Article
Nutrition & Dietetics
Ahmed Ismaeel, Joseph A. Laudato, Emma Fletcher, Evlampia Papoutsi, Abigail Tice, Lara S. Hwa, Dimitrios Miserlis, Athanasios Z. Jamurtas, Jennifer Steiner, Panagiotis Koutakis
Summary: This study aimed to assess the concurrent effect of chronic heavy alcohol consumption and consumption of a high-fat diet on skeletal muscle oxidative stress and mitochondrial dysfunction. The results showed that a high-fat diet may exacerbate the negative effects of alcohol on skeletal muscle mitochondrial health and oxidative stress.
Review
Biochemistry & Molecular Biology
Burak Mugdat Karan, Karis Little, Josy Augustine, Alan W. Stitt, Tim M. Curtis
Summary: Diabetic retinopathy (DR) is a complication of diabetes mellitus that can cause vision loss and blindness. This review article explores the impact of oxidative stress, lipid-derived aldehydes, and advanced lipoxidation end products (ALEs) on the progression of DR. It also highlights the importance of aldehyde metabolism in the retina, particularly the role of aldehyde dehydrogenase (ALDH) and aldo-keto reductase (AKR) enzymes. The review discusses potential therapeutic strategies, such as gene therapy and pharmacological compounds, that can enhance the expression and activity of ALDH and AKR enzymes to protect the retina and preserve vision in diabetic patients.
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Anja Plemenitas Iljes, Vita Dolzan
Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Tanja Veljovic, Milanko Djuric, Jelena Mirnic, Ivana Gusic, Aleksandra Maletin, Bojana Ramic, Isidora Neskovic, Karolina Vukoje, Snezana Brkic
Summary: This study compared salivary and plasma MDA levels in periodontitis patients with healthy controls and evaluated the effectiveness of periodontal therapy. The results showed higher levels of salivary and plasma MDA in the periodontitis group, and a significant decrease in salivary MDA levels after periodontal therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hun Ho Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Soo Youl Kim, Seok-Gu Kang
Summary: This study demonstrates that combination therapy with the chemotherapeutic drug, gossypol, and phenformin can significantly reduce the stemness and invasiveness of GBM tumorspheres, enhancing therapeutic effects through multiple mechanisms of action.
Editorial Material
Biochemistry & Molecular Biology
Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek
Summary: Nitroxyl (HNO), a one-electron reduced and protonated congener of nitric oxide (NO), has been recently discovered in Arabidopsis thaliana. Due to its distinct chemical properties, further studies are needed to determine the impacts of HNO on physiological processes.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Chemistry, Organic
Min Peng, Quan-Rong Du, Xue Yao, Chun-Ni Li, Yang Tian, Yu Peng, Ya-Wen Wang
Summary: A simple fluorescein derivative was synthesized as a fluorescent probe for detecting malondialdehyde (MDA). The probe achieved ring-opening of fluorescein and formation of a benzohydrazide derivative through a synergistic reaction. It exhibited high sensitivity and selectivity for MDA detection, and could quickly and visually detect MDA within 60 s using UV-vis and fluorescent modes. Moreover, the probe showed excellent performance in imaging MDA in living cells and bacteria.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner
Summary: The transient receptor potential (TRP) cation channel superfamily consists of more than 50 channels playing crucial roles in physiological processes. Aldehydes can activate TRP channels, triggering a cellular cascade that may lead to disease pathophysiology. Studies have shown that aldehyde dehydrogenase 2 protects against aldehyde toxicity by clearing toxic aldehydes.
Article
Cardiac & Cardiovascular Systems
Ligia A. Kiyuna, Darlan S. Candido, Luiz R. G. Bechara, Itamar C. G. Jesus, Lisley S. Ramalho, Barbara Krum, Ruda P. Albuquerque, Juliane C. Campos, Luiz H. M. Bozi, Vanessa O. Zambelli, Ariane N. Alves, Nicolas Campolo, Mauricio Mastrogiovanni, Silvina Bartesaghi, Alejandro Leyva, Rosario Duran, Rafael Radi, Guilherme M. Arantes, Edecio Cunha-Neto, Marcelo A. Mori, Che-Hong Chen, Wenjin Yang, Daria Mochly-Rosen, Ian J. MacRae, Ludmila R. P. Ferreira, Julio C. B. Ferreira
Summary: This study investigates the mechanisms and potential treatment for the deleterious effects of 4-hydroxynonenal (4-HNE) in heart failure. The results show that 4-HNE inhibits Dicer, which impairs miRNA processing. Boosting 4-HNE clearance through pharmacological activation of aldehyde dehydrogenase 2 (ALDH2) restores Dicer activity and miRNA biogenesis, offering a potential treatment for heart failure patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Plant Sciences
Yingxue Cao, Jing Wang, Siqi Zhao, Qingxi Fang, Jingwen Ruan, Shuanglin Li, Tongxin Liu, Yuxin Qi, Ling Zhang, Xiaoming Zhang, Fanli Meng
Summary: The introduction of the ALDH coding gene AhALDH3H1 into the soybean genome increases its tolerance to saline-alkali stress by increasing aldehyde dehydrogenase activity, thus reducing the accumulation of toxic metabolites. The analysis of the transcriptome and metabolome suggests that cell wall structure and metabolite transport are crucial for enhancing the tolerance of transgenic soybean to saline-alkali stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Jessica Maiuolo, Francesca Oppedisano, Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Roberta Macri, Federica Scarano, Annarita Coppoletta, Antonio Cardamone, Francesca Bosco, Rocco Mollace, Carolina Muscoli, Ernesto Palma, Vincenzo Mollace
Summary: Reduced bioavailability of NO is associated with cardiovascular disease, and organic nitrates like GTN are commonly used to treat it. However, chronic use of GTN can lead to nitrate tolerance, requiring higher doses for the same effect. Nitrate tolerance is also accompanied by a decrease in ALDH2 catalytic activity. Introducing natural products containing nitrates into the diet can help reduce GTN intake and nitrate tolerance, while maintaining proper ALDH2 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Gudrun Pahlke, Katarina Ahlberg, Anne Oertel, Theresa Janson-Schaffer, Stephanie Grabher, Hans-Peter Mock, Andrea Matros, Doris Marko
Summary: The study found that cyanidin 3-O-glucoside (Cy-3-glc) and cyanidin 3-O-sambubioside (Cy-3-sam) were the most potent in terms of antioxidant properties and protection against hydrogen peroxide-induced reactive oxygen species levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Article
Environmental Sciences
Camila Fatima Rutkoski, Suelen Cristina Grott, Nicole Grasmuk Israel, Fernando de Campos Guerreiro, Sabrina Santos, Priscila Aparecida Horn, Amanda Alves Trentini, Elizia Barbosa da Silva, Claudia Almeida Coelho de Albuquerque, Thiago Caique Alves, Eduardo Alves de Almeida
Summary: This study evaluated the effects of environmentally realistic concentrations of antibiotics on Lithobates catesbeianus tadpoles. The results showed that these antibiotics significantly disrupted the tadpoles' physiology, potentially affecting their survival rate in natural environments.
Article
Zoology
Priscila L. R. Dourado, Daina Lima, Jaco J. Mattos, Afonso C. D. Bainy, Suelen C. Grott, Thiago C. Alves, Eduardo Alves de Almeida, Danilo G. Humberto da Silva
Summary: This study investigates the effects of the insecticide fipronil on the GABAergic responses of the Nile Tilapia to hypoxia. The results show that hypoxia has opposite effects on the gene transcription of ionotropic and metabotropic GABA receptors, while fipronil impairs the brain GABAergic signaling of hypoxia-tolerant fish during the transition from normoxia to acute hypoxia.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Ecology
David Sanchez-Domene, Fernando R. da Silva, Diogo B. Provete, Alba Navarro-Lozano, Raphael D. Acayaba, Cassiana C. Montagner, Denise de C. Rossa-Feres, German M. Lopez-Iborra, Eduardo A. Almeida
Summary: Global demand for crops will increase in the future, contributing to the expansion of arable land and loss of natural habitats. This study in Brazil examined the impact of agrochemicals and landscape changes on tropical freshwater biodiversity. The findings suggest that certain frog species are negatively affected by high concentrations of agrochemicals in sugarcane-dominated agroecosystems, highlighting the importance of conserving ponds near forests and reducing agrochemical runoffs.
ECOLOGICAL APPLICATIONS
(2023)
Review
Genetics & Heredity
Victoria Simoes Bernardo, Flaviene Felix Torres, Danilo Gruenig Humberto Da Silva
Summary: This review highlights the importance of oxidative stress in human health and disease, focusing on the extensively studied transcription factor FoxO3, which plays a vital role in regulating gene networks involved in cellular metabolism, cell death, and stress resistance. The review also discusses the regulatory mechanisms of FoxO3 expression and activity, such as post-translational modifications and non-coding RNAs. Additionally, the article explores the interaction between FoxO3 and reactive oxygen species, suggesting potential pathogenic mechanisms for various diseases and the utility of FoxO3-regulated signaling pathways as therapeutic targets and diagnostic biomarkers.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Editorial Material
Environmental Sciences
Eduardo Alves de Almeida, Afonso Celso Dias Bainy, Lucia Guilhermino
Article
Environmental Sciences
Suelen Cristina Grott, Nicole Grasmuk Israel, Daina Lima, Camila Lisarb Velasquez Bastolla, Francisco Carneiro, Thiago Caique Alves, Daiane Bitschinski, Afonso Celso Dias Bainy, Elizia Barbosa da Silva, Claudia Almeida Coelho de Albuquerque, Eduardo Alves de Almeida
Summary: This study evaluated the influence of different temperatures and exposure to the herbicide ametryn on the thyroidogenesis of bullfrog tadpoles. Results showed that higher temperature and ametryn exposure caused a delay in tadpole development and decreased the area and number of follicles in the thyroid gland. Transcript levels of thyroid hormone receptors and iodothyronine deiodinase 3 were lower at higher temperatures, indicating a developmental delay. Tadpoles exposed to high levels of ametryn also exhibited delayed development and lower transcript levels, possibly related to lower levels of estradiol.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Priscila Aparecida Horn, Ana Lucia Bertarello Zeni, Natalia Cavichioli, Evelyn Winter, Keila Zaniboni Siqueira Batista, Luciano Vitali, Eduardo Alves de Almeida
Summary: This study characterized the chemical composition of brewer's spent yeast (BSY) from two different beer productions and tested its cytotoxicity in various cell lineages. The results showed that BSY samples had similar lipid and ash content but slight differences in other nutritional components. BSY2 sample had higher concentrations of glucans and phenolic compounds. Both BSY1 and BSY2 extracts demonstrated similar antioxidant capacity and were not cytotoxic to most cell lines except PANC-1 cells. These findings suggest that brewery residue can be a value-added functional food with potential adjuvant role against PANC-1 cell lines.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Camila L. V. Bastolla, Daina Lima, Jaco J. Mattos, Vera H. V. Dias, Barbara P. H. Righetti, Carlos H. A. M. Gomes, Herculano Cella, Isis M. M. Reis, Miguel Saldana-Serrario, Clarissa P. Ferreira, Marcia C. Bicego, Satie Taniguchi, Flavia L. Zacchi, Afonso C. D. Bainy
Summary: This study aimed to investigate the differences in antioxidant and biotransformation systems of Crassostrea gigas, C. gasar, and C. rhizophorae and their effects resulting from CHR exposure. CHR bioaccumulated in tissues and different remaining levels of CHR in water after 96 hours were observed in aquaria containing C. gigas or C. gasar oysters, possibly due to different filtration rates between these species. Differential antioxidant enzyme activities were observed in gills and digestive glands of oysters exposed to CHR, suggesting that C. gigas and C. gasar are more responsive to CHR.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clarissa P. Ferreira, Camila L. V. Bastolla, Miguel Saldana-Serrano, Daina Lima, Carlos H. A. de M. Gomes, Declan C. Schroeder, Afonso C. D. Bainy, Karim H. Luchmann
Summary: Metal contamination affects aquatic species, and mollusk bivalves are suitable for monitoring coastal pollution. Metal exposure can disrupt homeostasis and harm cellular processes, but organisms have evolved mechanisms to counteract metal toxicity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Lilian Nogueira, Danielly Garcia, Fernando Sanzi Cortez, Camilo Dias Seabra Pereira, Eduardo Alves de Almeida
Summary: This study assessed the combined effect of hypoxia and diesel exposure on biochemical parameters of Perna perna mussels. The results showed that cycles of air exposure and reoxygenation caused oxidative stress and antioxidant modulation in both the gills and digestive glands. The presence of diesel in water apparently enhanced the mussels' capacity to avoid lipid peroxidation under hypoxia and reoxygenation stress.
MARINE POLLUTION BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Gabriel S. Cruz, Juliana R. Moser, Miguel Saldana-Serrano, Camila L. V. Bastolla, Daina Lima, Carlos H. A. M. Gomes, Micheli R. de Castro, Ucledia R. A. dos Santos, Gabriel S. Coutinho, Jaco J. Mattos, Maria R. F. Marques
Summary: This study investigated the effects of benzophenone-3 (BP-3) on the antioxidant status of Perna perna mussels exposed to concentrations of 0.1 and 3 μg/L for 72 hours and 7 days. The results showed that the activity of G6PDH and GPx significantly decreased after exposure for 7 days to 0.1 μg/L. However, there were no significant differences observed in GST activity and MDA levels, regardless of the exposure time.
Article
Environmental Sciences
Tays Daiane Izidoro, Suelen Cristina Grott, Bruno Busnello Kubiak, Thales Renato Ochotorena de Freitas, Thiago Caique Alves, Eduardo Alves Almeida, Daniel Galiano
Summary: Rampant urbanization in coastal areas impacts the health of the tuco-tuco Ctenomys flamarioni. This study found that individuals in the impacted area had higher levels of oxidative damage and lower antioxidant activity, indicating the negative effect of anthropogenic activities on the oxidative status of animals in this environment. The findings can be used as a reference for future studies on tuco-tucos.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)