Article
Agronomy
Hong Zhou, Yeshuang Ning, Yufan Jian, Miao Zhang, Matthana Klakong, Fuyou Guo, Qingyi Shao, Yanhong Li, Pinglong Yang, Zongquan Li, Liang Yang, Shili Li, Wei Ding
Summary: This study found that the acaricidal mechanism of scopoletin involves the inhibition of the transcription factor SoxNeuroA, which induces the activation of the Orai1 Ca2+ channel, ultimately leading to Ca2+ overload and lethality. This important finding has significant implications for the design of next-generation environmentally friendly acaricides with novel targets.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Ping Cai, Yuanyuan Zhang, Mu Yang, Chenghao Zhang, Mingxia Li, Wei Xiao, Zhifeng Xu, Yongqiang Zhang
Summary: This study identified TcOct beta 2R as the main target gene of amitraz in Tetranychus cinnabarinus and revealed that the difference in acaricidal activity between amitraz and DPMF was due to the divergence of target binding. These results revealed the physiological and pharmacological functions of octopamine receptors in T. cinnabarinus and could provide a basis for the design of new acaricides, with octopamine receptors as a special target.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Hong Zhou, Fuyou Guo, Jinxiang Luo, Yongqiang Zhang, Jinlin Liu, Yanchun Zhang, Xinyu Zheng, Fenglin Wan, Wei Ding
Summary: The study reveals that curcumin disrupts calcium homeostasis in Tetranychus cinnabarinus by activating the expression of the CaM gene, thereby exhibiting acaricidal activity against the mites. The findings suggest a novel target mechanism for new acaricides and enhance understanding of the molecular mechanisms of CaM-mediated acaricide targets in mites.
PEST MANAGEMENT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Guang-Mao Shen, Ting Ma, Xing-Ru Chen, Li Chen, Guang-Ming Liu, Yan-Jie Luo, Michael Adang, Lin He
Summary: This study reveals that TcRXR1 is a specific RNAi target for controlling T. cinnabarinus. Continuous feeding of dsTcRXR1 allows larvae to successfully develop into adults, but increases the mortality rate of eggs. Transcriptome analysis identifies TcCHT-E as a downstream gene of TcRXR1, and its high expression level in the late stage of egg suggests its involvement in chitin metabolism and egg hatching. Both dsTcCHT-E and dsTcRXR1 lead to the death of eggs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hong Zhou, Jinlin Liu, Fenglin Wan, Fuyou Guo, Yeshuang Ning, Sisi Liu, Wei Ding
Summary: Scoparone, derived from Artemisia capillaris, effectively inhibits oviposition of Tetranychus cinnabarinus mites by reducing vitellogenin gene expression, potentially serving as a biopesticide in agriculture to control pests with strong egg-laying capacity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hong Zhou, Sisi Liu, Fenglin Wan, Yufan Jian, Fuyou Guo, Juanni Chen, Yeshuang Ning, Wei Ding
Summary: Graphene oxide (GO) as a promising synergistic agent of pesticides enhances the efficiency of acaricides by affecting the cuticle permeability of mites. Silencing the CPR gene mediates the synergistic effects of GO on acaricides, reducing the use of chemical acaricides in agriculture.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Agriculture, Multidisciplinary
Kaiyang Feng, Zhixin Jiang, Peilin Liu, Jie Liu, Xiang Wen, Lin He
Summary: This study identified and investigated the influence of circular RNA on pesticide resistance evolution in Tetranychus cinnabarinus. It was found that the overexpressed circ1-3p promotes the expression of TcGSTm04 by sponging miR-1-3p, thereby being involved in the evolution of cyflumetofen resistance in T. cinnabarinus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Hong Zhou, Fenglin Wan, Fuyou Guo, Jinlin Liu, Wei Ding
Summary: This study systematically explored the potential molecular targets of scoparone against Tetranychus cinnabarinus, revealing that scoparone activates the CaM1 and L-VGCC-mediated Ca2+ signaling pathways to exert acaricidal effects. The study may contribute to the development of target-specific green acaricidal compounds based on L-VGCC.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemical Research Methods
S. Wenceslao Evans, Dong-Qing Shi, Mariya Chavarha, Mark H. Plitt, Jiannis Taxidis, Blake Madruga, Jiang Lan Fan, Fuu-Jiun Hwang, Siri C. van Keulen, Carl-Mikael Suomivuori, Michelle M. Pang, Sharon Su, Sungmoo Lee, Yukun A. Hao, Guofeng Zhang, Dongyun Jiang, Lagnajeet Pradhan, Richard H. Roth, Yu Liu, Conor C. Dorian, Austin L. Reese, Adrian Negrean, Attila Losonczy, Christopher D. Makinson, Sui Wang, Thomas R. Clandinin, Ron O. Dror, Jun B. Ding, Na Ji, Peyman Golshani, Lisa M. Giocomo, Guo-Qiang Bi, Michael Z. Lin
Summary: By inverting the fluorescence-voltage relationship, the photostability of ASAP family genetically encoded voltage indicators (GEVIs) has been enhanced. Two improved GEVIs, ASAP4b and ASAP4e, enable single-trial detection and recording in standard one- and two-photon microscopes with better temporal resolution. They can simultaneously detect voltage and calcium signals and extend the duration of voltage recordings.
Review
Medicine, Research & Experimental
Xinai Zhang, Yuqian Gao, Yutong Zhou, Zhiming Liu, Ruxiu Liu
Summary: Arrhythmia, characterized by abnormal heartbeat rhythms and frequencies, is the leading cause of death in patients with cardiovascular disease, posing a serious risk to human health. Natural drugs and their active ingredients, such as matrine, tetrandrine, and ginsenosides, have been widely used in the treatment of arrhythmia-like diseases due to their unique advantages. This review summarizes the mechanism of action of natural drugs in the treatment of arrhythmia by regulating Ca2+ levels, providing ideas for the innovative development of natural drugs with potential antiarrhythmic efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, Wei Chen, Michael Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu
Summary: During tumor progression, lysosome function is often maladaptively upregulated to meet the high energy demand needed for cancer cell hyper-proliferation and invasion. In metastatic melanoma cells, TRPML1 is dramatically upregulated, and its synthetic agonists can induce necrotic cell death specifically in these cells. This cell death is caused by mitochondria swelling and dysfunction leading to ATP depletion.
Article
Medicine, Research & Experimental
Yean Chun Loh, Chuan Wei Oo, Wan Yin Tew, Xu Wen, Xu Wei, Mun Fei Yam
Summary: This research confirmed the vasorelaxant action of 4-hydroxybenzaldehyde (4HB) and identified multiple pathways through which it achieves this effect, including cGMP and β(2) pathways, M-3-dependent PLC/IP3 pathways, as well as potassium and calcium channels regulation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Lu Xiao, Xing-Juan Chen, Ji-Kang Feng, Wei-Na Li, Shuo Yuan, Ying Hu
Summary: Arrhythmia is a common heart disease caused by cardiac activity and conduction obstacles, leading to abnormal heart rhythm. Calcium overload is recognized as the main cause of arrhythmia through inducing apoptosis in cardiomyocytes. Natural products with activity against calcium signaling and relevant mechanisms have the potential to be developed as safer and more effective anti-arrhythmia drugs. This review provides an inspiration for pharmaceutical chemists to develop more potent calcium channel blockers for the treatment of arrhythmia.
Article
Neurosciences
Shaopeng Chi, Yaxiong Cui, Haiping Wang, Jinghui Jiang, Tingxin Zhang, Suhua Sun, Zhuan Zhou, Yi Zhong, Bailong Xiao
Summary: This study reveals the importance of mechanotransduction mediated by Piezo1 in astrocytes for adult neurogenesis and cognitive functions. Piezo1 in astrocytes mediates mechanically evoked calcium responses and ATP release, and its deficiency leads to severe impairment in brain structure and function.
Review
Pharmacology & Pharmacy
Rumaitha Al-Hosni, Zeki Ilkan, Emilio Agostinelli, Paolo Tammaro
Summary: This article critically analyzes recent developments in TMEM16A pharmacology and discusses the therapeutic opportunities provided by this target.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)