Article
Polymer Science
Fanni Falusi, Szilvia Berko, Anita Kovacs, Maria Budai-Szucs
Summary: Foams are becoming increasingly popular in dermatology due to their advantages in terms of easy spreading, good skin sensation, and applicability in special skin conditions. This study aimed to improve the stability of dermal foams by using different hydrogel-forming polymers. The combination of xanthan gum and dexpanthenol was found to be ideal for both foam formation and stability.
Article
Chemistry, Applied
Lei Zhao, Fei Pan, Arshad Mehmood, Huimin Zhang, Ashfaq Ur Rehman, Jiayi Li, Shuai Hao, Chengtao Wang
Summary: The combined use of rosmarinic acid and xanthan gum was found to significantly enhance the stability of anthocyanins, primarily through intermolecular interactions such as hydrogen bonding and van der Waals forces. Xanthan gum exhibited stronger binding interactions with anthocyanins in the ternary complexes compared to rosmarinic acid. This study provides valuable insights into enhancing the stability of anthocyanins in the presence of ascorbic acid.
Article
Chemistry, Applied
Daisa Hakbart Bonemann, Alexander Ossanes de Souza, Camila Correa Pereira, Eliezer Quadro Oreste, Anderson Schwingel Ribeiro, Mariana Antunes Vieira
Summary: This study describes a sample preparation method using acid decomposition in a reflux system for the determination of Hg on xanthan gum samples by cold vapor atomic absorption spectrometry. The optimized conditions proved to be safe and efficient for the quantification of Hg with excellent recoveries. The method is suitable for the wide applicability of xanthan gum in various products.
FOOD HYDROCOLLOIDS
(2021)
Review
Polymer Science
Masrina Mohd Nadzir, Retno Wahyu Nurhayati, Farhana Nazira Idris, Minh Hong Nguyen
Summary: Bacterial exopolysaccharides (EPSs) are important compounds secreted by bacteria, with a wide range of biomedical applications. The diverse properties of different types of EPSs allow for various controlled applications in the field of biomedicine.
Article
Engineering, Environmental
Nivedha Panneerselvam, Devikala Sundaramurthy, Arthanareeswari Maruthapillai
Summary: In this study, biopolymers-based nanocomposite films containing ascorbic acid were prepared for food packaging applications. The addition of CuO@Ascorbic acid significantly improved the mechanical performance of the films and enhanced their antibacterial and antioxidant activities. Among the different films, the Xanthan gum-incorporated CuO@Ascorbic acid showed the strongest antibacterial and antioxidant activities, making it a potential candidate for biological food packaging.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Emilia Szymanska, Joanna Potas, Marcin Baranowski, Robert Czarnomysy, Magdalena Ewa Sulewska, Anna Basa, Malgorzata Pietruska, Krzysztof Bielawski, Katarzyna Winnicka
Summary: Emulgels composed of natural polysaccharide gums (tragacanth, xanthan, and gellan) were evaluated as oromucosal platforms of delta-aminolevulinic acid (ALA) for photodynamic therapy (PDT). These emulgels demonstrated superior mucoadhesiveness and textural properties compared to commercial oromucosal gels. Furthermore, they promoted the absorption rate of ALA and enhanced photosensitizer retention in the buccal epithelium.
Article
Chemistry, Physical
E. R. Mertcan, Nermin Orakdogen
Summary: Natural polymer-based cryogenically structured hybrid gels as support matrices were prepared by constructing synergistic multiple interactions among copolymer poly(2-hydroxyethyl methacrylate-co-glycidyl methacrylate) and different polysaccharides. The addition of CMC and MDex significantly improved the thermal stability of the gels. Hybrid cryogels exhibited higher swelling than hybrid hydrogels, with HyA-doped hybrid cryogels showing the highest swelling. A solvent selection methodology based on solvent/polymer interaction was presented. This study provides insights into the design of cryogenically structured hybrid materials for water purification.
Article
Chemistry, Multidisciplinary
Nafisur Rahman, Abdur Raheem
Summary: A Fe (III)-tartaric acid/xanthan gum/graphene oxide/polyacrylamide (FXM) hydrogel was synthesized and its effectiveness in removing levofloxacin from water was investigated. The FXM hydrogel exhibited high adsorption capacity and controllable properties.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Preaploy Hong-in, Wantida Chaiyana
Summary: This study evaluated the biological activities of black Dimocarpus longan Lour. seed extracts and successfully developed a lamellar liquid crystal (LLC) formulation. The ethyl acetate extract exhibited the strongest inhibitory activities against matrix metalloproteinase-1 and hyaluronidase. Gallic acid was identified as the main compound responsible for the biological activities of the extract. The LLC formulation containing the extract showed good stability and crystallinity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Emilia Szymanska, Joanna Potas, Mateusz Maciejczyk, Magdalena Ewa Sulewska, Malgorzata Pietruska, Anna Zalewska, Aleksandra Pietruska, Katarzyna Winnicka
Summary: This study tested different emulgel compositions for the delivery of delta-aminolevulinic acid and investigated the impact of the drug on the behavior of gelling agents. The results showed that a combination of xanthan and gellan gum enhanced the retention of the emulgels in oral mucosal tissue. In addition, the incorporation of delta-aminolevulinic acid promoted interactions with mucosal tissue. Cytotoxicity studies demonstrated that emulgels based on tragacanth and gellan/xanthan may have a protective effect on the metabolic activity of human gingival fibroblasts and keratinocytes.
Article
Multidisciplinary Sciences
Seyyed Vahid Niknezhad, Sedigheh Kianpour, Sina Jafarzadeh, Mohsen Alishahi, Ghasem Najafpour Darzi, Mohammad Hossein Morowvat, Younes Ghasemi, Amin Shavandi
Summary: In this study, Pantoea sp. BCCS 001 GH bacterium was used to produce an exopolysaccharide (EPS) called Pantoan using sugar beet molasses as a carbon source. The kinetics and optimization of Pantoan biosynthesis were investigated, and the effects of four factors on Pantoan concentration were evaluated. The functional groups and properties of the produced Pantoan were characterized. This study provides guidance for the design and optimization of Pantoea sp. BCCS 001 GH culture media for the production of valuable EPS.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Hasan Ghasemzadeh, Aida Mehrpajouh, Malihe Pishvaei
Summary: This study investigates the effects of various additives commonly used in acrylic polymers on the compressive strength of clayey soil. The results show that thickeners, wetting agents, and pH control agents significantly influence the soil mechanical behavior.
Article
Chemistry, Multidisciplinary
Vivek Puri, Ameya Sharma, Pradeep Kumar, Inderbir Singh, Kampanart Huanbutta
Summary: The research aimed to synthesize and characterize a novel mucoadhesive carbohydrate polymer for formulating mucoadhesive tablets of domperidone, demonstrating potential applications in drug delivery systems.
Article
Polymer Science
Fahad Pervaiz, Wajeeha Tanveer, Hina Shoukat, Sadia Rehman
Summary: The present study developed a polyethylene glycol and xanthan-gum based interpenetrating network for controlled drug release. The network, synthesized via copolymerization of natural and synthetic polymers, showed potential for drug release control according to various characterization and analysis techniques.
Article
Multidisciplinary Sciences
Teck Wei Lim, Renee Lay Hong Lim, Liew Phing Pui, Chin Ping Tan, Chun Wai Ho
Summary: This study aimed to improve the stability of betacyanins in red dragon fruit drink by optimizing fermentation and adding citric acid. The results showed that the hydrocolloid mixture of xanthan gum and carboxymethyl cellulose significantly increased the viscosity and Brix degrees of the samples, while citric acid reduced the pH. The fermented red dragon fruit drink with betacyanins stabilized by the 3E formulation can be produced as an independent functional drink or used as a stable, functional ingredient (natural colorant) in the food industry.
Review
Food Science & Technology
Manuela Machado, Luis M. Rodriguez-Alcala, Ana M. Gomes, Manuela Pintado
Summary: Vegetable oils are crucial in the human diet, but processing can lead to oxidation and negative effects on quality. Strategies such as antioxidants and encapsulation techniques can improve oil stability.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Teresa Bonifacio-Lopes, Luis M. G. Castro, Ana Vilas-Boas, Debora Campos, Jose A. Teixeira, Manuela Pintado
Summary: Two methods of extracting bioactive compounds from brewer's spent grain were used, and their antioxidant activity, total phenolic content, and polyphenol profile were measured. The extraction using 60% ethanol:water showed higher antioxidant activity and total phenolic content, while the extraction using 80% ethanol:water had higher bioaccessibility index for polyphenols. All the extracts demonstrated potential prebiotic activity by enhancing the growth of probiotic microorganisms.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Sofia F. Reis, Pedro A. R. Fernandes, Vitor J. Martins, Sara Goncalves, Luis P. Ferreira, Vitor M. Gaspar, Diogo Figueira, Diogo Castelo-Branco, Joao F. Mano, Manuel A. Coimbra, Elisabete Coelho
Summary: This study aims to validate the use of extracted BSY mannoproteins as a clean label and vegan source of ingredients to replace food additives and protein from animal sources. The emulsifying properties and structure/function relationships of polysaccharides with different structural features extracted from BSY were investigated. The alkaline extraction mainly solubilized highly branched mannoproteins and glycogen, while the subcritical water extraction solubilized mannoproteins with short mannan chains and (1 -> 4)- and (beta 1 -> 3)-linked glucans. Beta-glucans and O-linked mannoproteins contributed to emulsion stability by preventing Ostwald ripening.
Article
Biochemistry & Molecular Biology
Paulo Nova, Ana Pimenta-Martins, Elia Maricato, Claudia Nunes, Helena Abreu, Manuel A. Coimbra, Ana Cristina Freitas, Ana Maria Gomes
Summary: The chemical composition and antioxidant profile of five edible macroalgae were determined in this study. The tested seaweeds showed considerable amounts of proteins, carbohydrates, fats, and various minerals. The polysaccharide composition varied among the different seaweed species, with Fucus vesiculosus standing out for its high fucoidan content and strong antioxidant activity. These marine macroalgae have great potential for use in health, food, and industrial applications.
Review
Nutrition & Dietetics
Helena R. Rocha, Marta C. Coelho, Ana M. Gomes, Manuela E. Pintado
Summary: Numerous epidemiologic studies have shown that the consumption of fruits and vegetables can decrease the risk of various chronic diseases. The positive health benefits are attributed to secondary plant metabolites, particularly carotenoids and their metabolites, which affect gene expression and protein translation. However, there is still a lack of research on the digestive processes, stability, functionality, and impact on gut microbiota of carotenoids, as well as their role in oxidative stress and inflammatory pathways. Future studies should focus on understanding the relationships between carotenoids, related metabolites, and their effects on transcription factors and metabolism.
Article
Chemistry, Multidisciplinary
Manuela Machado, Luis M. Rodriguez-Alcala, Ana Maria Gomes, Manuela Pintado
Summary: Bioactive lipids, such as medium-chain fatty acids, have important health benefits. This study aimed to enhance the quality and gastrointestinal resistance of vegetable oil-functionalized yogurts and investigate their potential health effects. Fortification with coconut and avocado vegetable oils improved the nutritional value of the yogurts, particularly those with vegetable oil bigels. Despite the poor stability and bioavailability of bioactive fatty acids, the fortified yogurts showed reduced lipid accumulation in cells and improved secretion of adiponectin, a hormone associated with metabolism regulation. They also demonstrated anti-inflammatory effects. These findings suggest that fortifying yogurt with vegetable oils could be a viable strategy for managing obesity.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Rita S. Inacio, Luis M. Rodriguez-Alcala, Ligia L. Pimentel, Jorge A. Saraiva, Ana M. P. Gomes
Summary: High-pressure processing (HPP) can be used to pasteurize raw ewes' milk Serra da Estrela cheese without affecting its lipid composition, ensuring both microbial safety and quality during storage. The total triglycerides content and the fatty acid profiles remained similar between HPP-treated and control cheeses over the course of 15 months of refrigerated storage. HPP-treated Serra da Estrela cheese exhibited a high content of conjugated linoleic acid, comparable to the control cheese, with similar atherogenic and thrombogenic indices.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Rita S. Inacio, Maria J. P. Monteiro, Jose A. Lopes-da-Silva, Ana M. P. Gomes, Jorge A. Saraiva
Summary: This study compared the effects of non-vacuum greaseproof paper wrapping and vacuum packaging in plastic film on Serra da Estrela cheese. The results showed that there were no significant differences in the counts of lactococci, lactobacilli, enterococci, and total mesophiles between the two packaging systems. Yeasts and molds were present in higher numbers in non-vacuum paper-wrapped cheeses. Vacuum packaging allowed for better control of cheese proteolysis and resulted in a harder texture compared to non-vacuum paper-wrapped cheeses. Overall, non-vacuum paper wrapping is suitable for short-term storage, while vacuum packaging in plastic film is preferable for long-term storage.
Article
Food Science & Technology
Joana R. Costa, Maria J. Pereira, Silvia S. Pedrosa, Beatriz Gullon, Nelson M. de Carvalho, Manuela E. Pintado, Ana Raquel Madureira
Summary: This study optimized a two-step alkaline extraction method for arabinoxylans from sugarcane straw and evaluated its industrial-scale production potential. The arabinoxylans extracted from the straw had high purity levels and an average molecular weight of 231 kDa, with an estimated production cost of 0.239 euro/g arabinoxylan. This work provides a model for industrial-scale production of arabinoxylans.
Article
Biotechnology & Applied Microbiology
Sergio Sousa, Ana P. Carvalho, Carlos A. Pinto, Renata A. Amaral, Jorge A. Saraiva, Ricardo N. Pereira, Antonio A. Vicente, Ana C. Freitas, Ana M. Gomes
Summary: To make Nannochloropsis oculata a financially viable source for commercial applications, extraction efficiency needs to be improved. This study tested emerging technologies such as high hydrostatic pressure (HHP) and moderate electric fields (MEF), along with solvents with different polarity indexes, to increase accessibility and extraction yields of eicosapentaenoic acid (EPA). The combined use of HHP and MEF resulted in a 62% increase in EPA extraction yields from wet N. oculata biomass. These findings are highly relevant for the food and pharmaceutical industries, providing alternatives to traditional extraction methods with increased yields and reduced environmental impact.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Manuela Machado, Luis M. Rodriguez-Alcala, Manuela Pintado, Ana Maria Gomes
Summary: The purpose of this study was to evaluate the effects of coconut oil on lipid metabolism-related diseases and immune response using in vitro models. Coconut oil doses were selected based on safety evaluations performed through genotoxicity and cytotoxicity tests. The results showed that coconut oil, mainly composed of medium-chain fatty acids, exhibited a high antioxidant capacity. It was capable of reducing lipid accumulation in hepatocytes and adipocytes, and modulating the immune response by reducing the secretion of pro-inflammatory cytokines.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Margarida Faustino, Sara Silva, Eduardo M. Costa, Ana Margarida Pereira, Joana Odila Pereira, Ana Sofia Oliveira, Carlos M. H. Ferreira, Carla F. Pereira, Joana Durao, Manuela E. Pintado, Ana P. Carvalho
Summary: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli remain a common public health problem. Long-acting prophylactic antibiotics are commonly used in the treatment of chronic UTIs, but they contribute to the development of antibiotic-resistant strains. D-mannose and mannose oligosaccharides (MOS) have the potential to serve as alternatives to antibiotic prophylaxis due to their ability to inhibit bacterial adhesion and infection. However, research on the effect of MOS in UTIs is limited. Preliminary results suggest that MOS extracts have the potential to be used in UTIs management by competitively inhibiting bacterial adhesion through mannose action.
Review
Fisheries
Marta Fernandez Cunha, Ezequiel R. Coscueta, Maria Emilia Brassesco, Frederico Almada, David Goncalves, Manuela Pintado
Summary: The aquatic environment holds a vast source of bioactive molecules, with fish epidermal mucus being a promising source. However, the study of fish mucus is still relatively unexplored, and there is a need for optimization of collection and study methods. This review discusses different methods of mucus collection and evaluates their effectiveness.
REVIEWS IN FISHERIES SCIENCE & AQUACULTURE
(2023)
Article
Green & Sustainable Science & Technology
Pedro Rodrigues Ribeiro, Patricia Batista, Francisco Mendes-Palma, Manuela Pintado, Patricia Oliveira-Silva
Summary: This study examines consumer knowledge and involvement in sustainability goals, revealing that consumers prioritize budget, quality, comfort, and functionality over sustainability when purchasing textiles. They are cautious about clothing rental or sharing, but willing to extend product lifespans and are concerned about responsible disposal. They value the social and informational attributes of textile products and demand brand transparency.
Article
Chemistry, Applied
Ana Luiza Fontes, Bruna Neves, Tiago Conde, Daniela Couto, Ligia Leao Pimentel, Luis Miguel Rodriguez-Alcala, M. Rosario Domingues, Ana Maria Gomes
Summary: This study investigated potential fatty acid byproducts during microbial enrichment of CLA/CLNA and found that no additional side-fatty acid metabolites were released except for stearic acid in the presence of linoleic acid.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)