Importance of cycle timing for the function of the molecular chaperone Hsp90

Hsp90: Breaking the Symmetry

(2015) Matthias P. Mayer et al.   MOLECULAR CELL

Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

(2014) Parul Mishra et al.   MOLECULAR CELL

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

(2014) Oliver Robin Lorenz et al.   MOLECULAR CELL

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

(2012) Joanna Soroka et al.   MOLECULAR CELL

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

(2012) Christian N. Cunningham et al.   PROTEIN SCIENCE

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Global Functional Map of the p23 Molecular Chaperone Reveals an Extensive Cellular Network

(2011) Frank J. Echtenkamp et al.   MOLECULAR CELL

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

(2010) Anna Zurawska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SEDVIEW, Real-time Sedimentation Analysis

(2010) David B. Hayes et al.   MACROMOLECULAR BIOSCIENCE

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

(2010) Atanas V. Koulov et al.   MOLECULAR BIOLOGY OF THE CELL

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

(2009) Moritz Mickler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation

(2009) D. A. Hubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

(2008) Cara K. Vaughan et al.   FEBS Journal

Multiple Conformations of E. coli Hsp90 in Solution: Insights into the Conformational Dynamics of Hsp90

(2008) Kristin A. Krukenberg et al.   STRUCTURE