Article
Peripheral Vascular Disease
Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study found that female patients with bilateral primary aldosteronism have worse renal outcomes compared to male patients after receiving mineralocorticoid receptor antagonist treatment. Despite similar systolic blood pressure levels between the sexes, women experienced a greater decline in estimated glomerular filtration rate, especially during the late phase of 6 to 60 months post-treatment initiation.
Review
Behavioral Sciences
Claire L. Pince, Kimberly E. Whiting, Tammy Wang, Andras H. Leko, Lisa A. Farinelli, Diane Cooper, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio
Summary: This scoping review summarizes the role of aldosterone and mineralocorticoid receptor (MR) in addiction and the potential effects of pharmacological manipulations of MR on addiction-related outcomes. The findings suggest that dysregulations of aldosterone and MR occur in both peripheral and central systems and are influenced by drug exposure patterns and genetic factors. Antagonism of MR holds promise as a potential target for the treatment of addiction, but further research is needed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Geriatrics & Gerontology
Cui-Juan Zhang, Hui Li, Yun-Zhao Xiong, Yi Chang, Fan Yang, Xue-Lian Ma, Xiang-Ting Wang, Tatsuo Shimosawa, En-Sheng Ji, Qing-You Xu
Summary: Obstructive sleep apnea syndrome (OSAS) is a common sleep breathing disorder that is associated with chronic kidney disease. This study found that under hypoxic conditions, macrophages can transform into myofibroblasts, leading to renal fibrosis, and the activation of mineralocorticoid receptor may be involved in this transformation. Blocking mineralocorticoid receptor can attenuate renal injury.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eun Jung Park, Jihyun Je, Theodomir Dusabimana, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Renal ischemia reperfusion (IR) injury can lead to multiple organ failure, including the liver and intestine. The activation of mineralocorticoid receptor (MR) is involved in this process. This study demonstrated that the MR antagonist canrenoic acid (CA) protects against AKI-induced hepatic and intestinal injury through reducing oxidative stress, inflammatory response, and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Peter Kolkhof, Amer Joseph, Ulrich Kintscher
Summary: Over the past 30 years, there has been significant progress in understanding the role of aldosterone and mineralocorticoid receptor in cardiovascular and kidney diseases. Ongoing research is focused on developing safer and more effective nonsteroidal MR antagonists.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Zachary M. Howard, Chetan K. Gomatam, Arden B. Piepho, Jill A. Rafael-Fortney
Summary: Duchenne muscular dystrophy (DMD) is a muscle degenerative disease caused by the loss of dystrophin protein. Current standard-of-care treatment for DMD has limited efficacy and serious side effects. Mineralocorticoid receptor antagonists (MRAs) have shown promise as a therapeutic target for DMD, as they can improve muscle function and reduce inflammation and fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Nobuhiro Ayuzawa, Toshiro Fujita
Summary: Hypertension and its comorbidities are major public health concerns related to modern lifestyle factors. Aldosterone and its receptor, MR, play crucial roles in salt-sensitive hypertension and renal injuries. Obesity-related overproduction of aldosterone and ligand-independent signaling are identified as novel mechanisms of MR activation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Peripheral Vascular Disease
Candee T. Barris, Jessica L. Faulkner, Eric J. Belin de Chantemele
Summary: Several clinical and large population studies have found that women are more salt-sensitive than men, and this sex difference is influenced by female sex chromosomes and hormones. Women of all ethnicities, both premenopausal and postmenopausal, are more salt-sensitive. Menopause exacerbates the severity and prevalence of salt-sensitive blood pressure (SSBP), indicating the role of sex hormones. Activation of aldosterone-ECMR axis and ENaC in females contribute to vascular dysfunction and SSBP. The increased prevalence and susceptibility of SSBP in women are influenced by sex hormones and sex chromosome complement.
Review
Endocrinology & Metabolism
Gianluigi Savarese, Felix Lindberg, Gerasimos Filippatos, Javed Butler, Stefan D. Anker
Summary: The overactivation of mineralocorticoid receptors affects multiple physiological systems, and the use of classical MR antagonists has shown improvements in heart failure. However, concerns about side effects and limited tolerability have hindered their implementation in other settings. Non-steroidal MR antagonists have shown potential benefits and better safety profiles. This review provides an overview of the impact of MR overactivation and discusses the potential of non-steroidal MR antagonists.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor (MR) antagonists, also known as aldosterone blockers, have shown clinical benefits in treating patients with heart failure, including those with reduced ejection fraction and preserved ejection fraction with reduced left ventricular filling. The MR has various physiological and pathophysiological roles in the heart, vasculature, and other tissues, which underpin the use of MR antagonists in cardiovascular disease, particularly heart failure. The development of MR antagonists has progressed from potassium-sparing diuretics to more receptor-selective options, demonstrating the evolution of treatment options for cardiovascular diseases.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor antagonists, also known as aldosterone blockers, have been widely recognized for their clinical benefits in treating heart failure, improving outcomes for both HFrEF and HFpEF patients. As research continues to evolve, new nonsteroidal receptor antagonists like esaxerenone and finerenone have emerged, showcasing the constantly evolving landscape of cardiovascular disease treatment.
Article
Peripheral Vascular Disease
Daigoro Hirohama, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Wakako Kawarazaki, Wataru Fujii, Shigeyoshi Oba, Shigeru Shibata, Takeshi Marumo, Toshiro Fujita
Summary: The study revealed that the activation of the Rac1-MR pathway contributes to the progression of DKD by causing hypertension and podocyte injury, highlighting MR antagonism and Rac1 inhibition as a novel strategy for DKD treatment.
Article
Endocrinology & Metabolism
Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sanchez-Lopez, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Summary: Add-on treatment with corticosterone can partially attenuate the metabolic effects of synthetic glucocorticoid dexamethasone, while exacerbating other effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaomeng Gao, Jingyue Chang, Yi Chang, Lili Fan, Ziqian Liu, Cuijuan Zhang, Tatsuo Shimosawa, Fan Yang, Qingyou Xu
Summary: Renal fibrosis, a common process in chronic kidney disease (CKD), is influenced by angiogenesis. Vascular endothelial cells contribute to renal fibrosis through phenotypic transformation and extracellular matrix secretion. Aldosterone, an inflammatory mediator, stimulates angiogenesis via mineralocorticoid receptor (MR) activation. Clinical evidence suggests that MR blockers (MRBs) protect damaged kidneys possibly by inhibiting angiogenesis. In this study, aldosterone infusion in mice induced angiogenesis and endothelial-mesenchymal transition (EndMT), highlighting their involvement in renal fibrosis. Aldosterone induced inflammation and macrophages secreted vascular endothelial growth factor (VEGF)-A to regulate angiogenesis through MR activation, while EndMT occurred in response to transforming growth factor (TGF)-β1 induction, contributing to renal fibrosis. These effects were counteracted by the MRB esaxerenone. These findings suggest that reducing angiogenesis may be an effective strategy for treating renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Michael Crompton, Laura J. Skinner, Simon C. Satchell, Matthew J. Butler
Summary: The renin angiotensin aldosterone system plays a crucial role in blood pressure regulation. Excessive stimulation of mineralocorticoid receptors by aldosterone can lead to various pathological effects in the heart, kidney, and endothelial cells. In this article, we discussed the association between hyperaldosteronism and fibrosis, cardiac dysfunction, maladaptive hypertrophy, proteinuria, and fibrosis. We also reviewed how aldosterone exposure damages the endothelial glycocalyx and suggested that preventing glycocalyx remodeling may offer a novel strategy for limiting endothelial damage.
Editorial Material
Gastroenterology & Hepatology
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Ken Ishimura, Kunihisa Uchita, Akira Nishiyama, Tsutomu Masaki
Article
Surgery
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tadayuki Takata, Kazuhiro Kozuka, Takanori Matsui, Nobuya Kobayashi, Taiga Chiyo, Koji Fujita, Joji Tani, Tatsuo Yachida, Akihito Tsuji, Keiichi Okano, Yasuyuki Suzuki, Daisuke Nakano, Akira Nishiyama, Tsutomu Masaki
Summary: This study concludes that the guidewire-assisted OTSC delivery (GOD) method is a feasible and safe technique for delivering OTSC to the small and proximal large intestine.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Kazuhiro Kozuka, Naoya Tada, Takanori Matsui, Taiga Chiyo, Tadayuki Takata, Koji Fujita, Joji Tani, Tatsuo Yachida, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: The study demonstrated that the WaRP method has a high technical success rate and safety in reducing post-ESD bleeding after gastric ESD, making it a simple and reliable approach.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Yasuhiro Goda, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Tingting Shi, Koji Fujita, Joji Tani, Tatsuo Yachida, Masashi Takata, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: This study examined the clinical outcomes and long-term characteristics of patients treated with Over-The-Scope Clip (OTSC). The results showed a 100% clinical success rate and a 2.9% complication rate during the observation period. OTSC remains effective in the long-term.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Biotechnology & Applied Microbiology
Yu Guan, Daisuke Nakano, Lei Li, Haofeng Zheng, Akira Nishiyama, Ye Tian, Lei Zhang
Summary: The study suggests the association between PAR-1 and renal IR injury. Inhibition of PAR-1 with Q94 can alleviate renal IR-induced damage, possibly by improving renal microcirculation and tubular cell survival/proliferation.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Asahiro Morishita, Kei Nomura, Joji Tani, Koji Fujita, Hisakazu Iwama, Kei Takuma, Mai Nakahara, Tomoko Tadokoro, Kyoko Oura, Taiga Chiyo, Shintaro Fujihara, Toshiro Niki, Mitsuomi Hirashima, Akira Nishiyama, Takashi Himoto, Tsutomu Masaki
Summary: Gal-9 suppresses cell proliferation in human colon cancer by inducing apoptosis, impacting cell cycle-related molecules and microRNAs. These findings suggest that Gal-9 could be a potential therapeutic target for colon cancer treatment.
Article
Pharmacology & Pharmacy
Anqi Zhang, Daisuke Nakano, Norihiko Morisawa, Kento Kitada, Wararat Kittikulsuth, Asadur Rahman, Takashi Morikawa, Yoshio Konishi, Akira Nishiyama
Summary: This study investigated the effect of a HIF-PHD inhibitor, molidustat, on salt distribution and excretion in rats with subtotal nephrectomy-induced chronic kidney disease. The results showed that molidustat did not significantly improve blood cell volume or blood pressure, nor did it affect the distribution of sodium, potassium, and water in various samples or urinary sodium excretion in response to acute oral salt loading.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Hematology
Eri Muso, Soichi Sakai, Youske Ogura, Susumu Yukawa, Yoshiki Nishizawa, Noriaki Yorioka, Takao Saito, Masatoshi Mune, Satoshi Sugiyama, Yasuhiko Iino, Tsutomu Hirano, Motoshi Hattori, Tsuyoshi Watanabe, Hitoshi Yokoyama, Hiroshi Sato, Shunya Uchida, Takashi Wada, Tetsuo Shoji, Hiroaki Oda, Kiyoshi Mori, Hideki Kimura, Osamu Ito, Akira Nishiyama, Shoichi Maruyama, Reiko Inagi, Shoichi Fujimoto, Tatsuo Tsukamoto, Yusuke Suzuki, Hirokazu Honda, Tetsuya Babazono, Kazuhiko Tsuruya, Yukio Yuzawa
Summary: Many reports have demonstrated the therapeutic efficacy of LDL-Apheresis in improving heavy proteinuria and severely impaired renal function in cases of drug-resistant nephrotic syndrome. A post hoc analysis of the POLARIS study showed significant improvements in proteinuria and renal function in cases with normal and moderately impaired renal function, and a trend for improvement in severely impaired renal function. Most cases did not progress to end-stage renal disease within 2 years after LDL-A treatment.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Health Care Sciences & Services
Tadashi Sofue, Taiga Hara, Yoko Nishijima, Satoshi Nishioka, Hiroyuki Watatani, Masahito Yamanaka, Norihiro Takahashi, Akira Nishiyama, Tetsuo Minamino
Summary: After the implementation of the NHI special health checkup and chronic kidney disease (CKD) initiative in Kagawa prefecture, there was an increase in the prevalence of CKD and the coverage rate of NHI health checkups.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mai Hattori, Asadur Rahman, Satoshi Kidoguchi, Nourin Jahan, Yoshihide Fujisawa, Norihiko Morisawa, Hiroyuki Ohsaki, Hideki Kobara, Tsutomu Masaki, Akram Hossain, Akumwami Steeve, Akira Nishiyama
Summary: This study investigated the effects of the nonsteroidal mineralocorticoid receptor blocker esaxerenone on blood pressure and renal health in salt-loaded conditions. The results showed that esaxerenone significantly reduced blood pressure and attenuated renal damage induced by high salt intake. These effects were associated with the modulation of sodium homeostasis by esaxerenone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Godoy-Lugo, Max A. Thorwald, Dora A. Mendez, Ruben Rodriguez, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz
Summary: This study found that long-term AT1 blockade can increase nuclear Nrf2 content and reduce the expression of antioxidant enzymes, thereby promoting the development of NAFLD. The angiotensin receptor blocker can alleviate the impact of hyperglycemia on Nrf2, suggesting its role in antioxidant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Asadur Rahman, Nourin Jahan, Md Tanvir Rahman, Akira Nishiyama
Summary: Inappropriate mineralocorticoid receptor (MR) activation in cardiovascular cells has negative effects on cardiac remodeling and function. MR inhibition is an important strategy to overcome cardiovascular dysfunction, but the clinical application of steroidal MR antagonists is limited due to adverse effects. Newer non-steroidal MR antagonists show promise for clinical use, particularly in patients with type 2 diabetes and chronic kidney disease. Pre-clinical and clinical evidence supports the use of non-steroidal MR antagonists in treating cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rudy M. Ortiz, Ryousuke Satou, Jia L. Zhuo, Akira Nishiyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ayako Fujimori, Noriko Nishiyama, Hideki Kobara, Kazuhiro Koduka, Naoya Tada, Takanori Matsui, Taiga Chiyo, Nobuya Kobayashi, Shintaro Fujihara, Tatsuo Yachida, Keiichi Okano, Yasuyuki Suzuki, Daisuke Nakano, Akira Nishiyama, Tsutomu Masaki
Summary: Our study compared the safety and efficacy of pocket creation and ring-thread traction (PRM) with conventional colorectal ESD in non-experts. The results showed that PRM group had significantly shorter procedural time and less additional device usage compared to the C-group.
Article
Chemistry, Analytical
Kosuke Nogo, Kou Ikejima, Wei Qi, Natsumi Kawashima, Tomoya Kitazaki, Satoru Adachi, Kenji Wada, Akira Nishiyama, Ichiro Ishimaru
Summary: This study developed a palm-sized LWIR hyperspectral camera for imaging-type two-dimensional Fourier spectroscopy, which could record the absorbance of black microplastics more quickly and effectively than traditional FPA-FT-IR systems, making it easier to use in the field or on a research vessel.
ANALYTICAL METHODS
(2021)