Dravet syndrome: Treatment options and management of prolonged seizures

Treatment Strategies for Dravet Syndrome

(2018) Kelly G. Knupp et al.   CNS DRUGS

Stiripentol efficacy and safety in Dravet syndrome: a 12-year observational study

(2018) Kenneth A Myers et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Influence of contraindicated medication use on cognitive outcome in Dravet syndrome and age at first afebrile seizure as a clinical predictor in SCN1A -related seizure phenotypes

(2018) Iris M. de Lange et al.   EPILEPSIA

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

(2018) Orrin Devinsky et al.   NEUROLOGY

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prospective study of the efficacy of a ketogenic diet in 20 patients with Dravet syndrome

(2018) Ni Yan et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome

(2018) Bláthnaid McCoy et al.   Annals of Clinical and Translational Neurology

Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior

(2017) Kristine Rømer Thomsen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel

(2017) Elaine C. Wirrell et al.   PEDIATRIC NEUROLOGY

Fatal Cerebral Edema With Status Epilepticus in Children With Dravet Syndrome: Report of 5 Cases

(2017) Kenneth A. Myers et al.   PEDIATRICS

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish

(2017) Jo Sourbron et al.   Frontiers in Pharmacology

Five-year extended follow-up status of 10 patients with Dravet syndrome treated with fenfluramine

(2016) Berten Ceulemans et al.   EPILEPSIA

Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy

(2015) Alexandra L. Geffrey et al.   EPILEPSIA

A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus

(2015) Eugen Trinka et al.   EPILEPSIA

Efficacy and tolerability of the ketogenic diet in Dravet syndrome – Comparison with various standard antiepileptic drug regimen

(2015) Anastasia Dressler et al.   EPILEPSY RESEARCH

Lamotrigine can be beneficial in patients with Dravet syndrome

(2014) Linda Dalic et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The case for medical marijuana in epilepsy

(2014) Edward Maa et al.   EPILEPSIA

Long-term course of Dravet syndrome: A study from an epilepsy center in Japan

(2014) Rumiko Takayama et al.   EPILEPSIA

Stiripentol in Dravet syndrome: Results of a retrospective U.S. study

(2013) Elaine C. Wirrell et al.   EPILEPSIA

Polytherapy with stiripentol: Consider more than just metabolic interactions

(2013) David D. Mott et al.   EPILEPSY & BEHAVIOR

The Ketogenic Diet in Dravet Syndrome

(2013) Linda Laux et al.   JOURNAL OF CHILD NEUROLOGY

Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy

(2013) Rima Nabbout et al.   Orphanet Journal of Rare Diseases

Successful use of fenfluramine as an add-on treatment for Dravet syndrome

(2012) Berten Ceulemans et al.   EPILEPSIA

Bromide in Patients with SCN1A-Mutations Manifesting as Dravet Syndrome

(2012) Jan Lotte et al.   NEUROPEDIATRICS

Concentrations of Stiripentol in Children and Adults With Epilepsy

(2012) Theodor W. May et al.   THERAPEUTIC DRUG MONITORING

Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology

(2011) C. B. Catarino et al.   BRAIN

Nonpharmacologic treatments of Dravet syndrome: Focus on the ketogenic diet

(2011) Roberto Horacio Caraballo   EPILEPSIA

Protective effect of the ketogenic diet in Scn1a mutant mice

(2011) Stacey B. B. Dutton et al.   EPILEPSIA

Dravet syndrome: The long-term outcome

(2011) Pierre Genton et al.   EPILEPSIA

Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: A prospective pilot study

(2011) Rima Nabbout et al.   EPILEPSIA

Unusual consequences of status epilepticus in Dravet syndrome

(2010) M. Chipaux et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

A long-term follow-up study of Dravet syndrome up to adulthood

(2009) Mari Akiyama et al.   EPILEPSIA

Stiripentol open study in Japanese patients with Dravet syndrome

(2009) Yushi Inoue et al.   EPILEPSIA

Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study

(2008) Richard FM Chin et al.   LANCET NEUROLOGY

The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator

(2008) Janet L. Fisher   NEUROPHARMACOLOGY

Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

(2008) Sylvain Rheims et al.   PLOS MEDICINE

Severe myoclonic epilepsy in infancy: A systematic review and a meta-analysis of individual patient data

(2007) Behrouz Kassaï et al.   EPILEPSIA