Neurological Disorder Drug Discovery from Gene Expression with Tensor Decomposition

Drug candidate identification based on gene expression of treated cells using tensor decomposition-based unsupervised feature extraction for large-scale data

(2019) Y-h. Taguchi   BMC BIOINFORMATICS

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

(2019) Dongsheng Yuan et al.   Cell Communication and Signaling

The Kipoi repository accelerates community exchange and reuse of predictive models for genomics

(2019) Žiga Avsec et al.   NATURE BIOTECHNOLOGY

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Tensor decomposition-based and principal-component-analysis-based unsupervised feature extraction applied to the gene expression and methylation profiles in the brains of social insects with multiple castes

(2018) Y.-H. Taguchi   BMC BIOINFORMATICS

Decoding Common Features of Neurodegenerative Disorders: From Differentially Expressed Genes to Pathways

(2018) Rabia Habib et al.   CURRENT GENOMICS

Tensor Decomposition-Based Unsupervised Feature Extraction Can Identify the Universal Nature of Sequence-Nonspecific Off-Target Regulation of mRNA Mediated by MicroRNA Transfection

(2018) Y.-H. Taguchi   Cells

A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer's Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls

(2018) Sébastien S. Hébert et al.   JOURNAL OF ALZHEIMERS DISEASE

All (animal) models (of neurodegeneration) are wrong. Are they also useful?

(2018) Richard M. Ransohoff   JOURNAL OF EXPERIMENTAL MEDICINE

SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation

(2017) Vijay Badrinarayanan et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes

(2017) Valentin K. Gribkoff et al.   NEUROPHARMACOLOGY

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects

(2017) Siranjeevi Nagaraj et al.   Oncotarget

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions

(2017) Cemil Kerimoglu et al.   Cell Reports

miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline

(2017) Asha Rani et al.   Frontiers in Aging Neuroscience

Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease

(2017) Lin-lin Wang et al.   Biomed Research International

Tensor decomposition-based unsupervised feature extraction applied to matrix products for multi-view data processing

(2017) Y-h. Taguchi   PLoS One

Identification of candidate drugs using tensor-decomposition-based unsupervised feature extraction in integrated analysis of gene expression between diseases and DrugMatrix datasets

(2017) Y.-h. Taguchi   Scientific Reports

Tensor decomposition for multiple-tissue gene expression experiments

(2016) Victoria Hore et al.   NATURE GENETICS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß 1-42 oligomers in mice

(2016) Gian Marco Leggio et al.   PHARMACOLOGICAL RESEARCH

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

(2014) Kasandra Burgos et al.   PLoS One

Understanding data fusion within the framework of coupled matrix and tensor factorizations

(2013) Evrim Acar et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Tensor Decompositions and Applications

(2009) Tamara G. Kolda et al.   SIAM REVIEW