Review
Pharmacology & Pharmacy
Manman Qin, Yuqing Qian, Lu Huang, Chao Zhong, Mingdong Li, Jun Yu, Huanwen Chen
Summary: Extraction electrospray ionization mass spectrometry (EESI-MS) enables effective ionization of trace molecules in complex samples without sample pretreatment, providing high sensitivity, selectivity, and response speed. It also allows for advanced functionalization of high-energy molecular species. This article systematically reviews the effects of operating conditions on the analytical performance of EESI-MS for various pharmaceutical compounds and introduces its potential application in molecular functionalization for drug discovery.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Seyedeh Malihe Hoseini, Somayeh Namroodi, Amir Sayadshirazi, Annalisa Zaccaroni
Summary: The study found that little information is available on the Caspian seal's exposure to contaminants, especially in Southern sub-populations. Tissue samples collected from 20 Caspian seals revealed the presence of trace elements and pesticides in various body matrices. Age and sex-related variations were observed in the concentrations of certain contaminants. High levels of mercury and low levels of zinc were detected, raising concerns about the reproductive health of seals. Similarly, the levels of DDTs detected were within the range known to cause adverse reproductive effects in marine mammals. Therefore, pollutant monitoring is crucial for the conservation of the Caspian seal.
Article
Chemistry, Multidisciplinary
Kai Niu, Yuying Zhang, Jiping Chen, Xianbo Lu
Summary: Covalent organic frameworks (COFs) are attractive materials for energy storage, catalysis, sorption, and sensing due to their porosity, stability, and tunable structure. However, their low conductivity limits their application in electrochemical sensing. In this study, an aza-fused x-conjugated COFs with carbonyl groups (COF1) was synthesized and used as electrode materials in electrochemical sensing for the first time. The COF1-based biosensor showed improved current response compared to the electrode without COF1, demonstrating the enhancing effect of carbonyl groups on signal detection.
Article
Chemistry, Multidisciplinary
Weixiang Li, Jianghui Sun, Yan Wang, Jinping Qiao, Lixin He, Jin Ouyang, Na Na
Summary: The TEMPO-electrocatalyzed acceptorless dehydrogenation of tetrahydroquinoline, which is a green synthesis and hydrogen storage transformation, was investigated by coupling an electrocatalytic system with in situ extraction electrospray ionization mass spectrometry. Dynamic changes in important species and intermediates were monitored, leading to an updated understanding of AD.
CHEMICAL COMMUNICATIONS
(2021)
Article
Food Science & Technology
Xueyan Yuan, Xiaoping Zhang, Jiaquan Xu, Jianhua Ye, Zhendong Yu, Xinglei Zhang
Summary: In this study, an internal extractive electrospray ionization mass spectrometry (iEESI-MS) method was developed to analyze active metabolites in ginseng samples without pretreatment. A total of 44 metabolites, including 32 ginsenosides, 6 sugars, and 6 organic acids, were identified in the ginseng samples. The study demonstrated that iEESI-MS-based metabolite fingerprints can be used to successfully discriminate different cultivation conditions of ginseng, providing an alternative solution for quality identification of plant drugs.
Article
Chemistry, Medicinal
Margaux Fresnais, Siwen Liang, Marius Breitkopf, Joshua Raoul Lindner, Emmanuelle Claude, Steven Pringle, Pavel A. Levkin, Konstantin Demir, Julia Benzel, Julia Sundheimer, Britta Statz, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Juergen Burhenne, Remi Longuespee
Summary: Desorption/ionization-mass spectrometric methods are advantageous for the analysis of solid biological matrices. The development of drug quantification assays using DESI has been challenging, but new prototype source setups show promise for targeted quantitative analyses.
Article
Plant Sciences
Zi-Dong Qiu, Xiaoping Zhang, Xu-Ya Wei, Konstantin Chingin, Jia-Quan Xu, Wei Gao, Bin Yang, Shuang-Long Wang, Ting Tan, E-Hu Liu, Hai-Yu Xu, Guang-Hong Cui, Juan Guo, Ya-Nan Wang, Ye Shen, Yu-Jun Zhao, Huan-Wen Chen, Chang-Jiang-Sheng Lai, Lu-Qi Huang
Summary: This study aimed to develop a complete molecular mechanism exploration strategy in the complex medicinal herb decocting system, clarifying the internal molecular mechanism of processing detoxification on Aconitum, and exploring valid approaches for detoxification. By using an advanced online real-time platform, the study successfully characterized components in the complex Aconitum decocting system, discovered that fat meat could detoxify Aconitum directionally while preserving therapeutic effects, and proposed a novel reaction pathway based on nucleophilic substitution mechanism.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Suling Zhang, Ziluo Hua, Weixuan Yao, Ting Lu, Yueping Chen, Zheng Fang, Hongting Zhao
Summary: This study explored the potential of utilizing corn straw-derived biochar for environmental sample pretreatment. Magnetic biochar prepared through magnetization and carbonization process showed efficient extraction performance for trace organophosphorus pesticides, demonstrating promising potentials for environmental analysis.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemistry & Molecular Biology
Xiaoping Zhang, Ze-Yan Chen, Zi-Dong Qiu, Mingxing Liu, Jiaquan Xu, Chang-Jiang-Sheng Lai, Vladimir Frankevich, Konstantin Chingin
Summary: A method based on internal extractive electrospray ionization mass spectrometry (iEESI-MS) was developed to characterize chemical components of Panax notoginseng samples grown under different conditions, allowing for rapid molecular characterization and classification of Panax notoginseng. The study identified key characteristic indicators, such as sucrose content, which can be used to discriminate origin, commercial specifications, and cultivation conditions of Panax notoginseng samples. This method shows potential for quality assessment of traditional herbal medicines and pharmaceutical and clinical analysis.
Article
Engineering, Environmental
Varun Kumar, Jay G. Slowik, Urs Baltensperger, Andre S. H. Prevot, David M. Bell
Summary: This study examines the composition and evolution of secondary organic aerosol (SOA) formed by the reactions of aromatic VOCs with OH and NO3 radicals. The results show that the SOA formed by the oxidation of VOCs by OH radicals is dominated by monomers, while the SOA formed by NO3 radicals consists mainly of dimers. The study also highlights the importance of particle-phase reactions in the formation and degradation of SOA. Rating: 8/10
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Vera H. de Kleijne, Annemieke C. Heijboer, Robert de Jonge, Mariette T. Ackermans
Summary: The addition of supercharging reagents can enhance ionization efficiencies for some hormones, but it does not significantly improve sensitivity in hormone measurements with LC-MS/MS.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Meteorology & Atmospheric Sciences
Demetrios Pagonis, Pedro Campuzano-Jost, Hongyu Guo, Douglas A. Day, Melinda K. Schueneman, Wyatt L. Brown, Benjamin A. Nault, Harald Stark, Kyla Siemens, Alex Laskin, Felix Piel, Laura Tomsche, Armin Wisthaler, Matthew M. Coggon, Georgios Gkatzelis, Hannah S. Halliday, Jordan E. Krechmer, Richard H. Moore, David S. Thomson, Carsten Warneke, Elizabeth B. Wiggins, Jose L. Jimenez
Summary: The study deployed EESI-MS for airborne measurements of biomass burning aerosol, achieving quantitative measurements of nitrocatechol and levoglucosan concentrations up to 7 km. The intercomparison with CHARON PTR-MS and AMS showed good correlation between EESI-MS and CHARON PTR-MS but a greater difference with AMS for levoglucosan concentrations. The total EESI-MS signal correlated well with total organic aerosol measured by AMS.
ATMOSPHERIC MEASUREMENT TECHNIQUES
(2021)
Article
Chemistry, Analytical
Chao Liu, Jiafa Zeng, Pablo Sinues, Mingliang Fang, Zhen Zhou, Xue Li
Summary: SESI-HRMS is a direct mass spectrometry technique that can identify trace VOCs in real time, but further development of absolute quantification methods is needed.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Hiromori Murashima, Akimasa Fujihara
Summary: The study investigated chiral recognition between amino acids and monosaccharides in the gas phase as a model for chemical evolution in interstellar molecular clouds. Results showed that the optical properties of Trp in the clusters induced by 285-nm photoexcitation were useful for identifying and quantifying pentose enantiomers. Additionally, pentose enantiomeric excess in solution could be determined from relative abundances observed in a single product ion spectrum of 285-nm photoexcited hydrogen-bonded clusters of H+(L-Trp) and pentose.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Jingyun Huang, Jinian Shu, Bo Yang, Yedong Guo, Zuojian Zhang, Kui Jiang, Zhen Li
Summary: A thermal desorption associative ionization time-of-flight mass spectrometer was developed for ultrasensitive detection of semi-volatile chemical warfare agents. The excited-state CH2Cl2-induced associative ionization method showed excellent sensitivity towards CWAs, improving LODs by 2-76 times compared to other methods. The experiment demonstrated potential for significantly enhancing CWA detection in the future.
Article
Chemistry, Physical
Liang Lv, Yi-Ru Hao, Niankun Guo, Jing Sun, Tianshan Song, Hui Xue, Keke Huang, Qin Wang
Summary: The study introduces the development of a N-doped carbon-coated CeO2 hollow structure with massive oxygen vacancy (Vo-CeO2-NC) catalyst, which exhibits high oxygen reduction reaction performance. The synergistic effect of oxygen vacancies and the N-doped carbon interface layer can promote the conductivity of CeO2 and significantly improve the catalyst's oxygen reduction reaction performance, as indicated by catalytic results and density functional theory calculations.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yingge Cong, Zhibin Geng, Qian Zhu, Hongwei Hou, Xiaofeng Wu, Xiyang Wang, Keke Huang, Shouhua Feng
Summary: By introducing a temperature-controlled cation-exchange approach, a unique dual-exsolution of CoFe alloy and Co metal in perovskite oxide was achieved, resulting in an alloy and metal co-decorated structure. The obtained composite exhibited enhanced catalytic activity and cycling stability as Li-O-2 battery cathode catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Zhiyu Shao, Qian Zhu, Yu Sun, Yuan Zhang, Yilan Jiang, Shiqing Deng, Wei Zhang, Keke Huang, Shouhua Feng
Summary: This study reports the synthesis of a NiS/NiFe2O4 composite through local metal-S coordination at the interface. The introduction of NiS/NiFe2O4 interfaces during plasma energy irradiation is confirmed by X-ray absorption fine structure and electron energy loss spectroscopy. Density functional theory calculations reveal that in situ phase reconfiguration is crucial for catalyzing the oxygen evolution reaction. This work provides a new compositing strategy for fast phase reconstruction of bifunctional catalysts.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Ran Zheng, Rui Su, Fan Xing, Qing Li, Botong Liu, Daguang Wang, Yechao Du, Keke Huang, Fei Yan, Jianfeng Wang, Huanwen Chen, Shouhua Feng
Summary: The application of rapid and accurate diagnostic methods can significantly improve the survival rates of colorectal cancer. In this study, a non-targeted metabolomic approach based on iEESI-MS was used to identify metabolite ions associated with the progression of colorectal cancer. A support vector machine model was built using 10 differential metabolite ions to distinguish early-stage colorectal cancer from normal tissues, with a high prediction accuracy of 92.6%. The biomarker panel, specifically lysophosphatidylcholine (LPC) (18:0), showed good diagnostic potential in differentiating early-stage colorectal cancer from advanced-stage colorectal cancer.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Zhinan Zhang, Haiming Cheng, Shiyong Teng, Keke Huang, Dayang Wang, Wensheng Yang, Renguo Xie
Summary: This paper introduces a metal halide hybrid material that exhibits thermally induced fluorescence transition, and successfully fabricates a thermochromic material with reversible and lower transition temperatures. Through the study of an organic-inorganic lead chloride hybrid crystal, it is found that the emission of the crystal changes from green to blue light when heated, and the transition process is verified by various experimental methods. In addition, this material has excellent cycling stability and low transition temperature, which is expected to be applied in the fields of anti-counterfeiting and information encryption.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jiali Yao, Zixu Zhang, Dayang Wang, Keke Huang, Wensheng Yang, Litao Sun, Renguo Xie, Narayan Pradhan
Summary: Inorganic and hybrid metal halides have attracted increasing interest due to their diverse structures and properties. Mechanochemistry is considered a universal synthetic approach for their synthesis. The library of metal halides includes various types of compounds, and the structure-property relationships are well revealed. This study provides fundamental guidance for developing new metal halides with selective optoelectronic and magnetic properties.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyu Shao, Xiaotian Wu, Xiaofeng Wu, Shouhua Feng, Keke Huang
Summary: Composite structures have gained increasing attention in energy storage and conversion fields due to their unique interfacial effects, lattice strain effects, electronic interactions, and strong interaction effects that greatly influence their catalytic performance. It is crucial to construct and investigate composite structures to develop high-performance energy-related catalysts. Spinel-type composites are considered promising candidates for catalytic materials in energy fields due to their versatility, low toxicity, low expense, and high natural abundance. This review provides an overview of different synthesis and modulation methods based on a deep understanding of the relationship between composite structure and activity.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Jie Wu, Zhiyu Shao, Beining Zheng, Yuan Zhang, Xiangdong Yao, Keke Huang, Shouhua Feng
Summary: Here, the method of molecular-beam-epitaxial growth (MBE) for precisely regulating the terminal surface with different exposed atoms on indium telluride (InTe) is reported, and the electrocatalytic performances toward hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are studied. The improved performances result from the exposed In or Te atoms cluster, which affects the conductivity and active sites. This work provides insights into the comprehensive electrochemical attributes of layered indium chalcogenides and exhibits a new route for catalyst synthesis.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Zhiyu Shao, Qian Zhu, Xiyang Wang, Jian Wang, Xiaofeng Wu, Xiangdong Yao, Yimin A. Wu, Keke Huang, Shouhua Feng
Summary: This study demonstrates the construction of strongly-interacted composites through selective exsolution of active materials and reveals their electronic structure characteristics using spatially resolved techniques, exhibiting high performance in the oxygen evolution reaction.
Article
Chemistry, Multidisciplinary
Zhiyu Shao, Xia Gao, Qian Zhu, Weifeng Zhao, Xiaotian Wu, Keke Huang, Shouhua Feng
Summary: By selectively doping different ions with different radii, the coordination sites of Co3O4 were modulated, leading to a higher intrinsic activity in the oxygen evolution reaction (OER) due to improved electrical conductivity and the formation of highly active Co3+/Co4+ species.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Feng Liu, Debayan Mondal, Kai Zhang, Ying Zhang, Keke Huang, Dayang Wang, Wensheng Yang, Priya Mahadevan, Renguo Xie
Summary: This article introduces plate-shaped copper-based halide hybrids with zero-dimensional structures, prepared successfully using long alkyl chain molecules, and studied in terms of photophysical properties and theoretical simulations. The results indicate the potential application of this hybrid material for lighting phosphors and optical communication micro-devices.
MATERIALS ADVANCES
(2021)
Article
Chemistry, Physical
Juan Jian, Wei Chen, Decheng Zeng, Limin Chang, Ran Zhang, Mingcheng Jiang, Guangtao Yu, Xuri Huang, Hongming Yuan, Shouhua Feng
Summary: The study introduces K2Fe4O7 nanocrystals grown on a nickel foam as an electrocatalyst for hydrogen and oxygen evolution reactions, demonstrating excellent stability and high current densities. The nano-KFO material shows promising potential for large-scale hydrogen production due to its efficient electrocatalytic performance in water splitting.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Multidisciplinary
Pan Hou, Mingwei Ma, Peng Zhang, Jingjie Cao, Hui Liu, Xingliang Xu, Huijuan Yue, Ge Tian, Shouhua Feng
Summary: A hollow core-shell magnetic zirconium hydroxide catalyst was synthesized and demonstrated to perform excellently in the catalytic transfer hydrogenation of biomass-derived molecules, showing potential for industrial applications.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Zhiyu Shao, Haihong Meng, Jing Sun, Niankun Guo, Hui Xue, Keke Huang, Feng He, Fengyu Li, Qin Wang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Lu Yao, Zhibin Geng, Wei Zhang, Xiaofeng Wu, Jinghai Liu, Liping Li, Xiyang Wang, Xiangyan Hou, Ke Xu, Keke Huang, Shouhua Feng
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
