Neuroimmune mechanisms of pain: Basic science and potential therapeutic modulators

Therapeutic implications of toll-like receptors in peripheral neuropathic pain

(2017) Krishan K. Thakur et al.   PHARMACOLOGICAL RESEARCH

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

(2016) Katarzyna Popiolek-Barczyk et al.   CURRENT MEDICINAL CHEMISTRY

The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation

(2016) Wenbin Wan et al.   Journal of Immunology Research

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation

(2016) Xing-Jun Liu et al.   Scientific Reports

Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord

(2014) Adee Heiman et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain

(2014) Amanda Ellis et al.   JOURNAL OF PAIN

Mast cells, glia and neuroinflammation: partners in crime?

(2013) Stephen D. Skaper et al.   IMMUNOLOGY

Progress in gene therapy for neurological disorders

(2013) Michele Simonato et al.   Nature Reviews Neurology

The efficacy of a glial inhibitor, minocycline, for preventing persistent pain after lumbar discectomy: A randomized, double-blind, controlled study

(2013) Valéria Martinez et al.   PAIN

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

The Effects of Pregabalin and the Glial Attenuator Minocycline on the Response to Intradermal Capsaicin in Patients with Unilateral Sciatica

(2012) Nicole M. Sumracki et al.   PLoS One

Dual Peripheral Actions of Immune Cells in Neuropathic Pain

(2011) Halina Machelska   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

(2011) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages

(2011) Russell P. Landry et al.   EXPERIMENTAL NEUROLOGY

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Spinal glial TLR4-mediated nociception and production of prostaglandin E2 and TNF

(2010) O Saito et al.   BRITISH JOURNAL OF PHARMACOLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming

(2010) Leah E. Hains et al.   JOURNAL OF PAIN

Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders

(2010) K.M. Ramos et al.   NEUROSCIENCE

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity

(2010) M.R. Hutchinson et al.   NEUROSCIENCE

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

(2010) Norikazu Kiguchi et al.   PAIN

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

(2009) P Rolan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Minocycline Treatment Inhibits Microglial Activation and Alters Spinal Levels of Endocannabinoids in a Rat Model of Neuropathic Pain

(2009) Leonardo Guasti et al.   Molecular Pain

Antidepressants Inhibit P2X4 Receptor Function: a Possible Involvement in Neuropathic Pain Relief

(2009) Kenichiro Nagata et al.   Molecular Pain

Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome

(2008) Luis Del Valle et al.   BRAIN BEHAVIOR AND IMMUNITY

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats

(2008) Joachim Scholz et al.   PAIN