Structure-Based Design of Microsomal Prostaglandin E2Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study

(2016) Minju Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

(2015) Stefan M. Noha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors

(2015) Matthew A. Schiffler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

(2015) John Gately Luz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors

(2015) Mehrdad Iranshahi et al.   JOURNAL OF NATURAL PRODUCTS

Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment

(2015) Karin Larsson et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

(2015) Maria Giovanna Chini et al.   MedChemComm

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

(2015) Stefania Terracciano et al.   ACS Medicinal Chemistry Letters

Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation

(2014) Kamal Rullah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

(2014) Dianfan Li et al.   CRYSTAL GROWTH & DESIGN

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1)

(2014) Gianluigi Lauro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo

(2013) Thomas Hanke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

(2013) T. Sjogren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

(2012) Maria Giovanna Chini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Novel Matrix Metalloproteinase Inhibitors by Screening of Phenol Fragments Library

(2011) Maria Teresa Rubino et al.   ARCHIV DER PHARMAZIE

Identification and development of mPGES-1 inhibitors: where we are at?

(2011) Hui-Hua Chang et al.   Future Medicinal Chemistry

Structure-Based Discovery of Inhibitors of Microsomal Prostaglandin E2Synthase−1, 5-Lipoxygenase and 5-Lipoxygenase-Activating Protein: Promising Hits for the Development of New Anti-inflammatory Agents

(2011) Rosa De Simone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2Synthase-1 (mPGES-1)

(2011) Birgit Waltenberger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prostaglandin E2 Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression

(2011) Karina Roxana Gheorghe et al.   PLoS One

mPGES-1 as a target for cancer suppression

(2010) Masako Nakanishi et al.   BIOCHIMIE

Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes

(2010) Shu-Huang Chen et al.   ARTHRITIS RESEARCH & THERAPY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

(2009) A. Koeberle et al.   CURRENT MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human Microsomal Prostaglandin E Synthase-1 (mPGES-1) Binding with Inhibitors and the Quantitative Structure−Activity Correlation

(2007) Mohamed Diwan M. AbdulHameed et al.   Journal of Chemical Information and Modeling