Article
Biochemistry & Molecular Biology
Ziwen Wang, Qiaoli Wang, Wenshen Zhong, Feng Liang, Yuying Guo, Yifei Wang, Zhiping Wang
Summary: This study aimed to explore the moisturizing and antioxidant effects of Artemisia argyi essence liquid (AL) and clarify the potential mechanism underlying those effects. The results showed that AL enhanced the expression of AQP3 and HAS2 by activating the EGFR-mediated STAT3 and MAPK signaling pathways. In addition, AL played an antioxidant role by inhibiting the NF-κB signaling pathway and activating the Nrf2/HO-1 signaling pathway, thereby increasing the expression of antioxidant enzymes (GPX1, SOD2) and decreasing the production of reactive oxygen species (ROS). This study revealed the potential use of AL as a moisturizing and antioxidant cosmetic ingredient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Pengxiao Chen, Qi Bai, Yanting Wu, Qiongzhen Zeng, Xiaowei Song, Yuying Guo, Pengjun Zhou, Yao Wang, Xiaofeng Liao, Qiaoli Wang, Zhe Ren, Yifei Wang
Summary: The essential oil of Artemisia argyi H. Lev. and Vaniot inhibits NLRP3 inflammasome activation and shows therapeutic potential against NLRP3-driven diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhanhu Cui, Mengzhi Li, Xiaojing Han, Hongyan Liu, Chao Li, Huasheng Peng, Dahui Liu, Xianzhang Huang, Zhongyi Zhang
Summary: This study investigated the morphogenetic process and metabolites of glandular trichomes (GTs) and non-glandular trichomes (NGTs) in Artemisia argyi H. Lev. & Vaniot. It was found that GTs are the key tissues for the production of flavonoid and terpenoid metabolites in A. argyi. The study provides a theoretical basis and technical approach for understanding the regulatory mechanisms of trichome development and bioactive metabolite biosynthesis in A. argyi.
Article
Chemistry, Applied
Yun-hong Zhang, Zhu-tao Shao, Guang-ming Bi, Yi-wei Sun, Yu-meng Wang, Da-li Meng
Summary: In this study, various bioactive compounds were isolated from Artemisia argyi, with the guaianolide sesquiterpenoid Argyin A showing excellent anti-inflammatory activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Yanhua Wu, Junfeng Shen, Liyan Wang, Yinzhi Lin, Shiori Kojima, Shoshiro Okada, Kazuo Umezawa
Summary: Safe and effective nonsteroidal anti-inflammatory drugs are necessary, and adding amino acids to cultures of microorganisms may increase the likelihood of discovering new secondary metabolites. Two new compounds, myceliostatins A and B, with the myceliothermophin structure were isolated from a methionine-enriched culture of Myceliophthora thermophila. Both compounds exhibited inhibition of LPS-induced NO production and had anti-inflammatory and antioxidant effects by suppressing NF-KB activity and reactive oxygen species production.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Maryam Abbasi, Mohammad Mahboubi-Rabbani, Khosrow Kashfi, Hojjat Sadeghi-Aliabadi
Summary: Multiple lines of evidence support the critical role of the NF-kappa B signaling pathway in carcinogenesis, with its activation promoting cell proliferation and inhibiting apoptosis in cancer. Inhibition of NF-kappa B through blocking IKK-alpha/beta enzymes and protecting p65 from acetylation and phosphorylation can lead to tumor suppression. This study utilized a virtual screening approach to identify potential inhibitors for both NF-kappa B and I kappa B proteins, resulting in the identification of three top-ranked compounds for each protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Muhammad Waleed Baig, Humaira Fatima, Nosheen Akhtar, Hidayat Hussain, Mohammad K. Okla, Abdulrahman Al-Hashimi, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan-ul Haq
Summary: Daturaolone, a natural compound isolated from Datura innoxia Mill., shows potential anti-inflammatory properties following Lipinski's drug-likeliness rule. In silico, in vitro, and in vivo evaluations demonstrate its ability to inhibit inflammatory responses and target various inflammatory mediators. Detailed mechanistic studies are needed to further confirm and extend these findings.
Article
Biochemistry & Molecular Biology
Gianfranco Fontana, Natale Badalamenti, Maurizio Bruno, Davide Castiglione, Monica Notarbartolo, Paola Poma, Alberto Spinella, Marco Tutone, Manuela Labbozzetta
Summary: This study investigates the cytotoxicity of natural triterpenes oleanolic acid (OA) and lupeol (LU) on leukemia cells. Six new semi-synthetic triterpenes were synthesized and characterized, and their pharmacological mechanism of action was studied. The lupane-like compounds showed higher activity than the precursor, while the oleane-like compounds had more complex behavior. Furthermore, the study found that these compounds interacted with the nuclear factor kappa B (NF-kappa B) pathway, possibly inhibiting NF-kappa B activity to exert anti-cancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Biochemistry & Molecular Biology
Wenqian Yang, Fei Shao, Jiexin Wang, Tong Shen, Yu Zhao, Xueyan Fu, Liming Zhang, Hangying Li
Summary: This study investigated the effect of ethyl acetate extract of Artemisia argyi (AaEA) on ConA-induced Immunological Liver Injury (ILI) and the mechanism of regulating Bax/Bcl-2 and TLR4/MyD88/NF-kappa B signaling pathways. The results showed that AaEA could prevent ILI by reducing inflammation and oxidative stress, as well as regulating the expression levels of key proteins. Additionally, AaEA contains multiple components with anti-inflammatory and liver protective activities.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wei Liu, Hao Zhang, Yun-yi Hou, Rui-yi Hu, Jun-jie Zhang, Xuan Chen, Shuang Wang, Jun-nan Hu, Zi Wang, Wei Li
Summary: This study evaluates the protective effects of arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, against cisplatin-induced intestinal toxicity. The results showed that AFG can alleviate cisplatin-induced gastrointestinal damage and inhibit cell apoptosis by regulating the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Ma. Sheila M. de Jesus, Allan Patrick G. Macabeo, John Donnie A. Ramos, Von Novi O. de Leon, Kaori Asamitsu, Takashi Okamoto
Summary: The effects of spirobisindole alkaloids from the Philippine medicinal plant on HIV gene transcription were investigated, and it was found that one of the alkaloids showed inhibitory activity against viral replication. This alkaloid may serve as an inspiration for the discovery of new alkaloid-based anti-HIV derivatives.
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyeon-Ji Song, Dong-Uk Shin, Ji-Eun Eom, Kyung Min Lim, Eun Yeong Lim, Young In Kim, Ha-Jung Kim, Ju Hye Song, Myeongkuk Shim, Hyeonjeong Choe, Gun-Dong Kim, So-Young Lee, Hee Soon Shin
Summary: Particulate matter (PM) induces oxidative stress and inflammation, leading to respiratory diseases. Artemisia gmelinii extract (AGE) has been found to have antioxidant and anti-inflammatory effects. In this study, the protective effects of AGE on PM-induced lung inflammation were investigated using a mouse model. The results showed that AGE effectively reduced the expression of inflammatory chemokines, neutrophil extracellular trap formation, and the total number of inflammatory cells in the bronchoalveolar lavage fluid. It also suppressed the NF-κB/MAPK signaling pathway while promoting the NRF2/HO-1 signaling pathway in lung tissues. Based on these findings, AGE administration could be an effective approach for preventing and treating PM-induced respiratory inflammation.
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)