Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome

Therapeutic Antisense Oligonucleotides Are Coming of Age

(2019) C. Frank Bennett   Annual Review of Medicine

Is Targeting of Compensatory Ion Channel Gene Expression a Viable Therapeutic Strategy for Dravet Syndrome?

(2019) Lori L. Isom   Epilepsy Currents

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases

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Diagnostic outcomes for genetic testing of 70 genes in 8565 patients with epilepsy and neurodevelopmental disorders

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Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

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Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy

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A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome

(2018) Morgana Favero et al.   JOURNAL OF NEUROSCIENCE

The phenotype of SCN8A developmental and epileptic encephalopathy

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Prominent role of forebrain excitatory neurons in SCN8A encephalopathy

(2018) Rosie K A Bunton-Stasyshyn et al.   BRAIN

Neuronal mechanisms of mutations in SCN8A causing epilepsy or intellectual disability

(2018) Yuanyuan Liu et al.   BRAIN

The therapeutic potential of RNA regulation in neurological disorders

(2018) Jolien Roovers et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

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ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

(2017) Lindsay A. Becker et al.   NATURE

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

SCN8Aencephalopathy: Research progress and prospects

(2016) Miriam H. Meisler et al.   EPILEPSIA

The phenotypic spectrum of SCN8A encephalopathy

(2015) J. Larsen et al.   NEUROLOGY

Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy

(2015) Jacy L. Wagnon et al.   Frontiers in Neurology

Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy

(2014) Jacy L. Wagnon et al.   HUMAN MOLECULAR GENETICS

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

(2014) Yuntao Duan et al.   eLife

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

(2013) A. R. Miller et al.   GENES BRAIN AND BEHAVIOR

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009

(2010) Anne T. Berg et al.   EPILEPSIA

Exaggerated emotional behavior in mice heterozygous null for the sodium channelScn8a(Nav1.6)

(2008) B. C. McKinney et al.   GENES BRAIN AND BEHAVIOR

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols