Article
Clinical Neurology
Keaton N. Ott, Arada Chaiyamoon, Juan J. Cardona, Francisco Reina, Ana Carrera, Joe Iwanaga, Aaron S. Dumont, Juan E. Small, R. Shane Tubbs
Summary: This study investigated the anatomical and histological features of the tentorial sinuses (TS) using microsurgical dissection and histology. Two types of TS were identified, namely, a small intrinsic plexiform sinus (Type 1) and a larger tentorial sinus with direct connections to the bridging veins from the cerebral and cerebellar hemispheres (Type 2). The TS showed important connections to other venous sinuses. These novel findings have significant implications for surgical procedures and pathological diagnosis.
WORLD NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Hidenori Tabata, Daisuke Mori, Tohru Matsuki, Kaichi Yoshizaki, Masato Asai, Atsuo Nakayama, Norio Ozaki, Koh-ichi Nagata
Summary: 22q11.2 deletion syndrome (22q11.2DS) is associated with a high risk of psychiatric and developmental disorders. A mouse model of this disease, Del(3.0Mb)/+, was generated and its behavior was extensively studied. The histological features of the brains of Del(3.0Mb)/+ mice were investigated and changes were observed in the morphology of individual neurons in specific brain regions. These changes in the dopamine system may explain the abnormal behaviors of the mice and the psychiatric symptoms of 22q11.2DS.
Article
Anatomy & Morphology
Michael Snosek, Veronica Macchi, Carla Stecco, R. Shane Tubbs, Raffaele De Caro, Marios Loukas
Summary: The alar fascia is a constant and independent coronal fascial layer located between the carotid sheaths. It contains neurovasculature and may limit the spread of retropharyngeal infections into the thorax as well as facilitate normal physiological functions of the cervical viscera.
Article
Biology
Alexandra Fochtmann-Frana, Bettina Pretterklieber, Christine Radtke, Michael L. Pretterklieber, Huang-Ping Yu
Summary: This study provides a detailed examination of the phrenic nerve, revealing differences in length between the left and right sides and the presence of accessory phrenic nerves. The study also shows a negative correlation between the number of axons in the phrenic nerves and age. The findings highlight the importance of preserving the accessory phrenic nerve.
Article
Surgery
Loubin Si, Hairui Li, Zhijin Li, Mingzi Zhang, Xi Chen, Lu Yu, Hayson Chenyu Wang, Yang Wang
Summary: This study aims to better understand the anatomical characteristics of the back and propose evidence-based zoning principles for liposuction-assisted back contouring. The study found that the superficial fascial system (SFS) in the back has regional variations in density and tissue structure, which are consistent with observed back contour deformities in Asian female patients. Understanding the topographic anatomy of the back is crucial for improving surgical precision and avoiding dorsal contour deformity.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anando Sen, Natalie W. Fowlkes, Charles Kingsley, Adam M. Kulp, Thomas Huynh, Brandy J. Willis, Kari J. Brewer Savannah, Mary Catherine A. Bordes, Ken-Pin Hwang, Molly M. McCulloch, Roger Jason Stafford, Alejandro Contreras, Gregory Reece, Kristy K. Brock
Summary: A precise correlation between 3D imaging and histology of the breast can aid biomechanical modeling. By using a novel cryo-fluorescence tomography device, ex vivo breast images were accurately registered to histology. The statistically significant differences in MR signal intensities between histological tissues serve as indicators for the specificity of correlation between MRI and histology.
Review
Urology & Nephrology
Charles Botter, Megane Botter, Chiara Pizza, Cecile Charpy, Virginie Pineau, Simone La Padula, Jean-Paul Meningaud, Barbara Hersant
Summary: The suspensory ligament of the clitoris is a multidimensional structure consisting of three anatomically and histologically distinct components, which plays a significant role in understanding female orgasm and sexuality.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Cell Biology
Yanping Huang, Xiangping Li, Xiangzhou Sun, Jiahui Yao, Fengxin Gao, Zhenqing Wang, Jiaying Hu, Zhu Wang, Bin Ouyang, Xiangan Tu, Xuenong Zou, Wei Liu, Mujun Lu, Chunhua Deng, Qiyun Yang, Yun Xie
Summary: This study investigates the phenotypes and transcriptomes of different regions of the male mouse reproductive tract to explore the mechanisms underlying reproductive aging. It identifies region-specific genes and highlights the role of immune response-associated factors in male reproductive aging. The findings contribute to our understanding of male reproductive aging and infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Jean-Baptiste Marret, Thomas Blanc, Andre Balaton, Sandro La Vignera, Guido Zanghi, Henri Bernard Lottmann, Vincenzo Bagnara
Summary: Symptomatic parapelvic cysts (PPC) are rare and can be misdiagnosed as UPJ obstruction. This study retrospectively reviewed the records of children managed between 2012-2017. The results showed that ultrasound and other imaging exams are crucial for the diagnosis of PPC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Kwang-Hoon Chun
Summary: Adipose tissue plays crucial roles in energy storage, hormone secretion, and temperature regulation. Mice are widely used in metabolic studies, but the diversity and characteristics of adipose tissue have not been comprehensively summarized yet.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Cell Biology
Mayra L. Ruiz Tejada Segura, Eman Abou Moussa, Elisa Garabello, Thiago S. Nakahara, Melanie Makhlouf, Lisa S. Mathew, Li Wang, Filippo Valle, Susie S. Y. Huang, Joel D. Mainland, Michele Caselle, Matteo Osella, Stephan Lorenz, Johannes Reisert, Darren W. Logan, Bettina Malnic, Antonio Scialdone, Luis R. Saraiva
Summary: This study created a genome-wide 3D atlas of the mouse olfactory mucosa using spatial transcriptomics. The distribution of odorant receptor genes (Olfrs) and non-Olfrs in different regions was found to be continuous and overlapping. The spatial locations of Olfrs correlated with the solubility of the odorants they recognized, providing evidence for the chromatographic theory of olfaction.
Article
Veterinary Sciences
Kirsten Proost, Carsten Staszyk, Matthieu N. Boone, Jorg Vogelsberg, Ivan Josipovic, Lieven Vlaminck, Koen Chiers
Summary: Scientific literature on veterinary dentistry in alpacas has historically focused on tooth root abscesses, but recent studies have discovered a variety of other dental conditions in this species. A more thorough understanding of the underlying etiopathogenesis of dental disease is needed to develop effective treatment strategies. Histological studies on normal dental tissues can serve as a basis for this purpose.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Patricia P. Yee, Jianli Wang, Stephen Y. Chih, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Krishnamoorthy Thamburaj, Wei Li
Summary: Tumor necrosis is a poor prognostic marker in GBM and other solid cancers. The radiological features of early necrosis formation and its relationship with tumor progression are poorly understood. This study used a mouse model to investigate necrosis development and found that actively necrotic tumor tissue appears brighter in the early stages of progression. As tumor progresses, the central necrotic portion shows loss of enhancement on MRI. The development of necrosis is associated with inflammation, with neutrophils being the predominant immune cell population.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Oliver Meikar, Daniel Majoral, Olli Heikkinen, Eero Valkama, Sini Leskinen, Ana Rebane, Pekka Ruusuvuori, Jorma Toppari, Juho-Antti Makela, Noora Kotaja
Summary: Spermatogenesis is a complex differentiation process that occurs in the seminiferous tubules. A specific organization of spermatogenic cells within the seminiferous epithelium allows for synchronous progression of germ cells at certain stages of differentiation. To facilitate the analysis of spermatogenesis, researchers have developed a convolutional deep neural network-based approach called STAGETOOL. STAGETOOL accurately classifies histological images of DAPI-stained mouse testis cross-sections into different stage classes and cell categories. It has high classification accuracy and can be applied for analyzing spermatogenic defects in knockout mouse models and profiling protein expression patterns. STAGETOOL represents a major advancement in male reproductive biology research.
Article
Anatomy & Morphology
Joe Iwanaga, Puhan He, Keiko Fukino, Mi-Sun Hur, Hee-Jin Kim, Aya Han, Koichi Watanabe, Soichiro Ibaragi, Norio Kitagawa, R. Shane Tubbs
Summary: The anatomy of the superior labial frenulum involves a mucosal fold between the gingival mucosa and alveolar mucosa, which is associated with the incisivus labii superioris. Understanding the anatomical relationship between these structures is crucial in studying the superior labial frenulum.