Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity

Molecular architectures of Pen and Pal: Key enzymes required for CMP-pseudaminic acid biosynthesis in Bacillus thuringiensis

(2018) Nathan A. Delvaux et al.   PROTEIN SCIENCE

EGFR Downregulation after Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer

(2017) Yasuyuki Okada et al.   MOLECULAR CANCER RESEARCH

Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC

(2017) Kumar Perinbam et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships

(2015) Chitra Bhatia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis

(2015) Sourish Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

(2015) Stephen B. Helliwell et al.   Nature Communications

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

(2015) Linara Gabitova et al.   Cell Reports

How to balance cardiorenometabolic benefits and risks of statins

(2014) Soo Lim et al.   ATHEROSCLEROSIS

Structural insights into substrate and coenzyme preference by SDR family protein Gox2253 fromGluconobateroxydans

(2014) Bo Yin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroidal Triterpenes of Cholesterol Synthesis

(2013) Jure Ačimovič et al.   MOLECULES

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

(2013) S. Rousseaux et al.   Science Translational Medicine

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation

(2012) Anna Sukhanova et al.   Cancer Discovery

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

(2011) H. Okayama et al.   CANCER RESEARCH

Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay

(2011) Miao He et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression profile of NSDHL in human peripheral tissues

(2011) Marie Morimoto et al.   JOURNAL OF MOLECULAR HISTOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hypomorphic Temperature-Sensitive Alleles of NSDHL Cause CK Syndrome

(2010) Keith W. McLarren et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

(2008) Kerby Shedden et al.   NATURE MEDICINE