The Development Process: from SAHA to Hydroxamate HDAC Inhibitors with Branched CAP Region and Linear Linker

Epigenetic Targets and Their Inhibitors in Cancer Therapy

(2019) Le Zhao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis and activity evaluation of indole-based double – Branched HDAC1 inhibitors

(2019) Qiuqiong Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status

(2018) Xiaoyang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deregulated expression of HDAC3 in colorectal cancer and its clinical significance

(2018) Masoumeh Nemati et al.   Advances in Clinical and Experimental Medicine

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors

(2018) Rekha Sangwan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy

(2018) Yepeng Luan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview

(2018) Suvankar Banerjee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening, ADMET prediction and molecular dynamics simulation assay

(2017) Abdullahi Ibrahim Uba et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

(2017) Viktoria Krieger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

(2017) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

(2017) Katharina Stenzel et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Search for Potent, Small-Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat

(2017) Chiara Zagni et al.   MEDICINAL RESEARCH REVIEWS

Inhibitors of histone deacetylase as antitumor agents: A critical review

(2016) Mohammed Manal et al.   BIOORGANIC CHEMISTRY

Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia

(2016) Elena Ceccacci et al.   BRITISH JOURNAL OF CANCER

Lost in translation? Ten years of development of histone deacetylase inhibitors in acute myeloid leukemia and myelodysplastic syndromes

(2016) Maximilian Stahl et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

How do tumor cells respond to HDAC inhibition?

(2016) Andrea Newbold et al.   FEBS Journal

Histone deacetylase inhibitors in multiple myeloma: from bench to bedside

(2016) Takeshi Harada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

(2016) Yong Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comparative study based on docking and molecular dynamics simulations over HDAC-tubulin dual inhibitors

(2016) Malihe Hassanzadeh et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer

(2016) N Stojanovic et al.   ONCOGENE

Exploiting histone deacetylases for cancer therapy: from hematological malignancies to solid tumors

(2016) Min Huang et al.   Science China-Life Sciences

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Perspectives in the development of hybrid bifunctional antitumour agents

(2015) Loana Musso et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity

(2015) Wenwen Duan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents

(2015) Jin Cai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective Inhibitors of Zinc-Dependent Histone Deacetylases. Therapeutic Targets Relevant to Cancer

(2015) Jakub Kollar et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging approaches for histone deacetylase inhibitor drug discovery

(2015) Clemens Zwergel et al.   Expert Opinion on Drug Discovery

HDAC Inhibitors as Novel Anti-Cancer Therapeutics

(2015) Cristabelle Souza et al.   Recent Patents on Anti-Cancer Drug Discovery

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

(2015) Lisa Zhang et al.   Oncotarget

Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif

(2014) Peng Guan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Histone deacetylase inhibitors in cancer: What have we learned?

(2014) James R. Whittle et al.   CANCER

Design and Optimization of Novel Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-Substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis

(2014) Feifei Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells

(2014) Li-Jun Miao et al.   TUMOR BIOLOGY

Selectively Targeting Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors

(2013) Berkley E. Gryder et al.   ACS Chemical Biology

Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors

(2013) Maurizio Taddei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2013) Nguyen-Hai Nam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Dual-Action Inhibitors Targeting Histone Deacetylases and 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase for Cancer Treatment

(2013) Jhih-Bin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Benzothiazole/thiazole-Containing Hydroxamic Acids as Potent Histone Deacetylase Inhibitors and Antitumor Agents

(2013) Truong Tung et al.   Medicinal Chemistry

Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases

(2013) Florence F. Wagner et al.   Neurotherapeutics

Development of a Chimeric c-Src Kinase and HDAC Inhibitor

(2013) Kristin S. Ko et al.   ACS Medicinal Chemistry Letters

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

(2012) Peng Guan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

(2012) L. Santo et al.   BLOOD

Design, Synthesis, and Biological Activity of Hydroxamic Tertiary Amines as Histone Deacetylase Inhibitors

(2012) Stefania Terracciano et al.   ChemMedChem

Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents

(2011) Dao Thi Kim Oanh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group

(2011) Yingjie Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes

(2011) Raghupathi Neelarapu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

(2010) Jiahuai Tan et al.   Journal of Hematology & Oncology

Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents

(2010) Rong He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Identification of Hydroxamate HDAC 1 Inhibitors

(2009) Liqin YU et al.   CHINESE JOURNAL OF CHEMISTRY

From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage

(2008) S. Giordano et al.   CURRENT MEDICINAL CHEMISTRY

Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR

(2008) Victor Andrianov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

(2008) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells andPlasmodium falciparum

(2008) Yufeng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY