Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

Drug Treatment of Primary Insomnia: A Meta-Analysis of Polysomnographic Randomized Controlled Trials

(2014) Alexander Winkler et al.   CNS DRUGS

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

(2014) David Michelson et al.   LANCET NEUROLOGY

Orexin receptor antagonists: a new treatment for insomnia?

(2014) Dieter Riemann et al.   LANCET NEUROLOGY

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

(2013) C J Winrow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders

(2013) Michihiro Mieda et al.   CNS DRUGS

When does a difference make a difference? Interpretation of number needed to treat, number needed to harm, and likelihood to be helped or harmed

(2013) L. Citrome et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Insomnia

(2013) Daniel J. Buysse   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System

(2013) Andrew D. Krystal et al.   JOURNAL OF CLINICAL PSYCHIATRY

First-in-class insomnia drug on the brink of approval nod

(2013) Randy Osborne   NATURE REVIEWS DRUG DISCOVERY

Meta-Analysis of On-the-Road Experimental Studies of Hypnotics: Effects of Time After Intake, Dose, and Half-Life

(2013) T. Roth et al.   Traffic Injury Prevention

Update on emerging drugs for insomnia

(2012) Shannon Sullivan   EXPERT OPINION ON EMERGING DRUGS

Ramelteon in the treatment of chronic insomnia: systematic review and meta-analysis

(2012) J. Liu et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Insomnia

(2012) Maryann C. Deak et al.   NEUROLOGIC CLINICS

Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant

(2012) W. J. Herring et al.   NEUROLOGY

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

(2010) John Gatfield et al.   ChemMedChem

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Compelling or irrelevant? Using number needed to treat can help decide

(2008) L. Citrome   ACTA PSYCHIATRICA SCANDINAVICA

Antipsychotics for the treatment of schizophrenia: likelihood to be helped or harmed, understanding proximal and distal benefits and risks

(2008) Leslie Citrome et al.   Expert Review of Neurotherapeutics