichagasic drugs. These compounds showed activity against T. cruzi and demonstrated good selectivity towards the parasite compared to mammalian cells. The mechanism of action and physicochemical properties of these compounds were also investigated, showing promising potential for further drug development.
DALTON TRANSACTIONS
(2023)
Article
Nanoscience & Nanotechnology
Keegan Guidolin, Lili Ding, Juan Chen, Brian C. Wilson, Gang Zheng
Summary: The study demonstrates that Porphysome nanoparticles have significant tumor ablative effects at different doses and show similar tumor growth suppression to clinical photosensitizers.
Article
Chemistry, Multidisciplinary
Girgis Obaid, Shazia Bano, Hanna Thomsen, Susan Callaghan, Nimit Shah, Joseph W. R. Swain, Wendong Jin, Xiadong Ding, Colin G. Cameron, Sherri A. McFarland, Juwell Wu, Mark Vangel, Svetla Stoilova-McPhie, Jie Zhao, Mari Mino-Kenudson, Charles Lin, Tayyaba Hasan
Summary: Desmoplasia, a characteristic of pancreatic ductal adenocarcinoma (PDAC), poses barriers to treatment and affects patient outcomes. This study demonstrates a novel targeted liposomal therapy that combines photodynamic and chemotherapeutic effects while also remediating desmoplasia. The results show significant inhibition of tumor growth and improved survival, highlighting the potential of this therapy in extending the lives of PDAC patients.
Review
Chemistry, Inorganic & Nuclear
Binoy Kar, Utpal Das, Nilmadhab Roy, Priyankar Paira
Summary: Organelle specificity is crucial for the development of efficient and selective drugs with reduced side effects. Photodynamic therapy (PDT) has emerged as a selective treatment for cancer that minimizes damage to normal cells. This article showcases the potential of metal complexes, particularly ruthenium (II), iridium (III), and rhenium (I) complexes, in targeting specific organelles for PDT.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Sabrina S. Hafiz, Marvin Xavierselvan, Sumeyra Gokalp, Daniela Labadini, Sebastian Barros, Jeanne Duong, Michelle Foster, Srivalleesha Mallidi
Summary: The study presents a new liquid metal nanoplatform for cancer therapy, demonstrating high cellular uptake, targeting efficiency, and intracellular ROS generation of EGaPs. The near-infrared light activation of EGaPs showed potential to effectively eliminate cancer cells, making them a promising vehicle for photodynamic therapy. In vivo studies also showed tumor regression and higher necrosis compared to the control group, highlighting the potential of EGaPs for enhanced cancer therapy.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Ajay S. Sharma, N. Vaibhavi, Binoy Kar, Utpal Das, Priyankar Paira
Summary: Metal complexes, especially rhenium-based complexes, have attracted global interest as potential cancer therapeutics due to their ability to detect and annihilate cancer cells.
Article
Chemistry, Inorganic & Nuclear
Miles S. Capper, Alejandra Enriquez Garcia, Barry Lai, Baiwen O. Wang, Benjamin S. Gelfand, Carrie S. Shemanko, Farideh Jalilehvand
Summary: Research compared the cytotoxicity and cellular uptake of two Re(i) compounds, finding that replacement of the aqua ligand with thiosulfate reduced toxicity by potentially disrupting cellular entry pathways. Thiosulfate could have a chemoprotective effect similar to cisplatin against diimine fac-Re(CO)(3) complexes.
DALTON TRANSACTIONS
(2021)
Article
Oncology
Phei San Lai, Syed Muhammad Usama, Lik-Voon Kiew, Hong Boon Lee, Lip Yong Chung, Kevin Burgess, Chin Siang Kue
Summary: This study demonstrates the potential of hapten-based pre-immunization combined with cancer receptor labeling to elicit antibody-dependent cellular phagocytosis (ADCP) for improved immunotherapy of cancers expressing TrkC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Stephanie Sally Fong, Yiing Yee Foo, Wen Shang Saw, Bey Fen Leo, Yin Yin Teo, Ivy Chung, Boon Tong Goh, Misni Misran, Toyoko Imae, Chia-Ching Chang, Lip Yong Chung, Lik Voon Kiew
Summary: This study demonstrates the use of a chitosan-coated-poly(lactic-co-glycolic acid) (C-PLGA) nanocarrier to improve the delivery and efficacy of an antimetastatic agent called Stattic. The Stattic-entrapped C-PLGA nanoparticles showed enhanced anti-cell migration potency in vitro and tumor growth suppression in vivo, suggesting the potential of C-PLGA nanocarrier in improving cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wei Khang Gan, Hui Shan Liew, Lesley Jia Wei Pua, Xiao Ying Ng, Kar Wai Fong, Siew Lee Cheong, Yun Khoon Liew, May Lee Low
Summary: This study tested the antibacterial activity of two ligands and their copper(II) complexes, and their combination with polymyxin B and PA beta N against various bacteria. The results showed that the copper(II) complexes exhibited significant antibacterial activity and exerted synergistic effects when combined with polymyxin B and PA beta N. Molecular docking investigations revealed the binding interactions of the copper(II) complexes with the binding pockets of bacteria efflux pumps.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Hui Nee Geo, Dharmani Devi Murugan, Zamri Chik, Anwar Norazit, Yiing Yee Foo, Bey Fen Leo, Yin Yin Teo, Sharifah Zamiah Syed Binti Syed Abdul Kadir, Yinghan Chan, Hann Juang Chai, Maria Medel, Nor Azizan Abdullah, Edward J. Johns, Maria J. Vicent, Lip Yong Chung, Lik Voon Kiew
Summary: This article reviews the current status and future trajectories of renal nanomedicine research for the management of acute kidney injury (AKI). The use of nanosized drug carriers (NDCs) for the delivery of reno-protective agents is evaluated, with a focus on improving renal tissue targeting selectivity and efficacy. The need to identify accumulation sites of NDCs in renal tissues during in vivo assessments is highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Wen Shang Saw, Theebaa Anasamy, Thu Thi Anh Do, Hong Boon Lee, Chin Fei Chee, Umit Isci, Misni Misran, Fabienne Dumoulin, Wu Yi Chong, Lik Voon Kiew, Toyoko Imae, Lip Yong Chung
Summary: In this study, the researchers improved the efficiency of photothermal-photodynamic cancer treatment by using PAMAM dendrimers as spacers between the photosensitizer-gold nanoparticles (PS-AuNP) system. They found that the PS-PAMAM-confeito-AuNPs demonstrated better cancer cell-killing efficacy, higher phototoxicity, and selective tumor accumulation effect compared to directly conjugated photosensitizers.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Yin Zhuang Ng, Kong Wai Tan, Lip Yong Chung, Fatimah Salim, May Lee Low, Ing Hong Ooi, Foo Win Yip, Chew Hee Ng
Summary: Metal complexes functionalized on gold nanoparticles have been investigated in this study. The conjugate formed by zinc(II) Schiff base complex and gold nanoparticles exhibits high cytotoxicity against breast and colon cancer cells, as well as selective proteasome inhibition against Plasmodium falciparum.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Cheong-Weng Ooi, May Lee Low, Waldo Udos, Kok-Sing Lim, Harith Ahmad
Summary: A novel Schiff base functionalized tilted fiber Bragg grating (TFBG) is developed for the rapid detection of Copper ions in aqueous solutions. The proposed sensor offers higher sensitivity, a lower limit of detection, and less susceptibility to refractive index noise compared to conventional TFBGs.
OPTICAL FIBER TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Himshikha Sharma, Shweta Chaudhary, Sonam Nirwan, Rita Kakkar, HuiShan Liew, May-Lee Low, Chun-Wai Mai, Ling-Wei Hii, Chee-Onn Leong, Marilyn Daisy Milton
Summary: A series of dicationic N, N'-disubstituted benzimidazolium salts with Br- and PF6- as the counter anions were synthesized, showing selective turn-off fluorescence response toward Fe3+ ions in aqueous solution and synergism with doxorubicin in combinatorial treatment of breast cancer cells. Molecular docking studies revealed the binding affinity of one of the salts with checkpoint kinase 2 protein.
Article
Acoustics
Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin, Chia -Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni Misran, Lip Yong Chung, Dar-Bin Shieh, Lik Voon Kiew, Chia-Ching Chang, Yin Yin Teo
Summary: Gold nanorods coated with alginate (AuNRsALG) are found to be promising nanosonosensitisers for sonodynamic therapy (SDT) due to their enhanced singlet oxygen generation and efficient cancer cell killing effect, primarily through apoptosis.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cheng Hong Yap, Abdul Qaiyum Ramle, See Khai Lim, Avinash Rames, Sun Tee Tay, Sek Peng Chin, Lik Voon Kiew, Edward R. T. Tiekink, Chin Fei Chee
Summary: Staphylococcus aureus is an adaptable pathogen that can form biofilms and generate persister cells. In this study, a new compound was synthesized and found to have promising antibiofilm activities against S. aureus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Adilet Beishenaliev, Yean Leng Loke, Sook Jing Goh, Hui Nee Geo, Malar Mugila, Misni Misran, Lip Yong Chung, Lik Voon Kiew, Steve Roffler, Yin Yin Teo
Summary: Monospecific antibodies have limitations in delivering drugs to tumors with multiple epitopes, while bispecific antibodies provide a promising alternative by simultaneously targeting two distinct antigens or epitopes. This review discusses the roles of bispecific antibodies in enhancing the internalization and intracellular trafficking of drug-conjugated antibodies and facilitating the delivery of drug-encapsulating nanoconstructs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Correction
Chemistry, Applied
Theebaa Anasamy, Chin Fei Chee, Yuen Fei Wong, Choon Han Heh, Lik Voon Kiew, Hong Boon Lee, Lip Yong Chung
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
R. A. H. W. Chua, S. K. Lim, C. F. Chee, S. P. Chin, L. V. Kiew, K. S. Sim, S. T. Tay
Summary: Sutures are vital in wound healing and surgical interventions, but can also lead to severe surgical site infections. The efficacy of traditional antimicrobial sutures may be compromised by resistant bacterial strains, highlighting the need for alternative approaches to their development.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)