Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles

Radical Addition to Strained σ-Bonds Enables the Stereocontrolled Synthesis of Cyclobutyl Boronic Esters

(2019) Mattia Silvi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: “BCP-F2”

(2019) Xiaoshen Ma et al.   ORGANIC LETTERS

Photochemical Strain-Release-Driven Cyclobutylation of C(sp3 )-Centered Radicals

(2019) Guillaume Ernouf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization

(2019) Roman M. Bychek et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient and Stable Strain-Release Radioiodination for Thiol Chemoselective Bioconjugation

(2018) Pu Zhang et al.   BIOCONJUGATE CHEMISTRY

Enzymatic construction of highly strained carbocycles

(2018) Kai Chen et al.   SCIENCE

Cubanes in Medicinal Chemistry

(2018) Tristan A. Reekie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbopalladation of C–C σ-bonds enabled by strained boronate complexes

(2018) Alexander Fawcett et al.   Nature Chemistry

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

(2017) Justin M. Lopchuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine B

(2016) Robert A. Panish et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

(2016) Benjamin A. Chalmers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Methoxy-N-methylcyanoformamide, a Highly Reactive Reagent for the Formation of β-Keto Weinreb Amides and Unsymmetrical Ketones

(2016) Jeremy Nugent et al.   ORGANIC LETTERS

Strain-release amination

(2016) R. Gianatassio et al.   SCIENCE

Ring-Strain-Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes

(2015) Maciej A. A. Walczak et al.   ACCOUNTS OF CHEMICAL RESEARCH

One-pot Unsymmetrical Ketone Synthesis Employing a Pyrrole-Bearing Formal Carbonyl Dication Linchpin Reagent

(2015) Stephen T. Heller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Cyclobutanes via Sequential Rh-catalyzed Bicyclobutanation/Cu-catalyzed Homoconjugate Addition

(2013) Robert Panish et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of 2-Arylbicyclo[1.1.0]butane Carboxylates

(2013) Changming Qin et al.   ORGANIC LETTERS

Synthesis of cyclopropane compounds: bicyclo[1.1.0]butanes, spiropentanes and bicyclopropanes

(2012) Ilfir R Ramazanov et al.   RUSSIAN CHEMICAL REVIEWS

Bioconjugation with Strained Alkenes and Alkynes

(2011) Marjoke F. Debets et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium(I)-Catalyzed Cycloisomerizations of Bicyclobutanes

(2008) Maciej A. A. Walczak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY