Article
Multidisciplinary Sciences
Dahoon Park, Yushin Kim
Summary: Recent research has found that inhibiting nerve conduction with a kilohertz frequency through transcutaneous electrical stimulation is effective and safe. This study aimed to demonstrate the hypoalgesic effect of transcutaneous interferential-current nerve inhibition (TINI) on the tibial nerve and compare it with transcutaneous electrical nerve stimulation (TENS) in terms of analgesic effect and comfort. The results showed that TINI significantly increased the pressure pain threshold (PPT) compared to baseline, while TENS did not. Participants also reported TENS to be 36% more uncomfortable than TINI. In conclusion, TINI can inhibit mechanical pain sensitivity effectively and comfortably.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Yi Guo-Sheng, Zhao Qiang, Bai Rui-Feng, Wei Xi-Le, Wang Jiang
Summary: This paper provides a comprehensive review of the preclinical studies on kilohertz frequency alternating current (KHFAC) stimulation for nerve conduction block. It covers various aspects, including the temporal characteristics and methods to reduce onset firing, the duration and underlying mechanisms of poststimulation block, the effects of different stimulus waveform and parameters, the influence of blocking electrode design and position, the potential clinical applications, and the mechanisms involved in KHFAC nerve block. Several key issues for future research are also pointed out.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Chemistry, Analytical
M. Ivette Muzquiz, Landan Mintch, M. Ryne Horn, Awadh Alhawwash, Rizwan Bashirullah, Michael Carr, John H. Schild, Ken Yoshida
Summary: The study successfully demonstrated the high degree of nerve block achieved by LFACb waveform in blocking bradycardic effect induced by vagal stimulation in rats, showing its effectiveness and reversibility.
Article
Neurosciences
Adrien Rapeaux, Timothy G. Constandinou
Summary: This paper describes experiments conducted on rat sciatic nerves to measure the recovery speed of A fibres from block carryover. The findings demonstrate the carryover property of high-frequency nerve block and its potential significance in reducing power requirements for stimulation in clinical applications.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Jochen A. Mosbacher, Stefan Halverscheid, Kolja Pustelnik, Martina Danner, Christina Prassl, Clemens Brunner, Stephan E. Vogel, Michael A. Nitsche, Roland H. Grabner
Summary: The study found that frontal theta band tACS can reduce the repetitions needed to learn new facts, while both frontal and parietal theta band tACS can accelerate the decrease in calculation times in arithmetic learning problems. However, the effects on procedural learning and neurophysiological processes remain unclear.
Article
Medicine, General & Internal
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study investigated the effects of high-frequency alternating currents (HFAC) on the peripheral nervous system in healthy volunteers. The results showed that percutaneous stimulation with 20 kHz HFAC led to a reversible reduction in strength.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Ki Wan Park, Peter Kullar, Charvi Malhotra, Konstantina M. Stankovic
Summary: Chronic subjective tinnitus is a condition where individuals perceive sound without an external source for longer than six months. Current treatments are not very effective, and there is a high demand for new therapies for tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Clemens Neudorfer, T. Clement Chow, Alexandre Boutet, Aaron Loh, Jurgen Germann, Gavin JB. Elias, D. William Hutchison, M. Andres Lozano
Summary: Electrical stimulation in the kilohertz-frequency range elicits diverse effects on neural tissue, distinct from conventional stimulation, including subthreshold, suprathreshold, synaptic, and thermal effects. These effects offer new therapeutic avenues but are associated with unique challenges and caveats that need to be considered in experimental paradigms.
Article
Neurosciences
David Martin-Caro Alvarez, Diego Serrano-Munoz, Juan Jose Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This study evaluated the effect of percutaneous HFAC at 30 kHz on sensory-motor nerve conduction in healthy volunteers. The results showed that the active group had increased pressure pain threshold during and after the stimulation compared to the sham group. Participants in the active group also reported more feelings of numbness and heaviness. No intergroup differences were observed in the remaining outcome variables.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Edgar Pena, Nicole A. Pelot, Warren M. Grill
Summary: Electrical nerve conduction block has the potential to treat diseases by inactivating nerves, but there are obstacles to effective translation. This study evaluated kilohertz-frequency nerve block in rats and found that the lowest frequencies capable of blocking were not the most energy-efficient. Bipolar cuffs required the largest current and power to block, while monopolar and tripolar cuffs required the lowest power. Composite signals combining harmonics at different frequencies were found to reduce block threshold and onset response.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Maren-Christina Blum, Alexander Hunold, Benjamin Solf, Sascha Klee
Summary: Ocular current stimulation (oCS) with weak current intensities has shown positive effects on retinal nerve cells, potentially providing a treatment option for neurodegenerative ocular diseases. Studies indicate that oCS can influence the activity of retinal ganglion cells, with a need for further research into its applications and effects.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
L. Savannah Dewberry, Alexander B. Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J. Hoh, Kyle D. Allen, Kevin J. Otto
Summary: The study showed that HF block can rapidly reduce tactile sensitivity in a limb with neuropathic injury. No significant increase in gait disability was observed during HF block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Kyeong Jae Lee, Byungwook Park, Jae-Won Jang, Sohee Kim
Summary: Magnetic stimulation using small implantable coils and low current is a feasible alternative to transcranial magnetic stimulation (TMS) and electric stimulation with implantable devices. It improves stimulation selectivity and eliminates the need for metal exposure to tissue.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Xiangling Li, Tieyuan Zhang, Chaochao Li, Wenjing Xu, Yanjun Guan, Xiaoya Li, Haofeng Cheng, Shengfeng Chen, Boyao Yang, Yuli Liu, Zhiqi Ren, Xiangyu Song, Zhibo Jia, Yu Wang, Jinshu Tang
Summary: Low-frequency electrical stimulation (ES) promotes nerve regeneration by accelerating Wallerian degeneration (WD) and upregulating the expression of neurotrophic factors, leading to accelerated early axonal and vascular regeneration while delaying muscle atrophy.
Article
Multidisciplinary Sciences
Grant A. McCallum, Xiaohong Sui, Chen Qiu, Joseph Marmerstein, Yang Zheng, Thomas E. Eggers, Chuangang Hu, Liming Dai, Dominique M. Durand
SCIENTIFIC REPORTS
(2017)
Article
Engineering, Biomedical
Narendra Bhadra, Emily Foldes, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Multidisciplinary Sciences
Thomas E. Eggers, Yazan M. Dweiri, Grant A. McCallum, Dominique M. Durand
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Leah Marie Roldan, Thomas E. Eggers, Kevin L. Kilgore, Narendra Bhadra, Tina Vrabec, Niloy Bhadra
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Engineering, Biomedical
Tina L. Vrabec, Jesse S. Wainright, Narendra Bhadra, Laura Shaw, Kevin L. Kilgore, Niloy Bhadra
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2019)
Article
Engineering, Biomedical
T. L. Vrabec, T. E. Eggers, E. L. Foldes, D. M. Ackermann, K. L. Kilgore, N. Bhadra
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2019)
Article
Biochemical Research Methods
N. Bhadra, E. L. Foldes, M. R. Gerges, D. M. Ackermann, N. Bhadra, K. L. Kilgore
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Proceedings Paper
Computer Science, Theory & Methods
Eric R. Cole, Dayton P. Grogan, Thomas E. Eggers, Mark J. Connolly, Nealen G. Laxpati, Robert E. Gross
Summary: In this study, Gaussian process modeling was used to improve data collection procedures in neural modulation by quantifying the uncertainty of standard sampling approaches and selecting samples via active learning. The active learning approach required fewer samples and had uncertainty estimates that converged more closely to the ground-truth error, suggesting Gaussian process modeling can quantitatively enhance data collection procedures in neural modulation.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Eric R. Cole, Mark J. Connolly, Sang-Eon Park, Dayton P. Grogan, William Buxton, Thomas E. Eggers, Nealen G. Laxpati, Robert E. Gross
Summary: The study found that the effect of neural modulation on neural activity differs between awake and anesthetized states. To address this issue, a novel Bayesian optimization method was introduced to efficiently explore complex state-dependent relationships.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
Proceedings Paper
Engineering, Biomedical
Tina L. Vrabec, Kevin L. Kilgore, Jesse S. Wainright, Niloy Bhadra
2019 9TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2019)