Phosphoglycerate dehydrogenase promotes proliferation and bortezomib resistance through increasing reduced glutathione synthesis in multiple myeloma

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E

(2019) Xuhui Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Serine Metabolism Supports Macrophage IL-1β Production

(2019) Arianne E. Rodriguez et al.   Cell Metabolism

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas

(2017) Ming Wu et al.   OncoTargets and Therapy

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

(2017) Boxi Zhang et al.   Cell Reports

NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells

(2016) Cheng Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myeloma

(2016) Y Qin et al.   LEUKEMIA

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

(2016) G P Soriano et al.   LEUKEMIA

Comprehensive Identification of RNA-Binding Domains in Human Cells

(2016) Alfredo Castello et al.   MOLECULAR CELL

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells

(2016) K K Starheim et al.   Blood Cancer Journal

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma

(2015) P. Maiso et al.   CANCER RESEARCH

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth

(2015) Florence Polet et al.   Oncotarget

Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway

(2014) Rocio Acuna-Hidalgo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death

(2014) L. Yin et al.   BLOOD

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

(2014) Yang Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers

(2013) Wen Zhou et al.   CANCER CELL

Serine Metabolism: Some Tumors Take the Road Less Traveled

(2013) Ralph J. DeBerardinis   Cell Metabolism

Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer

(2013) Binbin Tan et al.   JOURNAL OF PROTEOME RESEARCH

ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma

(2013) W Zhou et al.   LEUKEMIA

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Agents for Multiple Myeloma to Overcome Resistance in Phase III Clinical Trials

(2013) Robert Z. Orlowski   SEMINARS IN ONCOLOGY

Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

(2013) Zaynab Al-Eisawi et al.   Journal of Ovarian Research

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Serum Metabolic Signatures of Fulminant Type 1 Diabetes

(2012) Jingyi Lu et al.   JOURNAL OF PROTEOME RESEARCH

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

(2010) Sirkku Pollari et al.   BREAST CANCER RESEARCH AND TREATMENT

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

(2009) Hongjuan Dong et al.   LEUKEMIA & LYMPHOMA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Multiple myeloma

(2008) R. A. Kyle et al.   BLOOD