Protease‐activated receptor‐2 accelerates intestinal tumor formation through activation of nuclear factor‐κB signaling and tumor angiogenesis in Apc Min/+ mice

Membrane-Anchored Serine Proteases and Protease-Activated Receptor-2–Mediated Signaling: Co-Conspirators in Cancer Progression

(2019) Nisha R. Pawar et al.   CANCER RESEARCH

Cell surface–anchored serine proteases in cancer progression and metastasis

(2019) Carly E. Martin et al.   CANCER AND METASTASIS REVIEWS

Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy

(2019) Roman Szabo et al.   DEVELOPMENT

Matrix metalloproteinase-2: A key regulator in coagulation proteases mediated human breast cancer progression through autocrine signaling

(2018) Kaushik Das et al.   BIOMEDICINE & PHARMACOTHERAPY

Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas

(2018) Tsuyoshi Fukushima et al.   CANCER SCIENCE

Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): Emerging key players in epithelial integrity and cancer

(2018) Hiroaki Kataoka et al.   PATHOLOGY INTERNATIONAL

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

(2017) Hendrik Ungefroren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis

(2016) Olivier Bardou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling

(2016) S. M. Le Gall et al.   BLOOD

The role of type II transmembrane serine protease-mediated signaling in cancer

(2016) Lauren M. Tanabe et al.   FEBS Journal

Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2

(2016) Ai Kanemaru et al.   INTERNATIONAL JOURNAL OF CANCER

Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma

(2016) Jeff J. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model

(2016) Makiko Kawaguchi et al.   Oncotarget

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

Proteolytic Activation of the Protease-activated Receptor (PAR)-2 by the Glycosylphosphatidylinositol-anchored Serine Protease Testisin

(2014) Kathryn H. Driesbaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line

(2014) YING WU et al.   Molecular Medicine Reports

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

(2014) K U Sales et al.   ONCOGENE

Protease Activated Receptor-2 Expression and Function in Asthmatic Bronchial Smooth Muscle

(2014) Benoit Allard et al.   PLoS One

Regulation of Feto-Maternal Barrier by Matriptase- and PAR-2-Mediated Signaling Is Required for Placental Morphogenesis and Mouse Embryonic Survival

(2014) Roman Szabo et al.   PLoS Genetics

Human airway trypsin-like protease induces mucin5AC hypersecretion via a protease-activated receptor 2-mediated pathway in human airway epithelial cells

(2013) Chunyi Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Suppressor of Intestinal Tumorigenesis

(2013) S. Hoshiko et al.   CANCER RESEARCH

Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model

(2013) Jingjia Ye et al.   CANCER SCIENCE

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

(2013) Frank Gieseler et al.   Cell Communication and Signaling

MicroRNA-34a Mediates the Autocrine Signaling of PAR2-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation

(2013) Yiming Ma et al.   PLoS One

TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620

(2013) Lichao Hu et al.   TUMOR BIOLOGY

Kallikrein-Related Peptidase 14 Acts on Proteinase-Activated Receptor 2 to Induce Signaling Pathway in Colon Cancer Cells

(2011) Valérie Gratio et al.   AMERICAN JOURNAL OF PATHOLOGY

Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity

(2011) Makiko Kawaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors

(2011) Hyunjae Chung et al.   BIOLOGICAL CHEMISTRY

Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell

(2011) Zhi-Chao Jia et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis

(2011) P Kosa et al.   ONCOGENE

Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620

(2011) Donglin Guo et al.   TUMOR BIOLOGY

Local Protease Signaling Contributes to Neural Tube Closure in the Mouse Embryo

(2010) Eric Camerer et al.   DEVELOPMENTAL CELL

Type II Transmembrane Serine Protease (TTSP) deregulation in cancer

(2010) Siobhan et al.   Frontiers in Bioscience-Landmark

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

(2010) Andrea Pia Elste et al.   JOURNAL OF MOLECULAR HISTOLOGY

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

(2010) Katiuchia Uzzun Sales et al.   NATURE GENETICS

Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)

(2009) Tomomitsu Tahara et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Role of Tissue Factor in Cancer

(2009) Raj S. Kasthuri et al.   JOURNAL OF CLINICAL ONCOLOGY

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE