Article
Psychology, Biological
Marcia C. Chavez, Maria Ragusa, Kayla Brooks, Chakeer Drake-Frazier, Isabella Ramos, Megan Zajkowski, Kalynn M. Schulz
Summary: The study found that prenatal and adolescent stress have different effects on fear memory, with no cumulative effects observed in males and females.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Neurosciences
Laura C. Fox, Jamie L. Scholl, Geralyn M. Palmer, Gina L. Forster, Michael J. Watt
Summary: Mild traumatic brain injuries (mild TBIs) commonly occur in young adults in high-stress environments. Sex differences have been observed in the development of post-concussive anxiety and PTSD-like behaviors. Progesterone, which has neuroprotective properties, does not effectively prevent psychological symptoms associated with mild TBI in male and female rats. Overall, both sex and estrous cycle contribute to psychological outcomes following mild TBI, and sex steroids may play a role as a moderator rather than a treatment for these symptoms.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Behavioral Sciences
Anagha M. Kaluve, Jenny T. Le, Bronwyn M. Graham
Summary: Recent meta-analyses have shown that female rodents do not have greater variability than males across various traits. Despite anxiety disorders being more prevalent in women, male-only samples are still widely used in preclinical studies. This study found no evidence for increased variability in females compared to males. Staged females showed lower variability compared to unstaged females.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Clinical
Maya T. Schenker, Sevil Ince, Luke J. Ney, Chia-Ming K. Hsu, Daniel V. Zuj, Amy S. Jordan, Christian L. Nicholas, Kim L. Felmingham
Summary: Sleep plays a crucial role in fear conditioning, extinction learning, and extinction recall. However, subjective sleep measures were not found to be associated with fear conditioning or extinction processes in individuals with PTSD. Exploratory analyses revealed that shorter sleep onset latency and greater sleep efficiency were associated with improved extinction recall in women with higher PTSD symptom severity.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Clinical Neurology
Jeehye Seo, Katelyn Oliver, Carolina Daffre, Kylie N. Moore, Samuel Gazecki, Natasha B. Lasko, Mohammed R. Milad, Edward F. Pace-Schott
Summary: Sleep disturbances may increase the risk of developing posttraumatic stress disorder (PTSD). Different patterns of neural activations during fear extinction may be observed in individuals with PTSD compared to trauma-exposed controls.
Article
Pharmacology & Pharmacy
Shihao Huang, Yu Zhou, Feilong Wu, Cuijie Shi, He Yan, Liangpei Chen, Chang Yang, Yixiao Luo
Summary: This study found that berberine combined with extinction training can effectively promote the extinction of fear memories and prevent their reinstatement and spontaneous recovery. This finding provides a new potential avenue for the treatment of fear-related disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Paloma Molina Hernandes, Matheus Fitipaldi Batistela, Jefferson Manoel Nascimento-Silva, Alana Tercino Frias, Melina Matthiesen, Alline Cristina Campos, Thelma Anderson Lovick, Helio Zangrossi Jr
Summary: Clinical and preclinical studies have shown that cannabidiol (CBD) has anxiolytic effects, but its effects on panic disorder and in females have been less explored. This study compared the effects of CBD on male and female rats and mice in response to panicogenic challenges. The results showed that CBD had panicolytic effects in female rats and mice, but not in males. In rats, the effects were influenced by the estrous cycle, with the most significant response in the late diestrus phase. Higher doses were required to elicit effects in mice, and the estrous cycle had no effect.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Itamar Lerner, Shira M. Lupkin, Alan Tsai, Anosha Khawaja, Mark A. Gluck
Summary: REM sleep plays a crucial role in modulating fear memories consolidation, impacting the development of PTSD. The findings suggest that REM sleep impairs recall of original threat memories but enhances the ability to generalize these memories in novel situations.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Clinical Neurology
Anne Richards, Sabra S. Inslicht, Leslie M. Yack, Thomas J. Metzler, J. Russell Huie, Laura D. Straus, Cassandra Dukes, Samantha Q. Hubachek, Kim L. Felmingham, Daniel H. Mathalon, Steven H. Woodward, Thomas C. Neylan
Summary: This study examines the relationship between emotional learning and REM sleep in trauma-exposed participants using fear-potentiated startle (FPS) and nap sleep protocol. The results show that safety learning is positively correlated with REM sleep and REM sleep is related to rapid extinction learning. Moreover, the study reveals unexpected effects of PTSD symptoms and biological sex on the learning-sleep relationship.
Article
Multidisciplinary Sciences
Devin Rocks, Mamta Shukla, Laila Ouldibbat, Silvia C. Finnemann, Achyuth Kalluchi, M. Jordan Rowley, Marija Kundakovic
Summary: This study provides evidence that 3D chromatin structure differs between male and female mouse brains and undergoes dynamic remodeling during the female ovarian cycle. The study also shows that female-specific 3D genome dynamics affect neuronal gene expression and brain disorder-relevant genes, and could play a role in reproductive hormone-induced brain plasticity and female-specific risk for brain disorders.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Khadijah Shanazz, Rachael Dixon-Melvin, Rebecca Nalloor, Riya Thumar, Almira I. Vazdarjanova
Summary: According to animal experiments, there are differences in the expression of fear memories between female and male rats. Female rats tend to express fear memories through active motor responses, which is referred to as "Anxioescapic" behavior strategy. There is no significant difference in fear learning between female and male rats.
Article
Psychiatry
Rachel Ahrenholtz, Jaryd Hiser, Marisa C. Ross, Anthony Privratsky, Anneliis Sartin-Tarm, G. Andrew James, Josh M. Cisler
Summary: The study identified three distinct neurocircuitry biotypes among women with PTSD, each associated with different neurocognitive features and clinical symptoms. This highlights the importance of considering different biotypes in PTSD research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Biological
Milene C. Carvalho, Karina Genaro, Christie R. A. Leite-Panissi, Thelma A. Lovick
Summary: Studies have shown that male and female rats in different estrous cycle stages exhibit different responses in anxiety-like tests. While males and proestrus females show a clear fear response in conditioning and testing, responses vary in other conditions, highlighting the importance of estrous cycle stage in behavioral testing.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Psychiatry
Delara Emtyazi, Thallita Kelly Rabelo, Hailey Katzman, Ana Carolina Campos, Mustansir Diwan, Darryl Gidyk, Patricia Rabelo dos Santos, Peter Giacobbe, Nir Lipsman, Isabelle Aubert, Clement Hamani
Summary: Studying sex differences in preclinical models of posttraumatic stress disorder (PTSD) is significantly important. The study observed that female rats exposed to fear conditioning and extinction displayed reduced freezing during tone recall and a lower latency to feed in the novelty suppression of feeding (NSF) test. The different estrogen phases of the cycle did not affect the extinction performance of female rats. WE males and females showed increased freezing during tone and context recall, while WE males exhibited anxiety-like responses in the NSF test compared to SE animals. WE females buried fewer marbles than their SE counterparts. Further investigation is needed to validate these findings and understand the underlying mechanisms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Zhe Yu, Alexandre Kisner, Amy Bhatt, Abigail M. Polter, Paul J. Marvar
Summary: This study examined the role of angiotensin II receptor type 1 (AT1R) neurons in the central amygdala (CeA) in fear and anxiety-related behavior using AT1R transgenic mice. It was found that AT1R+ neurons were localized to GABA expressing neurons in the CeL, and their deletion enhanced extinction learning. Furthermore, the application of angiotensin II increased inhibitory synaptic currents and decreased the excitability of CeL-AT1R+ neurons. These findings provide new insights into the neurobiological mechanisms underlying fear extinction.
Article
Psychology, Biological
Ihori Kobayashi, Joseph Lavela, Kimberly Bell, Thomas A. Mellman
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Psychiatry
Yuanxiu Chen, Xin Li, Ihori Kobayashi, Daisy Tsao, Thomas A. Mellman
PSYCHIATRY RESEARCH
(2016)
Article
Clinical Neurology
Kimberly A. Bell, Ihori Kobayashi, Yuanxiu Chen, Thomas A. Mellman
JOURNAL OF SLEEP RESEARCH
(2017)
Article
Clinical Neurology
Thomas Alan Mellman, Kimberly Ann Bell, Soleman Hassan Abu-Bader, Ihori Kobayashi
Article
Clinical Neurology
Thomas Alan Mellman, Kimberly Ann Bell, Soleman Hassan Abu-Bader, Ihori Kobayashi
Article
Clinical Neurology
Victor R. Santos, Ihori Kobayashi, Robert Hammack, Gregory Danko, Patrick A. Forcelli
Article
Psychiatry
Kimberly A. Bell, Ihori Kobayashi, Ameenat Akeeb, Joseph Lavela, Thomas A. Mellman
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2019)
Article
Psychiatry
Ihori Kobayashi, Thomas A. Mellman, Ashley Cannon, Imani Brown, Linda Boadi, Mary Katherine Howell, Pewu Lavela, Ishaan Sandhu
Summary: The study found that participants who received suvorexant after exposure therapy in the evening had increased N3 sleep and decreased N2 sleep and rapid eye movement latency. Although there was greater habituation between exposure sessions with suvorexant, there was no significant difference in the reduction of PTSD severity from baseline to 1-week follow-up between groups. Further research with larger samples is needed to determine the clinical applications of enhancing exposure therapy with suvorexant.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Thomas A. Mellman, Kiya Birku, Ishaan Sandhu, Pewu Lavela, Ihori Kobayashi
Summary: This study aimed to evaluate the effectiveness of using Zorexant for the treatment of trauma-related insomnia. The results showed that Zorexant can alleviate insomnia symptoms in patients, but there was no significant difference in medication effects. The increased duration of REM segments in the Zorexant group correlated with a reduction in PTSD symptoms.
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Psychology, Clinical
Ihori Kobayashi, Eve M. Sledjeski, Douglas L. Delahanty
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2019)
Meeting Abstract
Psychiatry
Thomas A. Mellman, Nancy Cowdin, Ihori Kobayashi
PSYCHOSOMATIC MEDICINE
(2018)
Article
Psychology, Clinical
Ihori Kobayashi, Thomas A. Mellman, Duaa Altaee, Mary Katherine Howell, Joseph Lavela
JOURNAL OF TRAUMATIC STRESS
(2016)
Article
Clinical Neurology
Ihori Kobayashi, Mary Katherine Howell
SLEEP MEDICINE CLINICS
(2018)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)