Article
Oncology
Fa-Xiu Chen, Qin Wan, Qing-Ling Li, Jing Fang, Le Peng, Jian Hu
Summary: This study investigated the effects of substance P (SP) on doxorubicin-induced cardiomyocyte injury using in vitro and in vivo approaches. The results showed that SP reduced cardiomyocyte apoptosis, likely by promoting autophagy. These findings suggest that SP may be a potential therapeutic target for doxorubicin-induced heart failure.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Medicine, Research & Experimental
Toshihide Kashihara, Risa Mukai, Shin-ichi Oka, Peiyong Zhai, Yasuki Nakada, Zhi Yang, Wataru Mizushima, Tsutomu Nakahara, Junco S. Warren, Maha Abdellatif, Junichi Sadoshima
Summary: The heart utilizes multiple adaptive mechanisms to maintain pump function, with YAP playing a crucial role in inducing compensatory cardiac hypertrophy through promoting glycolysis and upregulating the GLUT1 gene. This leads to the accumulation of glycolytic metabolites and ultimately promotes cardiac hypertrophy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Plant Sciences
Kai Sun, Jiahui Luo, Xingzhi Jing, Wei Xiang, Jiachao Guo, Xudong Yao, Shuang Liang, Fengjing Guo, Tao Xu
Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.
Article
Biochemistry & Molecular Biology
Xiaozhi Huang, Jiayin Zhang, Wenyi Wang, Zhishan Huang, Peidong Han
Summary: In this study, the role of Vps4a in regulating myocardial autophagy was investigated. The results showed that Vps4a deletion blocked the autophagic flux, leading to the accumulation of degradation substances and compromised cardiac function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemistry & Molecular Biology
Wei Zhao, Yameng Cui, Lina Liu, Xiaoqian Qi, Jingwen Liu, Shiqing Ma, Xin Hu, Zheng Zhang, Yue Wang, Hongfa Li, Zuomin Wang, Zihao Liu, Jie Wu
Summary: After the online publication of this article, the authors identified errors in the images used for compiling Fig. 3c, 3g, and Supplementary Fig. 3g.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Christian Kuhn, Maja Menke, Frauke Senger, Claudia Mack, Franziska Dierck, Susanne Hille, Inga Schmidt, Gabriele Brunke, Pia Buenger, Nesrin Schmiedel, Rainer Will, Samuel Sossalla, Derk Frank, Thomas Eschenhagen, Lucie Carrier, Renate Luellmann-Rauch, Ashraf Yusuf Rangrez, Norbert Frey
Summary: The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Lack of FYCO1 affects autophagy induction after glucose deprivation, leading to impaired cardiac function. FYCO1 overexpression rescues cardiac dysfunction in response to biomechanical stress by inducing autophagy.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Pengcheng Xue, Yang Liu, Haifeng Wang, Junling Huang, Ming Luo
Summary: Cardiomyocyte apoptosis is a crucial mechanism in the development of heart failure (HF). This study investigates the underlying mechanisms of HF using bioinformatics and experimental validation. The findings suggest that miR-103-3p may function as a potential therapeutic biomarker for HF progression by targeting Hlf and influencing apoptosis and autophagy in myocardial cells.
Article
Biochemistry & Molecular Biology
Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai
Summary: Hyperoside has shown neuroprotective effects in rotenone-induced PD rat model and SH-SY5Y cell model by affecting autophagy pathways, providing potential therapeutic benefits for Parkinson's disease treatment.
NEUROCHEMICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Fangfang Zhu, Jie Gao, Fuling Zeng, Yuling Lai, Xiaofeng Ruan, Gaopi Deng
Summary: This study investigated the protective effects and mechanisms of hyperoside against cyclophosphamide-induced ovarian damage and reduced fertility. The results showed that hyperoside can diminish follicular depletion, prevent excessive hypoxia and autophagy activation, and increase follicular reserve, thereby improving fertility in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Changzhen Ren, Kaiqiang Sun, Yanda Zhang, Yangxi Hu, Bowen Hu, Jian Zhao, Zhiqing He, Ru Ding, Weizhong Wang, Chun Liang
Summary: In a mouse model, the SGLT2 inhibitor empagliflozin was found to protect against sunitinib-induced cardiac dysfunction by regulating cardiomyocyte autophagy through the AMPK-mTOR signaling pathway. These findings suggest that SGLT2 inhibitor therapy may be a potential cardioprotective approach for cardiovascular complications in patients undergoing sunitinib treatment, but clinical trials are needed to confirm these effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Anastasia Pavlovna Sklifasovskaya, Mikhail Blagonravov, Anna Ryabinina, Vyacheslav Goryachev, Sergey Syatkin, Sergey Chibisov, Karina Akhmetova, Daniil Prokofiev, Enzo Agostinelli
Summary: This review article examines the influence of heat shock proteins (HSPs) on protein quality control systems in cardiomyocytes and their role in regulated cell death. HSPs play a dual role in apoptotic cascade, acting both as pro-apoptotic and anti-apoptotic factors depending on their cellular location. Additionally, the article discusses how autophagy can lead to cell death or serve as a cell survival mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Editorial Material
Cell Biology
Lea Montegut, Adrien Joseph, Hui Chena, Mahmoud Abdellatif, Christoph Ruckenstuhlg, Isabelle Martins, Frank Madeo, Guido Kroemer
Summary: DBI/ACBP is a conserved paracrine inhibitor that regulates autophagy and lifespan. Its increased levels in humans are associated with biological age and cardiovascular disease risk factors. Studies have shown that neutralizing DBI/ACBP can alleviate cardiac aging. Therefore, it may serve as a potential target for treating age-associated cardiovascular diseases.
Article
Plant Sciences
Yongkang Yang, Jing Li, Tingcai Rao, Zhirui Fang, Junyan Zhang
Summary: Hyperoside extracted from Hypericum perforatum and Crataegus pinnatifida has a protective effect on heart injury, improving cardiac function, reducing myocardial hypertrophy, and suppressing inflammation through regulating the autophagy pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Naqi Lian, Jing Tong, Weijie Zhu, Qinghai Meng, Miao Jiang, Mianli Bian, Yu Li
Summary: Preventing or treating heart failure by blocking cardiomyocyte apoptosis is effective, and autophagy is commonly observed in failed hearts. This study investigates the potential protective effect of ligustrazine and its derivative liguzinediol on regulating doxorubicin-induced cardiomyocyte apoptosis and explores the use of H9C2 cell line for identifying novel treatments for HF. The results showed that ligustrazine promotes autophagy and inhibits apoptosis of cardiomyocytes, reversing myocardial infarction remodelling. It suggests that ligustrazine and liguzinediol can be promising agents and autophagy is a potential pathway in the management of HF.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yun Gao, Xiaoye Fan, Wenjing Gu, Xinxin Ci, Liping Peng
Summary: The study demonstrates that Hyp protects against PMs-induced lung injury by regulating autophagy and apoptosis through the AMPK/mTOR pathway.
PHARMACOLOGICAL RESEARCH
(2021)
