Epigenetic regulation of centromere function

Phosphorylation of CENP-A on serine 7 does not control centromere function

(2019) Viviana Barra et al.   Nature Communications

Point centromere activity requires an optimal level of centromeric noncoding RNA

(2019) Yick Hin Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

(2019) Yael Nechemia-Arbely et al.   NATURE CELL BIOLOGY

Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A Cnp1 -Specific Assembly Factor through Eic1 Interaction

(2018) Sojin An et al.   STRUCTURE

Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue

(2018) Grégory Eot-Houllier et al.   Nature Communications

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly

(2017) Ana Stankovic et al.   MOLECULAR CELL

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

(2017) Gloria Jih et al.   NATURE

Chromatin dynamics during the cell cycle at centromeres

(2017) Sebastian Müller et al.   NATURE REVIEWS GENETICS

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

(2017) Minh Bui et al.   Epigenetics & Chromatin

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

(2017) Dongqing Pan et al.   eLife

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions

(2016) Adina Gerson-Gurwitz et al.   CELL

The CENP-T/-W complex is a binding partner of the histone chaperone FACT

(2016) Lisa Prendergast et al.   GENES & DEVELOPMENT

Mitotic noncoding RNA processing promotes kinetochore and spindle assembly inXenopus

(2016) Andrew W. Grenfell et al.   JOURNAL OF CELL BIOLOGY

Promiscuous Histone Mis-Assembly Is Actively Prevented by Chaperones

(2016) Haiqing Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SUMO-targeted ubiquitin ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin

(2016) Kentaro Ohkuni et al.   MOLECULAR BIOLOGY OF THE CELL

Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres

(2016) Wei-Hao Shang et al.   Nature Communications

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

(2016) Oscar Molina et al.   Nature Communications

RbAp46/48LIN-53 Is Required for Holocentromere Assembly in Caenorhabditis elegans

(2016) Bernard Chi Hang Lee et al.   Cell Reports

SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability

(2016) Chao Huang et al.   Cell Reports

Centromeric Transcription Regulates Aurora-B Localization and Activation

(2016) Michael D. Blower   Cell Reports

The ultrastructure of mono- and holocentric plant centromeres: an immunological investigation by structured illumination microscopy and scanning electron microscopy

(2015) Gerhard Wanner et al.   CHROMOSOMA

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription

(2015) Chin-Chi Chen et al.   DEVELOPMENTAL CELL

Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres

(2015) Zhouliang Yu et al.   DEVELOPMENTAL CELL

Both tails and the centromere targeting domain of CENP-A are required for centromere establishment

(2015) Glennis A. Logsdon et al.   JOURNAL OF CELL BIOLOGY

Identification of the Post-translational Modifications Present in Centromeric Chromatin

(2015) Aaron O. Bailey et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

(2015) Rajbir K Athwal et al.   Epigenetics & Chromatin

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

(2015) Sandra Catania et al.   PLoS Genetics

RNAi pathway participates in chromosome segregation in mammalian cells

(2015) Chuan Huang et al.   Cell Discovery

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres

(2014) Kara L. McKinley et al.   CELL

Neocentromeres

(2014) Tatsuo Fukagawa et al.   CURRENT BIOLOGY

Anti-Phosphorylated Histone H2AThr120: A Universal Microscopic Marker for Centromeric Chromatin of Mono- and Holocentric Plant Species

(2014) D. Demidov et al.   CYTOGENETIC AND GENOME RESEARCH

The E3 Ligase CUL3/RDX Controls Centromere Maintenance by Ubiquitylating and Stabilizing CENP-A in a CAL1-Dependent Manner

(2014) Debora Bade et al.   DEVELOPMENTAL CELL

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

(2014) Tetsuya Hori et al.   DEVELOPMENTAL CELL

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

Involvement of satellite I noncoding RNA in regulation of chromosome segregation

(2014) Takashi Ideue et al.   GENES TO CELLS

Mitotic Regulator Mis18β Interacts with and Specifies the Centromeric Assembly of Molecular Chaperone Holliday Junction Recognition Protein (HJURP)

(2014) Jianyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CAL1 is theDrosophilaCENP-A assembly factor

(2014) Chin-Chi Chen et al.   JOURNAL OF CELL BIOLOGY

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3CENP-A Loading

(2014) Sebastian Müller et al.   Cell Reports

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

The Past, Present, and Future of Human Centromere Genomics

(2014) Megan Aldrup-MacDonald et al.   Genes

Protection of Germline Gene Expression by the C. elegans Argonaute CSR-1

(2013) Christopher J. Wedeles et al.   DEVELOPMENTAL CELL

Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

(2013) Wei-Hao Shang et al.   DEVELOPMENTAL CELL

Efficient neocentromere formation is suppressed by gene conversion to maintain centromere function at native physical chromosomal loci in Candida albicans

(2013) J. Thakur et al.   GENOME RESEARCH

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function

(2013) D. Goutte-Gattat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational modification of CENP-A influences the conformation of centromeric chromatin

(2013) A. O. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Depletion of Piwi, a Component of the RNAi System, Impacts Heterochromatin Formation in Drosophila

(2013) Tingting Gu et al.   PLoS Genetics

RNA as a Structural and Regulatory Component of the Centromere

(2012) Jonathan I. Gent et al.   Annual Review of Genetics

Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo

(2012) Minh Bui et al.   CELL

Replicating centromeric chromatin: Spatial and temporal control of CENP-A assembly

(2012) Yael Nechemia-Arbely et al.   EXPERIMENTAL CELL RESEARCH

Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

(2012) J. H. Bergmann et al.   JOURNAL OF CELL SCIENCE

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

(2012) Reto Gassmann et al.   NATURE

Transcription in the maintenance of centromere chromatin identity

(2012) F. L. Chan et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of histone H2A is associated with centromere function and maintenance in meiosis

(2012) Qianhua Dong et al.   PLANT JOURNAL

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation

(2012) A. Samel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis

(2012) Lingluo Chu et al.   Journal of Molecular Cell Biology

Factors That Promote H3 Chromatin Integrity during Transcription Prevent Promiscuous Deposition of CENP-ACnp1 in Fission Yeast

(2012) Eun Shik Choi et al.   PLoS Genetics

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

(2011) David Frescas et al.   CELL CYCLE

Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. elegans Embryos

(2011) Karen W.Y. Yuen et al.   CURRENT BIOLOGY

The F Box Protein Partner of Paired Regulates Stability of Drosophila Centromeric Histone H3, CenH3CID

(2011) Olga Moreno-Moreno et al.   CURRENT BIOLOGY

Endogenous Transcription at the Centromere Facilitates Centromere Activity in Budding Yeast

(2011) Kentaro Ohkuni et al.   CURRENT BIOLOGY

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

(2011) Mariana C.C. Silva et al.   DEVELOPMENTAL CELL

A Role for Histone H4K16 Hypoacetylation inSaccharomyces cerevisiaeKinetochore Function

(2011) John S. Choy et al.   GENETICS

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres

(2011) Eun Shik Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XenopusHJURP and condensin II are required for CENP-A assembly

(2011) Rafael Bernad et al.   JOURNAL OF CELL BIOLOGY

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G1phase

(2011) Elaine M. Dunleavy et al.   Nucleus

Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity

(2010) Elizabeth H. Bayne et al.   CELL

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4

(2010) Geetha Hewawasam et al.   MOLECULAR CELL

An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain

(2010) Prerana Ranjitkar et al.   MOLECULAR CELL

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A

(2010) Anaïck Lagana et al.   NATURE CELL BIOLOGY

A super-resolution map of the vertebrate kinetochore

(2010) S. A. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

A paucity of heterochromatin at functional human neocentromeres

(2010) Alicia Alonso et al.   Epigenetics & Chromatin

DNA Binding of Centromere Protein C (CENPC) Is Stabilized by Single-Stranded RNA

(2010) Yaqing Du et al.   PLoS Genetics

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

(2009) Julie M. Claycomb et al.   CELL

Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

(2009) Ingela Djupedal et al.   EMBO JOURNAL

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

(2009) Suhasni Gopalakrishnan et al.   HUMAN MOLECULAR GENETICS

Hierarchical Inactivation of a Synthetic Human Kinetochore by a Chromatin Modifier

(2009) Stefano Cardinale et al.   MOLECULAR BIOLOGY OF THE CELL

CENP-H–containing Complex Facilitates Centromere Deposition of CENP-A in Cooperation with FACT and CHD1

(2009) Masahiro Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Fission Yeast Scm3 Mediates Stable Assembly of Cnp1/CENP-A into Centromeric Chromatin

(2009) Jessica S. Williams et al.   MOLECULAR CELL

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

(2009) Federica Ferri et al.   NUCLEIC ACIDS RESEARCH

Histone Modifications within the Human X Centromere Region

(2009) Brankica Mravinac et al.   PLoS One

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Synthetic Heterochromatin Bypasses RNAi and Centromeric Repeats to Establish Functional Centromeres

(2009) A. Kagansky et al.   SCIENCE

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

(2008) Owen J. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres

(2008) Dawn M. Carone et al.   CHROMOSOMA

Histone modifications associated with both A and B chromosomes of maize

(2008) Weiwei Jin et al.   CHROMOSOME RESEARCH

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

RNA Pol II Promotes Transcription of Centromeric Satellite DNA in Beetles

(2008) Željka Pezer et al.   PLoS One

Genome-Wide Association of Histone H3 Lysine Nine Methylation with CHG DNA Methylation in Arabidopsis thaliana

(2008) Yana V. Bernatavichute et al.   PLoS One

Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres

(2008) H. D. Folco et al.   SCIENCE

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY