IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation

Effector T cell differentiation: are master regulators of effector T cells still the masters?

(2015) Chao Wang et al.   CURRENT OPINION IN IMMUNOLOGY

The immunosuppressive enzyme IL4I1 promotes FoxP3+regulatory T lymphocyte differentiation

(2015) Céline Cousin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination

(2015) A. Doring et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

(2015) Yinpu Yue et al.   PLoS One

Relapsing and progressive forms of multiple sclerosis

(2014) Ranjan Dutta et al.   CURRENT OPINION IN NEUROLOGY

Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice

(2014) Xing-Mei Zhang et al.   GLIA

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Identification and validation of suitable reference genes for RT-qPCR analysis in mouse testis development

(2014) Zu-Kang Gong et al.   MOLECULAR GENETICS AND GENOMICS

IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells

(2013) Veronica Santarlasci et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity

(2013) Ulf Schulze-Topphoff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Antibacterial Properties of the Mammalian L-Amino Acid Oxidase IL4I1

(2013) Marie-Line Puiffe et al.   PLoS One

Matrix metalloproteinase-12 deficiency ameliorates the clinical course and demyelination in Theiler’s murine encephalomyelitis

(2012) Florian Hansmann et al.   ACTA NEUROPATHOLOGICA

Isolation of cortical mouse oligodendrocyte precursor cells

(2012) Toros A. Dincman et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

IL4I1: an inhibitor of the CD8+ antitumor T-cell response in vivo

(2011) Fanette Lasoudris et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies

(2010) Dirk Fitzner et al.   Current Neuropharmacology

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

(2008) J.-C. Corvol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA