Article
Rehabilitation
Nurten Gizem Tore, Deran Oskay, Aslihan Avanoglu Guler, Abdurrahman Tufan
Summary: The aim of this study was to translate and culturally adapt the CSF-17 into Turkish and investigate its reliability and convergent validity in Turkish-speaking patients with SSc. The results showed that the Turkish version of CSF-17 has good reliability and convergent validity, making it a reliable and valid tool for Turkish-speaking SSc patients.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Review
Medicine, General & Internal
Laura Ross, Elizabeth Paratz, Murray Baron, Andre La Gerche, Mandana Nikpour
Summary: Cardiac disease in systemic sclerosis (SSc) is a leading cause of death, with sudden cardiac death (SCD) occurring more commonly in SSc patients. Diffuse myocardial fibrosis, myocarditis, and ischemic heart disease are prevalent in SSc and contribute to the increased risk of SCD. Further research is needed to understand the specific risk factors for SCD in SSc and identify opportunities for primary prevention.
Review
Medicine, General & Internal
Kholoud Almaabdi, Zareen Ahmad, Sindhu R. Johnson
Summary: Systemic sclerosis is an autoimmune disease characterized by immune abnormalities, vasculopathy, and fibrosis. Autoantibody testing, including ANA, anti-Scl-70, and anticentromere antibodies, has become increasingly important for diagnosis and prognostication. This review examines the epidemiology, clinical associations, and prognostic value of advanced autoantibody testing in systemic sclerosis.
Article
Rheumatology
Mike O. Becker, Rucsandra Dobrota, Alexandru Garaiman, Rudolf Debelak, Kim Fligelstone, Ann Tyrrell Kennedy, Annelise Roennow, Yannick Allanore, Patricia E. Carreira, Laszlo Czirjak, Christopher P. Denton, Roger Hesselstrand, Gunnel Sandqvist, Otylia Kowal-Bielecka, Cosimo Bruni, Marco Matucci-Cerinic, Carina Mihai, Ana Maria Gheorghiu, Ulf Mueller-Ladner, Joseph Sexton, Tore K. Kvien, Turid Heiberg, Oliver Distler
Summary: The EULAR ScleroID, developed and validated with input from patient experts, is a novel, brief, disease-specific, patient-derived PROM for systemic sclerosis (SSc), suitable for research and clinical use. It showed strong correlation and reliability compared to existing comparators, with excellent sensitivity to change.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Patrick Coit, Kaila L. Schollaert, Emily M. Mirizio, Kathryn S. Torok, Amr H. Sawalha
Summary: The study assessed DNA methylation differences between juvenile systemic sclerosis (jSSc) and juvenile localized scleroderma (jLS), revealing distinct epigenetic patterns and unique methylated genes in both diseases. Compared to healthy controls, differential methylation sites and genes were identified in jSSc and jLS, indicating potential novel diagnostic biomarkers for localized scleroderma. Pathway analysis showed enrichment of inflammatory pathways in jSSc and the HIPPO signaling pathway in jLS, highlighting different biological processes involved in each condition.
CLINICAL IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Mahmoud Nassar, Victoria Ghernautan, Nso Nso, Akwe Nyabera, Francisco Cuevas Castillo, Wan Tu, Luis Medina, Camelia Ciobanu, Mostafa Alfishawy, Vincent Rizzo, Saphwat Eskaros, Mamdouh Mahdi, Mohamed Khalifa, Mohamed El-Kassas
Summary: The gastrointestinal tract is frequently affected in individuals with systemic/localized scleroderma, leading to various GI manifestations and complications. Females are more susceptible to developing scleroderma, and esophageal and intestinal symptoms are common. Abnormal bowel movement and bacterial overgrowth contribute to malabsorption and increased mortality rate. Fecal incontinence is a common symptom that can lead to depression.
Article
Rheumatology
Robyn T. Domsic, Shiyao Gao, Maureen Laffoon, Steven Wisniewski, Yuqing Zhang, Virginia Steen, Robert Lafyatis, Thomas A. Medsger
Summary: Regardless of whether the first SSc manifestation or first non-Raynaud manifestation is used to define disease onset, a disease duration of less than 18 months at enrollment is preferable. A longer disease duration criterion more frequently results in regression to the mean of the mRSS score, which likely contributes to negative trial outcomes.
Review
Health Care Sciences & Services
Francesco Reggiani, Gabriella Moroni, Claudio Ponticelli
Summary: Systemic sclerosis is a chronic autoimmune disease that often involves the kidneys. Scleroderma renal crisis is the most serious renal event associated with this condition, and early and aggressive treatment is necessary to prevent irreversible organ damage and death.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Rheumatology
Burcu Ayoglu, Michele Donato, Daniel E. Furst, Leslie J. Crofford, Ellen Goldmuntz, Lynette Keyes-Elstein, Judith James, Susan Macwana, Maureen D. Mayes, Peter McSweeney, Richard A. Nash, Keith M. Sullivan, Beverly Welch, Ashley Pinckney, Rong Mao, Lorinda Chung, Purvesh Khatri, Paul J. Utz
Summary: Results from the SCOT clinical trial showed that HSCT had significant benefits over CTX in patients with systemic sclerosis. The objective of this study was to test the hypothesis that transplantation stabilizes the autoantibody repertoire in patients with favorable clinical outcomes. Analysis of autoantibody profiles revealed significant differences between HSCT and CTX-treated patients, suggesting that HSCT alters the autoantibody repertoire while CTX treatment does not.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Fatemeh Vafashoar, Kazem Mousavizadeh, Hadi Poormoghim, Amir Haghighi, Salar Pashangzadeh, Nazanin Mojtabavi
Summary: The study found that progesterone treatment increased collagen content in fibrotic and normal lung tissues, as well as increased alpha-SMA and TGF-beta in fibrotic lung tissues while decreasing MMP9. Furthermore, progesterone treatment also decreased the gene expression of Col1a2, Ctgf, and End1 in bleomycin-injured lung tissues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Serena Fineschi
Summary: COVID-19 infection can trigger autoimmune diseases like systemic sclerosis (SSc) and lead to the production of autoantibodies. This case report describes a patient who developed autoantibody production and symptoms affecting the skin and gastrointestinal system after mild COVID-19 infection, eventually being diagnosed with SSc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Summary: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by excessive extracellular matrix deposition. B cells play a fundamental role in the pathogenesis and development of SSc, as they infiltrate lesional sites and produce profibrotic cytokines. B cell counts are increased in SSc patients and show differences in various B cell compartments. B cell signaling is impaired in SSc patients, and B cell depletion therapy has shown therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Rheumatology
Michael Hughes, Bashar Kahaleh, Christopher P. Denton, Justin C. Mason, Marco Matucci-Cerinic
Summary: In patients with SSc, the presence of SSc-AAV is associated with a severe disease course, typically presenting with features of microscopic polyangiitis or renal-limited vasculitis. The interaction between SSc and AAV exacerbates vascular disease, with similar patterns of major organ involvement. Current management strategies are based on treating SSc-AAV similar to isolated AAV, highlighting the need for further investigation and therapeutic strategies specific to this rare clinical entity.
Review
Cardiac & Cardiovascular Systems
Peter Glynn, Sarah Hale, Tasmeen Hussain, Benjamin H. Freed
Summary: Systemic sclerosis (SSc) is a complex connective tissue disease that can affect various structural components of the heart, often being clinically silent in early disease. A review of cardiac imaging modalities emphasizes the importance of early detection and treatment optimization in SSc patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sophie Alami, Lucile Hervouet, Serge Poiraudeau, Karine Briot, Christian Roux
Article
Medicine, General & Internal
Sophie Alami, Vincent Cottin, Luc Mouthon, Dominique Desjeux, Esther Quessette, Serge Poiraudeau, Olivier Sitbon
Article
Rheumatology
Mathilde Benhamou, Isabelle Boutron, Marie Dalichampt, Gabriel Baron, Sophie Alami, Francois Rannou, Philippe Ravaud, Serge Poiraudeau
ANNALS OF THE RHEUMATIC DISEASES
(2013)
Article
Orthopedics
Sophie Alami, Dominique Desjeux, Marie Martine Lefevre-Colau, Anne Sophie Boisgard, Eric Boccard, Francois Rannou, Serge Poiraudeau
BMC MUSCULOSKELETAL DISORDERS
(2011)
Article
Multidisciplinary Sciences
Sophie Alami, Isabelle Boutron, Dominique Desjeux, Monique Hirschhorn, Gwendoline Meric, Francois Rannou, Serge Poiraudeau
Article
Multidisciplinary Sciences
Mathilde Benhamou, Gabriel Baron, Marie Dalichampt, Isabelle Boutron, Sophie Alami, Francois Rannou, Philippe Ravaud, Serge Poiraudeau
Article
Rheumatology
Agathe Papelard, Camille Daste, Sophie Alami, Katherine Sanchez, Alexandra Roren, Francois Segretin, Marie-Martine Lefevre-Colau, Francois Rannou, Luc Mouthon, Serge Poiraudeau, Christelle Nguyen
Article
Medicine, General & Internal
Christelle Nguyen, Isabelle Boutron, Rafael Zegarra-Parodi, Gabriel Baron, Sophie Alami, Katherine Sanchez, Camille Daste, Margaux Boisson, Laurent Fabre, Peggy Krief, Guillaume Krief, Marie-Martine Lefevre-Colau, Francois Rannou
Summary: This study compared the efficacy of standard osteopathic manipulative treatment (OMT) with sham OMT in reducing low back pain (LBP) specific activity limitations in patients with nonspecific subacute or chronic LBP. Results showed that standard OMT had a small effect on reducing LBP-specific activity limitations compared to sham OMT, but the clinical relevance of this effect is questionable.
JAMA INTERNAL MEDICINE
(2021)
Article
Orthopedics
Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla, Serge Poiraudeau
BMC MUSCULOSKELETAL DISORDERS
(2017)
Article
Rehabilitation
S. Alami, C. Palazzo, S. Poiraudeau
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2015)