Article
Psychology, Multidisciplinary
Yu-Kai Chang, Costas Karageorghis, Chun-Chin Wang, Ruei-Hong Li, Feng-Tzu Chen, Ren-Yu Fang, Tsung-Min Hung
Summary: Emerging evidence suggests that acute exercise can improve executive function, particularly in individuals at risk of Alzheimer's disease. This study found that different exercise intensities and durations had similar effects on executive function. These findings contribute to our understanding of the importance of exercise for individuals at risk of Alzheimer's disease.
CURRENT PSYCHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David Dorian, Fernando L. Scolari, Manhal Habib, Darshan H. Brahmbhatt, Cindy Chow, Beata Bruchal-Garbicz, Sara Hoss, Filio Billia, Raymond Chan, Harry Rakowski, Arnon Adler
Summary: There is no association between exercise intensity or duration and phenotypic expression in genotype-positive HCM patients, which is important for physician-patient discussions and supports the recent trend towards more permissive exercise restrictions in HCM.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Clinical Neurology
Stephen Shannon, Mark Shevlin, Noel Brick, Gavin Breslin
Summary: This study examined the associations between frequency, intensity, and duration of muscle-strengthening activities and anxiety, depression, and mental well-being. The results showed that engaging in muscle-strengthening activities for three or more days was associated with fewer symptoms of anxiety and depression. Higher intensity of activities was also associated with lower levels of anxiety and depression. However, adherence to the muscle-strengthening guidelines and the duration of activities did not significantly predict mental health outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Sport Sciences
Andrew M. Alexander, Logan M. Hurla, Kaylin D. Didier, Shane M. Hammer, Korynne S. Rollins, Thomas J. Barstow
Summary: Extreme-intensity exercise leads to greater reduction in neuromuscular function in males compared to females, indicated by lower maximal voluntary contraction and potentiated twitch force. However, there were no sex differences in the magnitude of extreme-intensity exercise.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
D. Maryama Awang Daud, Fatimah Ahmedy, Dayang Marshitah Pg Baharuddin, Zainul Amiruddin Zakaria
Summary: This study compared the effects of intensity and duration on oxidative stress and antioxidant enzyme activity in sedentary adults. The results showed that cycling exercise increased oxidative stress and antioxidant activities, but the effects varied with different intensities and durations.
APPLIED SCIENCES-BASEL
(2022)
Article
Physiology
Samuel T. Howe, Robert J. Aughey, William G. Hopkins, Andrew M. Stewart
Summary: This study investigates the prediction of the relationship between exercise intensity and time in rugby matches using power law models. The results show that peak intensities of professional rugby union matches can be accurately predicted, regardless of playing position, match half, level of competition, or measure of exercise intensity. However, there may be substantial prediction errors at the individual player level.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2022)
Article
Oncology
Arielle S. Gillman, Timothy Helmuth, Claire E. Koljack, Kent E. Hutchison, Wendy M. Kohrt, Angela D. Bryan
Summary: In this study, it was observed that the total amount of exercise completed was not correlated with changes in DNA methylation, but increases in VO(2)max and higher levels of exercise during a follow-up period were associated with changes in methylation of specific genes related to breast cancer. This suggests that increased exercise behavior or fitness may have an impact on gene methylation that is linked to reducing breast cancer risk.
Article
Nutrition & Dietetics
Madison M. Fullerton, Louis Passfield, Martin J. MacInnis, Danilo Iannetta, Juan M. Murias
Summary: Performing constant-load exercise prior to a task significantly impacts subsequent time-to-task failure, with intensity and duration of prior exercise affecting the outcome. Novel findings show that exercising at intensities below MLSSp reduces subsequent TTF performance, with TTF decreasing linearly as the duration of exercise at MLSSp increases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Hsiang-Han Kao, Hua-Shui Hsu, Tai-Hsien Wu, Hui-Fen Chiang, Hui-Ying Huang, Hui-Ju Wang, Gloria Yang, Wen-Yuan Lin
Summary: Both high-intensity and low-intensity exercise patterns benefit insulin sensitivity, with significant improvements in the obese group observed with short-duration high-intensity exercise. The adiponectin/leptin ratio increased significantly only among normal weight participants with the low-intensity exercise intervention.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Agriculture, Dairy & Animal Science
Hae Sung Lee, Jae Hwan Kim, Hyun Ju Oh, Jong Hee Kim
Summary: In this study, interval exercise training in dogs led to increased bone mineral density (BMD) in the femur and higher levels of serum total alkaline phosphatase (TALP), aspartate aminotransferase, and creatine kinase. The positive relationship between BMD and TALP suggests that increased TALP levels may play a role in enhancing BMD with exercise in dogs.
Article
Pharmacology & Pharmacy
Yan Yan, Zhengzhen Wang, Yan Wang, Xuemei Li
Summary: The study investigated the effects of different durations of moderate-intensity exercise on blood pressure and endothelial function in young male patients with hypertension. Results showed that both 20-minute and 40-minute exercise sessions could reduce blood pressure and improve endothelial function, with the effects of the 40-minute session being superior.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Endocrinology & Metabolism
Valeria L. G. Panissa, David H. Fukuda, Victor Staibano, Marcelo Marques, Emerson Franchini
Summary: This systematic review found that the EPOC of high-intensity interval exercise and sprint interval exercise is significantly higher than moderate-intensity continuous exercise, with long-duration evaluation showing higher EPOC for high-intensity interval exercise compared to moderate-intensity continuous exercise. However, more standardized methodologies are needed to determine the effective EPOC time.
Article
Psychology, Multidisciplinary
Hong Mou, Shudong Tian, Qun Fang, Fanghui Qiu
Summary: This study compares the effects of moderate-intensity continuous exercise (MICE) and high-intensity interval exercise (HIIE) on working memory and finds that HIIE has longer-lasting positive effects on working memory compared to MICE.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Physiology
Antonis Kesisoglou, Andrea Nicolo, Louis Passfield
Summary: The study aimed to compare the effects of different cycling exercise intensities and durations on subsequent performance and found that there was an acute performance decrement (APD) after initial exercise bouts, which did not correspond with total work done (TWD) and training-load (TL) metrics.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2021)
Article
Health Care Sciences & Services
Doowon Lee, Ju-Yeon Son, Hyo-Myeong Ju, Ji-Hee Won, Seung-Bo Park, Woo-Hwi Yang
Summary: This study aimed to investigate the impact of low-intensity exercise of different durations on recovery ability in adults, with the findings suggesting that engaging in at least 1 hour of low-intensity exercise can improve recovery ability.
Article
Physiology
T. J. Herda, J. D. Miller, M. A. Trevino, E. M. Mosier, P. M. Gallagher, A. C. Fry, J. P. Vardiman
Article
Clinical Neurology
Z. A. Graham, W. Qin, L. C. Harlow, N. H. Ross, W. A. Bauman, P. M. Gallagher, C. P. Cardozo
Article
Sport Sciences
Jacob A. Siedlik, Charles Bergeron, Michael Cooper, Russell Emmons, William Moreau, Dustin Nabhan, Philip Gallagher, John P. Vardiman
JOURNAL OF ATHLETIC TRAINING
(2016)
Article
Neurosciences
Michael A. Trevino, Trent J. Herda, Andrew C. Fry, Philip M. Gallagher, John P. Vardiman, Eric M. Mosier, Jonathan D. Miller
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2016)
Article
Neurosciences
Michael A. Trevino, Trent J. Herda, Andrew C. Fry, Philip M. Gallagher, John P. Vardiman, Eric M. Mosier, Jonathan D. Miller
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Meeting Abstract
Sport Sciences
Max J. Tilden, Anthony B. Ciccone, Jake A. Deckert, Cory R. Schlabs, Tercio A. R. Barros, Phillip M. Gallagher, Trent J. Herda, Joseph P. Weir
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2016)
Meeting Abstract
Sport Sciences
Cory R. Schlabs, Anthony B. Ciccone, Jake A. Deckert, Max J. Tilden, Tercio A. R. Barros, Phillip M. Gallagher, Trent J. Herda, Joseph P. Weir
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2016)
Article
Psychology, Biological
Jacob A. Siedlik, Jake A. Deckert, Aaron W. Clopton, Nicole Gigliotti, Marcia A. Chan, Stephen H. Benedict, Trent J. Herda, Philip M. Gallagher, John P. Vardiman
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Biochemical Research Methods
Jacob A. Siedlik, Jake A. Deckert, Stephen H. Benedict, Anuja Bhatta, Amanda J. Dunbar, John P. Vardiman, Philip M. Gallagher
JOURNAL OF IMMUNOLOGICAL METHODS
(2017)
Article
Psychology, Applied
Jacob A. Siedlik, Jake A. Deckert, Aaron W. Clopton, Trent J. Herda, Joseph P. Weir, Philip M. Gallagher, John Phillip Vardiman
Summary: The study aimed to quantify changes in ethical decision-making following Marine Corps Martial Arts Program (MCMAP) training. Results showed that moral intention was acutely impaired post training, and both moral intention and moral judgement worsened over time during training, indicating a functional change in ethical decision-making.
Article
Physiology
Matthew P. Bubak, Kevan Stout, Julia Tomtschik, Ethan Peterson, Christopher P. Cardozo, Zachary A. Graham, Philip Gallagher
Summary: This study found that acute exercise-induced muscle damage leads to an increase in Notch1 gene expression in human skeletal muscle, while Numb and Numb-like expression remains unchanged. These results suggest that the response of human skeletal muscle to exercise-induced muscle damage is dynamic and may differ from other animal models.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Sport Sciences
M. T. Lane, T. J. Herda, A. C. Fry, M. A. Cooper, M. J. Andre, P. M. Gallagher
Article
Sport Sciences
Jacob A. Siedlik, Spyros Siscos, Karen Evans, Adam Rolf, Philip Galagher, Jennifer Seeley, John Vardiman
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
Catherine A. Hambleton, Michael Trevino, Trent Herda, Philip M. Gallagher
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)