Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Cell & Tissue Engineering
Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong, Zhi Zheng
Summary: This study revealed that exosomal miR-27b derived from hucMSCs could reverse the EMT process induced by TGF-beta 2 by inhibiting HOXC6, suggesting the potential therapeutic role of the exosomal miR-27b/HOXC6 axis in ameliorating subretinal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lei Na, Zhuo Wang, Yu Bai, Yu Sun, Dan Dong, Wei Wang, Chenghai Zhao
Summary: This study identified that WNT7B is downregulated in high-grade bladder urothelial carcinomas, and its low expression is associated with poor prognosis. WNT7B inhibits bladder urothelial carcinoma progression by suppressing EMT, stem-like properties, and chemoresistance.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Hadil Onallah, Sheethal Thomas Mannully, Ben Davidson, Reuven Reich
Summary: The study demonstrates the important role of PLD isoenzymes in regulating migration, invasion, metastasis, and EMT in HGSC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Jingwen Jiang, Jiayu Li, Xiumei Zhou, Xueqin Zhao, Biao Huang, Yuan Qin
Summary: Exosomes play an important role in intercellular communication and can regulate the EMT process in tumor cells. They have potential applications in cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jingcui Peng, Sa Li, Bin Li, Wenxia Hu, Cuimin Ding
Summary: This study found that miR-486-5p inhibits lung cancer progression by regulating the expression of MIER3, and this effect is mediated by exosomes carried by mesenchymal stem cells.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yao Li, Quan Li, Dujian Li, Jie Gu, Duocheng Qian, Xiaojing Qin, Yu Chen
Summary: The study found that exosomal PSGR promoted migration, invasion, stemness, and epithelial-mesenchymal transitions of prostate cancer cells, and reshaped the mRNA profiles of the cells.
Article
Oncology
Xuewu You, Ying Wang, Jinyu Meng, Sai Han, Lu Liu, Yu Sun, Junhua Zhang, Shuqin Sun, Xinyue Li, Wenxiong Sun, Yajie Dong, Youzhong Zhang
Summary: This study revealed that TGF-beta 1 stimulates cervical cancer cells to release exosomes containing miR-663b, which promotes metastasis. MiR-663b directly targets MGAT3 and is involved in the EMT process that affects cancer cell migration and invasion.
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Article
Biochemistry & Molecular Biology
Xiao Liu, Yu He, Yonghua Tong, Qiu Huang, Haojie Shang, Zhiqiang Chen, Kun Tang
Summary: PODNL1 has been identified as a potential therapeutic target and prognostic biomarker for bladder cancer (BLCA). Its high expression is associated with the clinical and pathological characteristics of BLCA, as well as poor prognosis. It plays a role in regulating the proliferation, migration, and epithelial mesenchymal transition (EMT) process of BLCA cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Feng Qiu, Qiuchen Liu, Yanfu Xia, Hengxi Jin, Yuxin Lin, Xiaojun Zhao
Summary: This study reveals the tumor-promoting role of circ_0000658 in bladder cancer and its regulation through the miR-498/HMGA2 axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Melodie Migault, Sunil Sapkota, Cameron P. Bracken
Summary: This review discusses the large number of regulators involved in epithelial-mesenchymal transition (EMT) and the implications for understanding EMT and the genetic machinery controlling complex biological processes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Reproductive Biology
Germano Aguiar Ferreira, Carolina Hassibe Thome, Clarice Izumi, Mariana Lopes Grassi, Guilherme Pauperio Lanfredi, Marcus Smolka, Vitor Marcel Faca, Francisco Jose Candido dos Reis
Summary: This study conducted a proteomic analysis of exosomes secreted by ovarian cancer cells undergoing epithelial-mesenchymal transition (EMT) to identify potential biomarkers for ovarian cancer classification. Differential regulation of proteins in exosomes after EMT induction was observed, and PLAU, LAMB1, COL6A1, and TGFB1 were identified as potential biomarkers for the mesenchymal high-grade serous ovarian cancer (HGSOC) subtype.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Cell Biology
Ying Xiang, Dong Lv, Tao Song, Chao Niu, Ying Wang
Summary: This study reveals that miR-139-5p carried by BMSCs-EVs inhibits bladder cancer cell malignancy by targeting KIF3A and activating p21. It also shows that miR-139-5p in BMSCs-EVs can arrest tumor formation and lung metastasis of bladder cancer cells in vivo.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, Satoshi Kataoka, Hirotaka Furuke, Wataru Takaki, Jun Kiuchi, Hiroki Shimizu, Yusuke Yamamoto, Shuhei Komatsu, Atsushi Shiozaki, Yoshiaki Kuriu, Eigo Otsuji
Summary: In this study, miR-4442 was identified as a potential biomarker for predicting early recurrence in colorectal cancer. The level of miR-4442 was associated with the risk of recurrence and increased with earlier recurrence dates. Furthermore, miR-4442 played a role in promoting the proliferative, migratory, and invasive activities of colorectal cancer cells by directly targeting the messenger RNA of RBMS1, thus regulating epithelial-mesenchymal transition (EMT) in colorectal cancer.