Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

(2019) D. B. Lipsett et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction

(2018) Tsutomu Nakada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors

(2018) Isuru Jayasinghe et al.   Cell Reports

Cardiac CaV1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

(2018) Lin Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator

(2018) Ang Guo et al.   SCIENCE

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart FailureNovelty and Significance

(2016) Jose L. Sanchez-Alonso et al.   CIRCULATION RESEARCH

JPH-2 interacts with Cai-handling proteins and ion channels in dyads: Contribution to premature ventricular contraction–induced cardiomyopathy

(2016) Min Jiang et al.   HEART RHYTHM

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release

(2016) Julia O. Reynolds et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes

(2016) Michelle L. Munro et al.   JOURNAL OF CELL SCIENCE

Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes

(2016) Yanqi Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+ microdomains organized by junctophilins

(2015) Hiroshi Takeshima et al.   CELL CALCIUM

Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial MyocytesCLINICAL PERSPECTIVE

(2015) Alexey V. Glukhov et al.   CIRCULATION

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

(2015) Ang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

(2014) Caimei Zhang et al.   CIRCULATION

Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes

(2014) Simon Bryant et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress

(2014) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calpain‐Dependent Cleavage of Junctophilin‐2 and T‐Tubule Remodeling in a Mouse Model of Reversible Heart Failure

(2014) Chia‐Yen C. Wu et al.   Journal of the American Heart Association

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

(2013) Hayley J. Bennett et al.   BIOCHEMICAL JOURNAL

Nanoscale Distribution of Ryanodine Receptors and Caveolin-3 in Mouse Ventricular Myocytes: Dilation of T-Tubules near Junctions

(2013) Joseph Wong et al.   BIOPHYSICAL JOURNAL

Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure

(2013) H.-B. Zhang et al.   CARDIOVASCULAR RESEARCH

Critical roles of junctophilin-2 in T-tubule and excitation–contraction coupling maturation during postnatal development

(2013) Biyi Chen et al.   CARDIOVASCULAR RESEARCH

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development

(2013) Julia O. Reynolds et al.   CARDIOVASCULAR RESEARCH

In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice

(2013) Rong-Chang Li et al.   CIRCULATION RESEARCH

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling

(2013) Peter T. Wright et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization

(2013) David L. Beavers et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nanoscale-Targeted Patch-Clamp Recordings of Functional Presynaptic Ion Channels

(2013) Pavel Novak et al.   NEURON

Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells

(2012) Hao-Di Wu et al.   CARDIOVASCULAR RESEARCH

Mir-24 Regulates Junctophilin-2 Expression in Cardiomyocytes

(2012) Ming Xu et al.   CIRCULATION RESEARCH

β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction

(2012) Biyi Chen et al.   FASEB JOURNAL

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

(2011) Ralph J. van Oort et al.   CIRCULATION

Junctophilin-2 Expression Silencing Causes Cardiocyte Hypertrophy and Abnormal Intracellular Calcium-Handling

(2011) Andrew P. Landstrom et al.   Circulation-Heart Failure

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

(2011) Lucia Golini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology

(2011) Robert D. Harvey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

(2010) Sheng Wei et al.   CIRCULATION RESEARCH

Palmitoylation regulates raft affinity for the majority of integral raft proteins

(2010) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of T-Tubules and Reduced Synchrony of Ca 2+ Release in Myocytes From Chronically Ischemic Myocardium

(2007) Frank R. Heinzel et al.   CIRCULATION RESEARCH