Neuro‐Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

(2019) Haiyan An et al.   Acta Neuropathologica Communications

Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice

(2019) Anna Gorlova et al.   NEUROPHARMACOLOGY

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

(2019) Lara Marrone et al.   ACTA NEUROPATHOLOGICA

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

(2019) Pengfei Zhang et al.   Nature Communications

Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

(2019) Marina V. Kovina et al.   Frontiers in Genetics

Standardized human bone marrow-derived stem cells infusion improves survival and recovery in a rat model of spinal cord injury

(2019) J.P. de Munter et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Dynamic secretome of bone marrow-derived stromal cells reveals a cardioprotective biochemical cocktail

(2019) Kshitiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Labeling of human mesenchymal stem cells with different classes of vital stains: robustness and toxicity

(2019) Anna Andrzejewska et al.   Stem Cell Research & Therapy

Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

(2019) Martin Crivello et al.   Disease Models & Mechanisms

Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

(2019) Ekaterina Veniaminova et al.   LIFE SCIENCES

Mouse models of ALS: Past, present and future

(2018) Cathleen Lutz   BRAIN RESEARCH

Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

(2018) Rajendrarao Sumitha et al.   MOLECULAR NEUROBIOLOGY

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

(2018) Tatyana A. Shelkovnikova et al.   Molecular Neurodegeneration

Neural Crossroads in the Hematopoietic Stem Cell Niche

(2018) Sobhika Agarwala et al.   TRENDS IN CELL BIOLOGY

Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1 G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis

(2018) Carmen Rodríguez-Cueto et al.   BIOCHEMICAL PHARMACOLOGY

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

(2018) Przemysław Duda et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering

(2018) Ross E. B. Fitzsimmons et al.   Stem Cells International

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

(2018) Jone López-Erauskin et al.   NEURON

Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection

(2018) Forouzan Yousefi et al.   JOURNAL OF NEUROIMMUNOLOGY

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

(2017) Pooja-Shree Mishra et al.   Journal of Neuroinflammation

Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets

(2017) Giovanna Morello et al.   MEDIATORS OF INFLAMMATION

Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis

(2017) Sebastiano Giuseppe Crisafulli et al.   MOLECULAR NEUROBIOLOGY

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

(2017) Elena Redondo-Castro et al.   Stem Cell Research & Therapy

Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

(2017) Yang Hu et al.   Scientific Reports

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

(2016) Radu Stoica et al.   EMBO REPORTS

Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting

(2016) Elisse C. Browne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stem cells therapy for ALS

(2016) Letizia Mazzini et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line

(2016) Shanmukha Shruthi et al.   Neurodegenerative Diseases

Breathing pattern in a phase I clinical trial of intraspinal injection of autologous bone marrow mononuclear cells in patients with amyotrophic lateral sclerosis

(2016) Francisco José Ruiz-López et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

FET proteins regulate lifespan and neuronal integrity

(2016) Martine Therrien et al.   Scientific Reports

Human Wharton's Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis

(2015) Raf Donders et al.   CELL TRANSPLANTATION

Phase I Trial of Repeated Intrathecal Autologous Bone Marrow-Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis

(2015) Ki-Wook Oh et al.   Stem Cells Translational Medicine

Animal Models of Depression and Drug Delivery with Food as an Effective Dosing Method: Evidences from Studies with Celecoxib and Dicholine Succinate

(2015) João P. Costa-Nunes et al.   Biomed Research International

Human mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in a mouse model of amyotrophic lateral sclerosis

(2014) Marina Boido et al.   CYTOTHERAPY

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms

(2014) Tatyana A. Shelkovnikova et al.   HUMAN MOLECULAR GENETICS

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia

(2013) Yvonne Couch et al.   BRAIN BEHAVIOR AND IMMUNITY

Mutations in the 3′ untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis

(2013) Mario Sabatelli et al.   HUMAN MOLECULAR GENETICS

Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

(2013) Tatyana A. Shelkovnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress

(2013) Reddy Ranjith K. Sama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Electrophysiologic Biomarkers for Assessing Disease Progression and the Effect of Riluzole in SOD1 G93A ALS Mice

(2013) Jia Li et al.   PLoS One

Synergistic Effects of Celecoxib and Bupropion in a Model of Chronic Inflammation-Related Depression in Mice

(2013) Izaque S. Maciel et al.   PLoS One

The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2

(2012) Brandon H Cline et al.   BMC NEUROSCIENCE

Involvement of Immune Response in the Pathogenesis of Amyotrophic Lateral Sclerosis: A Therapeutic Opportunity?

(2012) A. Calvo et al.   CNS & Neurological Disorders-Drug Targets

70th Birthday symposium of Prof. Dr. Riederer: autologous adult stem cells in ischemic and traumatic CNS disorders

(2012) Johannes P. J. M. de Munter et al.   JOURNAL OF NEURAL TRANSMISSION

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(2012) Antonio Uccelli et al.   MOLECULAR MEDICINE

RNA targets of wild-type and mutant FET family proteins

(2011) Jessica I Hoell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Paraspeckles

(2010) A. H. Fox et al.   Cold Spring Harbor Perspectives in Biology

FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis

(2009) I. P. Blair et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neural Induction with Neurogenin1 Increases the Therapeutic Effects of Mesenchymal Stem Cells in the Ischemic Brain

(2008) Sung-Soo Kim et al.   STEM CELLS