Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

Erythroferrone Regulates Bone Remodeling in β-Thalassemia

(2020) Melanie Castro-Mollo et al.   BLOOD

Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis

(2019) Nathan F. Denton et al.   INTERNATIONAL JOURNAL OF OBESITY

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Regulation of Hepcidin by Erythropoiesis: The Story So Far

(2016) Sant-Rayn Pasricha et al.   Annual Review of Nutrition

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Structural insights into BMP receptors: Specificity, activation and inhibition

(2016) David Yadin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Iron overload in non-transfusion-dependent thalassemia: association with genotype and clinical risk factors

(2016) Adisak Tantiworawit et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

Hepcidin is suppressed by erythropoiesis in hemoglobin E  -thalassemia and  -thalassemia trait

(2014) E. Jones et al.   BLOOD

Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice

(2014) Martina Pauk et al.   INTERNATIONAL ORTHOPAEDICS

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Engineering a Monomeric Fc Domain Modality byN-Glycosylation for the Half-life Extension of Biotherapeutics

(2013) Tetsuya Ishino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Treating Iron Overload

(2013) Clara Camaschella   NEW ENGLAND JOURNAL OF MEDICINE

 -Thalassemia Intermedia: A Clinical Perspective

(2013) K. M. Musallam et al.   Cold Spring Harbor Perspectives in Medicine

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Longitudinal changes in serum ferritin levels correlate with measures of hepatic stiffness in transfusion-independent patients with β-thalassemia intermedia

(2012) Khaled M. Musallam et al.   BLOOD CELLS MOLECULES AND DISEASES

How I treat thalassemia

(2011) E. A. Rachmilewitz et al.   BLOOD

Elevated liver iron concentration is a marker of increased morbidity in patients with   thalassemia intermedia

(2011) K. M. Musallam et al.   HAEMATOLOGICA

Anemia, Ineffective Erythropoiesis, and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia

(2010) Sara Gardenghi et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

(2009) William J. Finlay et al.   JOURNAL OF MOLECULAR BIOLOGY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD