Nanoparticle Delivery Systems for DNA/RNA and their Potential Applications in Nanomedicine

Safety and effectiveness of sodium colistimethate-loaded nanostructured lipid carriers (SCM-NLC) against P. aeruginosa: in vitro and in vivo studies following pulmonary and intramuscular administration

(2019) M. Pastor et al.   Nanomedicine-Nanotechnology Biology and Medicine

RGD/TAT-functionalized chitosan- graft -PEI-PEG gene nanovector for sustained delivery of NT-3 for potential application in neural regeneration

(2018) Dongni Wu et al.   Acta Biomaterialia

Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer

(2018) Xueling Guo et al.   CARBOHYDRATE POLYMERS

New cyclodextrin-based nanocarriers for drug delivery and phototherapy using an irinotecan metabolite

(2018) Elham Einafshar et al.   CARBOHYDRATE POLYMERS

Cytotoxic consequences of Halloysite nanotube/iron oxide nanocomposite and iron oxide nanoparticles upon interaction with bacterial, non-cancerous and cancerous cells

(2018) R. Abhinayaa et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Feed pellets containing chitosan nanoparticles as plasmid DNA oral delivery system for fish: In vivo assessment in gilthead sea bream ( Sparus aurata ) juveniles

(2018) M.I. Sáez et al.   FISH & SHELLFISH IMMUNOLOGY

Encapsulation of micronutrients resveratrol, genistein, and curcumin by folic acid-PAMAM nanoparticles

(2018) P. Chanphai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases

(2018) Natalie Pursell et al.   MOLECULAR THERAPY

Ultrasound-guided delivery of thymidine kinase–nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy

(2018) Rammohan Devulapally et al.   Nanomedicine

Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer

(2018) Alevtina S. Semkina et al.   Nanomedicine-Nanotechnology Biology and Medicine

Applications of gold nanoparticles in virus detection

(2018) Mohamed Shehata Draz et al.   Theranostics

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

(2018) Wing Yin Tong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo

(2018) Ying Ji et al.   BIOMATERIALS

Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

(2017) Chen Shen et al.   International Journal of Nanomedicine

Prospects of Gene Therapy for Pulmonary Diseases: Progress and Limitations

(2017) Garyfalia Karponi et al.   Medicinal Chemistry

Nano-based delivery of RNAi in cancer therapy

(2017) Yong Xin et al.   Molecular Cancer

β-Lactoglobulin: An efficient nanocarrier for advanced delivery systems

(2017) Zahra Shafaei et al.   Nanomedicine-Nanotechnology Biology and Medicine

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

(2017) Jayesh A. Kulkarni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Poly- L -lysine brushes on magnetic nanoparticles for ultrasensitive detection of Escherichia coli O157: H7

(2017) Jing Wu et al.   TALANTA

Plasmonic silver nanoshells for drug and metabolite detection

(2017) Lin Huang et al.   Nature Communications

Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

(2017) Yongbo Yang et al.   Theranostics

RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA

(2017) Sebastian Aguiar et al.   Translational Neurodegeneration

Biologically Inspired Polydopamine Capped Gold Nanorods for Drug Delivery and Light-Mediated Cancer Therapy

(2016) Shaowei Wang et al.   ACS Applied Materials & Interfaces

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

(2016) Yang Liu et al.   BIOMATERIALS

Phase I Study of PSMA-Targeted Docetaxel-Containing Nanoparticle BIND-014 in Patients with Advanced Solid Tumors

(2016) D. D. Von Hoff et al.   CLINICAL CANCER RESEARCH

Nanotoxicology

(2016) David W. Hobson   INTERNATIONAL JOURNAL OF TOXICOLOGY

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study

(2016) Kathleen F Pirollo et al.   MOLECULAR THERAPY

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4 + colorectal cancer models

(2016) María Virtudes Céspedes et al.   Nanomedicine-Nanotechnology Biology and Medicine

Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

(2016) Ying-Zheng Zhao et al.   PLoS One

Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma

(2016) Hui-Ying Xue et al.   Oncotarget

Recent progress in nanomaterials for gene delivery applications

(2016) Erhan Keles et al.   Biomaterials Science

Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease

(2016) Kai Zhu et al.   Stem Cells International

Facile Synthesis of Large-Pore Bicontinuous Cubic Mesoporous Silica Nanoparticles for Intracellular Gene Delivery

(2016) Anand Kumar Meka et al.   ChemNanoMat

pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response

(2015) Qi Liu et al.   ACS Nano

Delivery of anti-microRNA-21 antisense-oligodeoxynucleotide using amphiphilic peptides for glioblastoma gene therapy

(2015) Hojung Song et al.   JOURNAL OF DRUG TARGETING

Simultaneous Drug and Gene Delivery from the Biodegradable Poly(-caprolactone) Nanofibers for the Treatment of Liver Cancer

(2015) Hui-Lian Che et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Induced adverse effects of prenatal exposure to silver nanoparticles on neurobehavioral development of offspring of mice

(2015) Shahab Ghaderi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Smart Polymeric Nanoparticles for Cancer Gene Delivery

(2015) Guimei Lin et al.   MOLECULAR PHARMACEUTICS

Lipid nanoparticles for the topical delivery of retinoids and derivatives

(2015) Javier O Morales et al.   Nanomedicine

Encapsulation of hydrophobic allergens into nanoparticles improves the in vitro immunological diagnosis of allergic contact dermatitis

(2015) Angèle Cortial et al.   Nanomedicine-Nanotechnology Biology and Medicine

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

(2015) Fleur M. van der Valk et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems

(2015) Maria Manuela Gaspar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment

(2015) João Conde et al.   NATURE MATERIALS

Combined Delivery of Temozolomide and Anti-miR221 PNA Using Mesoporous Silica Nanoparticles Induces Apoptosis in Resistant Glioma Cells

(2015) Alessandro Bertucci et al.   Small

Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells

(2015) B. Santos-Carballal et al.   Scientific Reports

Magnetic Nanoparticles in Cancer Theranostics

(2015) Oliviero L. Gobbo et al.   Theranostics

Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

(2015) Hagit Sela et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

(2014) Shuaidong Huo et al.   ACS Nano

Zinc oxide nanoparticles based microfluidic immunosensor applied in congenital hypothyroidism screening

(2014) Marco A. Seia et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer

(2014) Xiongwei Deng et al.   BIOMATERIALS

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

(2014) Henrique Lemos et al.   Expert Review of Clinical Immunology

Summary of bi-shRNAfurin/GM-CSF Augmented Autologous Tumor Cell Immunotherapy (FANG™) in Advanced Cancer of the Liver

(2014) John Nemunaitis et al.   ONCOLOGY

RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice

(2014) M. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Magnetic Nanoparticle-based MicroRNA and Hyperthermia Therapy to Enhance Apoptosis in Brain Cancer Cells

(2014) Perry T. Yin et al.   Small

Nanoparticle-Mediated Systemic Delivery of siRNA for Treatment of Cancers and Viral Infections

(2014) Mohamed Shehata Draz et al.   Theranostics

Degradable Hyaluronic Acid/Protamine Sulfate Interpolyelectrolyte Complexes as miRNA-Delivery Nanocapsules for Triple-Negative Breast Cancer Therapy

(2014) Shihua Wang et al.   Advanced Healthcare Materials

Gene Therapy Using Stem Cells

(2014) E. R. Burnight et al.   Cold Spring Harbor Perspectives in Medicine

Silver Nanoscale Antisense Drug Delivery System for Photoactivated Gene Silencing

(2013) Paige K. Brown et al.   ACS Nano

When carbon nanotubes encounter the immune system: Desirable and undesirable effects

(2013) Hélène Dumortier   ADVANCED DRUG DELIVERY REVIEWS

The targeted co-delivery of DNA and doxorubicin to tumor cells via multifunctional PEI-PEG based nanoparticles

(2013) Chunxi Liu et al.   BIOMATERIALS

Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model

(2013) Junchao Duan et al.   BIOMATERIALS

Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition

(2013) Solenne Bire et al.   BMC BIOTECHNOLOGY

Integrated Hollow Mesoporous Silica Nanoparticles for Target Drug/siRNA Co-Delivery

(2013) Xing Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

Multimodality Imaging of RNA Interference

(2013) T. Nayak et al.   CURRENT MEDICINAL CHEMISTRY

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations

(2013) Xinmei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Chitosan-based siRNA delivery systems

(2013) Héloïse Ragelle et al.   JOURNAL OF CONTROLLED RELEASE

Protection Against Lethal Marburg Virus Infection Mediated by Lipid Encapsulated Small Interfering RNA

(2013) Raul Ursic-Bedoya et al.   JOURNAL OF INFECTIOUS DISEASES

Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors

(2013) Neil Senzer et al.   MOLECULAR THERAPY

TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

(2013) So Jin Lee et al.   MOLECULAR THERAPY

In Vitro and In Vivo Efficacy of SYL040012, a Novel siRNA Compound for Treatment of Glaucoma

(2013) Tamara Martínez et al.   MOLECULAR THERAPY

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

(2013) Rongqin Huang et al.   PHARMACEUTICAL RESEARCH

Pluripotent stem cells and gene therapy

(2013) Pavel Simara et al.   Translational Research

Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing

(2012) João Conde et al.   ACS Nano

Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach

(2012) Ali Yilmaz et al.   EUROPEAN HEART JOURNAL

Polymer Nanoparticle-Mediated Delivery of MicroRNA Inhibition and Alternative Splicing

(2012) Christopher J. Cheng et al.   MOLECULAR PHARMACEUTICS

Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy

(2012) Yuling Xiao et al.   Nanoscale

Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans

(2012) Charles Lu et al.   PLoS One

The Business of RNAi Therapeutics in 2012

(2012) Dirk Haussecker   Molecular Therapy-Nucleic Acids

Facile Synthesis of Monodispersed Mesoporous Silica Nanoparticles with Ultralarge Pores and Their Application in Gene Delivery

(2011) Mi-Hee Kim et al.   ACS Nano

Toxicology of Nanomaterials Used in Nanomedicine

(2011) Jinshun Zhao et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

Gold nanoparticles: preparation, properties, and applications in bionanotechnology

(2011) Yi-Cheun Yeh et al.   Nanoscale

Effective Stabilization and Delivery of siRNA: Reversible siRNA−Phospholipid Conjugate in Nanosized Mixed Polymeric Micelles

(2010) Tiziana Musacchio et al.   BIOCONJUGATE CHEMISTRY

Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles

(2010) Yunyi Wong et al.   BIOMATERIALS

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine

(2010) S. K. Libutti et al.   CLINICAL CANCER RESEARCH

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

(2010) Weikang Tao et al.   MOLECULAR THERAPY

Magnetic nanoparticles in biomedicine: synthesis, functionalization and applications

(2010) Reynolds A Frimpong et al.   Nanomedicine

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases

(2010) Biana Godin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ultrasensitive and Highly Selective Detection of Alzheimer’s Disease Biomarker Using Two-Photon Rayleigh Scattering Properties of Gold Nanoparticle

(2009) Adria Neely et al.   ACS Nano

Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: Observations from the PROTECT-TIMI 30 Trial

(2009) Sean R. Wilson et al.   AMERICAN HEART JOURNAL

Controlling HBV Replicationin Vivoby Intravenous Administration of Triggered PEGylated siRNA-Nanoparticles

(2009) Sergio Carmona et al.   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

(2008) Hanna L. Karlsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nonviral gene transfection nanoparticles: function and applications in the brain

(2008) Indrajit Roy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Novel cationic solid lipid nanoparticles enhanced p53 gene transfer to lung cancer cells

(2007) S CHOI   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes

(2007) Ximing Xu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] for biomedical applications

(2007) Jyotsnendu Giri et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

Composite Nano-Titanium Oxide–Chitosan Artificial Skin Exhibits Strong Wound-Healing Effect—An Approach with Anti-Inflammatory and Bactericidal Kinetics

(2007) Chiung-Chi Peng et al.   MACROMOLECULAR BIOSCIENCE