Article
Chemistry, Physical
Mengyu Sun, Yanjuan Sang, Qingqing Deng, Zhengwei Liu, Jinsong Ren, Xiaogang Qu
Summary: A nanozyme-based NO generator, cerium oxide (CeO2)-AT, has been developed to selectively produce nitric oxide (NO) in cancer cells for tumor treatment. The generator can disrupt the mitochondrial respiratory chain of tumor cells and induce cell apoptosis by catalyzing the production of NO in the mitochondria of cancer cells. Furthermore, the generator can improve the performance of NO gas therapy by catalyzing H2O2 to produce O-2. This study provides a new approach for safe and specific cancer therapy using highly selective NO-based treatment.
Article
Chemistry, Multidisciplinary
Min-Ren Chiang, Ya-Hui Lin, Wei-Jie Zhao, Hsiu-Ching Liu, Ru-Siou Hsu, Tsu-Chin Chou, Tsai-Te Lu, I-Chi Lee, Lun-De Lun-De Liao, Shih-Hwa Chiou, Li-An Chu, Shang-Hsiu Hu
Summary: An electromagnetic messenger approach utilizing high-frequency magnetic fields (HFMF) to trigger nitric oxide (NO) release and electrical stimulation is developed for restoring brain function in traumatic brain injury.
Article
Chemistry, Multidisciplinary
Cristina Parisi, Francesca Moret, Aurore Fraix, Luca Menilli, Mariacristina Failla, Federica Sodano, Claudia Conte, Fabiana Quaglia, Elena Reddi, Salvatore Sortino
Summary: The biological activity of a molecular hybrid (DXNO-GR) combining doxorubicin (DOX) and nitric oxide (NO) has been studied against breast cancer cells. DXNO-GR shows higher cellular internalization compared to DOX and does not experience cell efflux in resistant cells. The cellular internalization of DXNO-GR is mediated by bovine serum albumin (BSA). DXNO-GR is not toxic in the dark but induces cell death following photoactivation with green light.
Article
Engineering, Electrical & Electronic
Zhen Zhang, Shen Shen, Zhenyan Liang, Stephan H. K. Eder, Ralph Kennel
Summary: This article proposes an enhanced constant current control method for wireless in-flight charging systems. By using an online-trained RBFNN, the expected constant current output for battery charging is ensured. The effectiveness of the proposed control scheme is validated with simulated and experimental results.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Chemistry, Physical
Yang Wang, Yafei Wen, Yun Qu, Zhichao Pei, Yuxin Pei
Summary: In this study, a thermal-responsive glycol-targeting nitric oxide nanogenerator was constructed by covalently conjugating thermal-responsive nitrosothiols on the surface of mesoporous silica-coated gold nanorods, then coating it with a supramolecular complex, and finally loading an alkyl radical initiator. The nanogenerator showed specific targeting ability to HepG2 cells and generated hyperthermia under near infrared irradiation, resulting in photothermal therapy as well as gas therapy and alkyl radical therapy. In vitro experiments demonstrated its biocompatibility and effective inhibition of HepG2 cell proliferation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yuce Li, Been Yoon, Anup Dey, Van Quy Nguyen, Jae Hyung Park
Summary: Nitric oxide (NO) is a versatile biological signaling molecule that has potential as an anticancer therapy. Targeted delivery of NO to tumors is necessary for better therapeutic effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yongyan Deng, Yupeng Wang, Fan Jia, Weifeng Liu, Dongfang Zhou, Qiao Jin, Jian Ji
Summary: This study reports a novel supramolecular prodrug nanoassemblies strategy that co-delivers nitric oxide and superoxide anion inducing chemotherapeutic agents for enhanced reactive nitrogen species effects in chemotherapy. The efficacy of this strategy was validated in hepatoma models, providing a new direction for cancer treatment.
Article
Engineering, Biomedical
Kesi Wang, Linping Jiang, Liyan Qiu
Summary: In this study, a nano-vesicular system IA-PEP was developed to efficiently deliver photosensitizer PEGylated indocyanine green and NO donor L-Arg, achieving a ternary synergistic treatment combining NO therapy, photodynamic therapy, and mild-temperature photothermal therapy under 808 nm laser irradiation. The potent anti-tumor efficacy of IA-PEP with complete tumor elimination was verified in vivo in nude mice bearing xenograft MCF-7 tumors.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Chenyi Huang, Jia Tang, Yuanqi Liu, Ting Chen, Junyang Qi, Shengjie Sun, Huisong Hao, Weiwei Zeng, Jing Zhao, Meiying Wu
Summary: This study developed a multifunctional nanocatalyst Cu-doped polypyrrole (CuP) as an intelligent nanoplatform to deliver the NO precursor BNN6 and specifically release NO in tumors. Through the synergistic effect of hyperthermia, oxidative damage, and NO burst, almost complete tumor elimination is achieved in vivo.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Shuting Zuo, Yan Zhang, Zhenyu Wang, Jing Wang
Summary: The study proposed a synergistic strategy that combines mitochondrial targeting, sonodynamic therapy (SDT), and nitric oxide (NO) gas therapy using a multifunctional nanoplatform. The results showed outstanding efficacy and reduced side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Zifan Pei, Huali Lei, Liang Cheng
Summary: Bioactive inorganic nanomaterials have attracted wide attention in cancer theranostics due to their unique physical and chemical properties, strong mechanical stability, and easy compounding with various carriers to achieve specific antitumor efficacy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yi Yan, Cheng-Han Wang, Shi-He Cui, Lin Zhai, Jing Sun, Xiao-Yu Liu, Xin Chen, Yi Sun, Hong-Gang Qian, Xiang Gao, Yi-Da Tang, Yuan-Jun Zhu, Yu-Jie Shi, Qiang Zhang, Jian-Cheng Wang
Summary: The synthesized caspase-3 responsive FDP polymer was used to deliver siRNA, promoting cell apoptosis through nitric oxide release and activation of caspase-3. In vivo results demonstrated the enhanced anti-cancer efficiency of FDP/siEGFR nanoplexes.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Cell Biology
Inesa Navasardyan, Benjamin Bonavida
Summary: The T cell-mediated immune response plays a key role in combating infectious diseases and cancer, with complex underlying mechanisms. The iNOS/.NO mechanism regulates various cells and tissues that control the anti-tumor T cell response. The concentration and exposure time of .NO can have different effects on immune responses mediated by T cells.
Article
Biotechnology & Applied Microbiology
Shuting Zuo, Zhenyu Wang, Liping Zhao, Jing Wang
Summary: In this study, gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) were constructed to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed excellent effects as a combination therapy for triple-negative breast cancer (TNBC), with high photothermal conversion efficiency and synergistic enhancement of anticancer efficacy through the production of reactive nitrogen species.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Silvia Vivarelli, Luca Falzone, Maria Sofia Basile, Saverio Candido, Massimo Libra
Summary: Recent advances suggest that NO modulation plays a crucial role in the treatment of hematological cancer, either by targeting tumor cells directly or by activating the immune system to eliminate cancer cells. Despite being a dual molecule, NO can be effectively modulated to improve cancer management, particularly in hematological malignancies. This personalized approach is vital for finding eradication therapies for these types of tumors.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
