Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

(2019) Rebecca A. Sager et al.   Cell Reports

The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation

(2019) Rebecca Mercier et al.   Nature Communications

The Hsp90 Chaperone: 1H and 19F Dynamic NMR Spectroscopy Reveals A Perfect Enzyme.

(2019) Brian L. Lee et al.   BIOCHEMISTRY

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

(2019) Wanping Xu et al.   Nature Communications

Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis

(2019) Alexander J. Baker-Williams et al.   Cell Reports

Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome

(2018) Brandon Ho et al.   Cell Systems

A chemical compound inhibiting the Aha1–Hsp90 chaperone complex

(2017) Sandrine C. Stiegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone-client interactions: Non-specificity engenders multifunctionality

(2017) Philipp Koldewey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 activator Aha1 drives production of pathological tau aggregates

(2017) Lindsey B. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

(2017) Lindsey B. Shelton et al.   Frontiers in Neuroscience

Mechanisms of Hsp90 regulation

(2016) C. Prodromou   BIOCHEMICAL JOURNAL

Review: The HSP90 molecular chaperone-an enigmatic ATPase

(2016) Laurence H. Pearl   BIOPOLYMERS

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism

(2016) Andrea Schulze et al.   Nature Chemical Biology

Importance of cycle timing for the function of the molecular chaperone Hsp90

(2016) Bettina K Zierer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

(2016) Mark R. Woodford et al.   Nature Communications

Importance of cycle timing for the function of the molecular chaperone Hsp90

(2016) Bettina K Zierer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mechanism of Hsp90 ATPase Stimulation by Aha1

(2016) Annemarie Wolmarans et al.   Scientific Reports

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

(2016) Mark R. Woodford et al.   Cell Reports

Mechanistic Asymmetry in Hsp90 Dimers

(2015) Julia M. Flynn et al.   JOURNAL OF MOLECULAR BIOLOGY

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

(2015) Diana M. Dunn et al.   Cell Reports

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein

(2015) Angela Pacitto et al.   Open Biology

Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90α/Aha1 Complex in PC3-MM2 Cells

(2014) Suman Ghosh et al.   ACS Chemical Biology

Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions

(2014) Bettina K. Zierer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aha1 Can Act as an Autonomous Chaperone to Prevent Aggregation of Stressed Proteins

(2014) Vishwadeepak Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel C-Terminal Homologue of Aha1 Co-Chaperone Binds to Heat Shock Protein 90 and Stimulates Its ATPase Activity in Entamoeba histolytica

(2014) Meetali Singh et al.   JOURNAL OF MOLECULAR BIOLOGY

A Mutation in the Catalytic Loop of Hsp90 Specifically Impairs ATPase Stimulation by Aha1p, But Not Hch1p

(2014) Natalie K. Horvat et al.   JOURNAL OF MOLECULAR BIOLOGY

Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

(2014) Mehdi Mollapour et al.   MOLECULAR CELL

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

Stressing the Development of Small Molecules Targeting HSP90

(2013) L. Neckers et al.   CLINICAL CANCER RESEARCH

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potential synergy between tau aggregation inhibitors and tau chaperone modulators

(2013) Laura J Blair et al.   Alzheimers Research & Therapy

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins

(2012) Liang Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

(2012) Wanping Xu et al.   MOLECULAR CELL

The Co-Chaperone Hch1 Regulates Hsp90 Function Differently than Its Homologue Aha1 and Confers Sensitivity to Yeast to the Hsp90 Inhibitor NVP-AUY922

(2012) Heather Armstrong et al.   PLoS One

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

(2011) Mehdi Mollapour et al.   MOLECULAR CELL

Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex

(2011) Daniel R. Southworth et al.   MOLECULAR CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Cdc37-Hsp90 Complexes Are Responsive to Nucleotide-induced Conformational Changes and Binding of Further Cofactors

(2010) Andreas M. Gaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

(2010) Atanas V. Koulov et al.   MOLECULAR BIOLOGY OF THE CELL

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

(2010) Mehdi Mollapour et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Charged Linker Region Is an Important Regulator of Hsp90 Function

(2009) Otmar Hainzl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

(2009) Moritz Mickler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

(2008) J. L. Holmes et al.   CANCER RESEARCH

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

(2008) Cara K. Vaughan et al.   FEBS Journal

Conserved Conformational Changes in the ATPase Cycle of Human Hsp90

(2008) Klaus Richter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY