A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors

Natural products as inhibitors of prostaglandin E 2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

(2018) Andreas Koeberle et al.   BIOTECHNOLOGY ADVANCES

Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

(2018) Stefania Terracciano et al.   CHEMICAL COMMUNICATIONS

Discovery of new potent molecular entities able to inhibit mPGES-1

(2018) Simone Di Micco et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

(2017) Gianluigi Lauro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship

(2017) Mohd. Javed Naim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of Microsomal Prostaglandin E2Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

(2016) Gianluigi Lauro et al.   ChemMedChem

Anti-inflammatory trends of new benzimidazole derivatives

(2016) Syed Nasir Abbas Bukhari et al.   Future Medicinal Chemistry

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

(2016) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E2synthase

(2016) Joseph S. Brock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

(2015) Andreas Koeberle et al.   BIOCHEMICAL PHARMACOLOGY

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors

(2015) Matthew A. Schiffler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors

(2015) Mehrdad Iranshahi et al.   JOURNAL OF NATURAL PRODUCTS

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

(2015) Stefania Terracciano et al.   ACS Medicinal Chemistry Letters

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

(2014) Dianfan Li et al.   CRYSTAL GROWTH & DESIGN

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

(2014) Gianluigi Lauro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

(2013) T. Sjogren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

(2011) Rosa De Simone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

(2011) Thomas Mendgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

mPGES-1 as a target for cancer suppression

(2010) Masako Nakanishi et al.   BIOCHIMIE

Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense

(2010) U Siemoneit et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer

(2010) O. Rådmark et al.   JOURNAL OF INTERNAL MEDICINE

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

(2009) Andreas Koeberle et al.   BIOCHEMICAL PHARMACOLOGY

Rhodanine as a Privileged Scaffold in Drug Discovery

(2009) T. Tomasic et al.   CURRENT MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS