Article
Endocrinology & Metabolism
Konica Porwal, Shivani Sharma, Saroj Kumar, Manendra Singh Tomar, Sreyanko Sadhukhan, Swati Rajput, Chirag Kulkarni, Ashutosh Shrivastava, Navin Kumar, Naibedya Chattopadhyay
Summary: We investigated the effects of hormonal and non-hormonal oral contraceptives on bone mass, mineralization, composition, mechanical properties, and metabolites in pubertal female rats. Both types of contraceptives had adverse effects on various skeletal parameters, with the hormonal contraceptive having a greater negative impact on bone strength. Overall, the study highlights the importance of considering the effects of oral contraceptives on bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Materials Science, Biomaterials
Nahida Rasool, Deepa Negi, Yashveer Singh
Summary: Osteoporosis is a chronic bone disorder characterized by decreased bone mass and increased fracture risk. This study developed thiolated, bioactive mesoporous silica nanoparticles (MSN-SH) with antioxidant and regenerative properties for potential treatment of osteoporosis. MSN-SH exhibited high antioxidant activity, protected cells from reactive oxygen species-induced damage, and induced osteogenesis. It also inhibited osteoclastogenesis, promoted migration of osteoblast cells, and showed potential as a complementary treatment for osteoporosis. The surface modification of MSN-SH offers a simple and economical method to enhance its properties and introduce new activities.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Agriculture, Multidisciplinary
Gong-Jhe Wu, Kung-Yen Chen, Jr-Di Yang, Shing-Hwa Liu, Ruei-Ming Chen
Summary: The study showed that naringin, a citrus flavonoid, can enhance bone mineralization and healing in osteoporosis-related bone diseases by activating ERα and ALP expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Alexander N. Comninos, Morten S. Hansen, Alan Courtney, Sirazum Choudhury, Lisa Yang, Edouard G. Mills, Maria Phylactou, Mark Busbridge, Muaza Khir, Thilipan Thaventhiran, Paul Bech, Tricia Tan, Ali Abbara, Morten Frost, Waljit S. Dhillo
Summary: This study aims to assess the effects of kisspeptin on human bone metabolism. In vitro experiments showed that kisspeptin promoted osteoblast differentiation and inhibited osteoclastic resorptive activity. Clinical experiments showed that kisspeptin increased bone formation markers without affecting bone resorption markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Hui-Yuan Shih, Jun-Hua Lu, Ai-Hua Xiong, Juliana Man-Wai Tse, Ben Siu-Tak Wong
Summary: This study investigated the effects of the natural plant extract, SDTL-E, in ovariectomized-induced osteoporosis rats. The results showed that 20 days of SDTL-E topical treatment improved bone strength and trabecular bone structure. These findings suggest that topical application of plant extract is a potential new approach for treating osteoporosis.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Tanju Celik, Ozlem Sangun, Sule Unal, Ali Balci, Sedat Motor
Summary: The study suggests that serum OPG concentration can be used as a biochemical marker for screening the development of osteoporosis in patients with beta-thalassemia major.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Cell Biology
Xiaofang Zhu, Xiangfen Li, Xiaoxuan Wang, Ting Chen, Fengjuan Tao, Chuanju Liu, Qisheng Tu, Guofang Shen, Jake J. Chen
Summary: Research indicates that irisin plays a crucial role in bone metabolism and in the cross-talk between bone and adipose tissue. Absence of irisin results in decreased bone density, delayed bone development and mineralization, as well as weakening of positive effects of exercise on bone strength and weight loss. Supplementation with recombinant irisin during exercise can rescue these effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Plant Sciences
Reena Rai, Sudhir Kumar, Krishna Bhan Singh, Sonu Khanka, Yatendra Singh, K. R. Arya, Sanjeev Kanojiya, Rakesh Maurya, Divya Singh
Summary: The ethanolic extract and butanolic fraction of Musa paradisiaca flower show potential in preventing bone density loss and promoting bone regeneration, improving bone microarchitecture in postmenopausal conditions. Compounds isolated from the extract exhibit significant osteogenic effects.
Review
Biochemistry & Molecular Biology
Iswari Davan, Sharida Fakurazi, Ekram Alias, Nurul Izzah Ibrahim, Ng Min Hwei, Haniza Hassan
Summary: In recent years, bone loss and its associated diseases have become a significant public health concern. Oxidative stress, which suppresses osteoblast activity, is correlated with bone loss. Supplementation of antioxidants, such as astaxanthin, could reduce oxidative stress and improve bone health.
Review
Immunology
Anja Saalbach, Manfred Kunz
Summary: Psoriasis is a chronic inflammatory disease associated with various comorbidities and has been linked to cardiovascular diseases. However, recent evidence suggests that it also impacts the development of osteoporosis. Routine bone metabolism examination is crucial for psoriatic patients to prevent long-term consequences.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Vania P. Roberto, Gwladys Surget, Klervi Le Lann, Sara Mira, Marco Tarasco, Fabienne Guerard, Nathalie Poupart, Vincent Laize, Valerie Stiger-Pouvreau, M. Leonor Cancela
Summary: The study found that the ethyl acetate fraction rich in polyphenols from Spartina alterniflora has significant antioxidant and bone anabolic activities, potentially serving as a novel source for therapeutic applications in bone disorders.
FRONTIERS IN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Kyung-Ran Park, Jae-Il Park, Seongsoo Lee, Kyeongwon Yoo, Gi-Ryang Kweon, Il Keun Kwon, Hyung-Mun Yun, Jin Tae Hong
Summary: This study demonstrates that Chi3L1 promotes bone formation by enhancing BMP2 signaling and suppressing osteoclastogenesis. It also prevents aging-related osteoporosis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Zhenen Lin, Guanshu Yu, Shengren Xiong, Yu Lin, Zhaohui Li
Summary: The purpose of this study was to investigate the effects of leptin and melatonin on bone metabolism in ovariectomized rodents and their potential mechanisms. The results showed that leptin and melatonin can improve trabecular microstructure, enhance bone growth, reduce trabecular damage, and promote bone repair in rats with osteoporosis. The combined effect of the two is more significant.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Wacili Da, Lin Tao, Yue Zhu
Summary: In recent years, research on the mechanism underlying bone metabolic disorders based on energy metabolism has made significant progress, focusing on the impact of osteoclast energy metabolism disorder on bone homeostasis and proposing a compensatory recovery mechanism as a new approach for the treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Ganchimeg Davaa, Jin Young Hong, Jung-Hwan Lee, Min Soo Kim, Jennifer O. Buitrago, Yu-Meng Li, Hae-Hyoung Lee, Dong Wook Han, Kam W. Leong, Jung Keun Hyun, Hae-Won Kim
Summary: Neural stem cells (NSC) have the potential to regenerate injured neural tissues, but suffer from low survival and uncontrolled differentiation. This study demonstrates that mechanically-tuned protein hydrogels can protect and enhance the long-term survival of reprogrammed NSC, alleviate neural inflammation, promote differentiation, and improve locomotor functions in treating injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Seon Yeong Chae, Sangheon Jeon, Dong-Wook Han, Suck Won Hong
Summary: Researchers have investigated the excellent antibacterial activity of graphene-based materials, which utilize the unique mechanical, electrical, and surface properties of graphene, to address the challenges of bacterial drug resistance and emerging infectious diseases. The antibacterial mechanism involves physical damage and chemical interactions between graphene and bacterial membranes. A simple manufacturing process was also developed to create three-dimensionally arranged graphene oxide films, which exhibited antibacterial activity.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Review
Biochemistry & Molecular Biology
Moon Sung Kang, Jinju Jang, Hyo Jung Jo, Won-Hyeon Kim, Bongju Kim, Heoung-Jae Chun, Dohyung Lim, Dong-Wook Han
Summary: This review focuses on the advances and innovations of 3D bioprinted skin for skin regeneration. By improving materials, structures, and functions, the clinical potential of 3D bioprinted skin has been enhanced. With state-of-the-art printing technology and novel biomaterials, highly developed skin comprising stratified epidermis, dermis, and hypodermis with blood vessels, nerves, muscles, and skin appendages can be fabricated. We hope that this review will guide future research and clinical applications.
Article
Nanoscience & Nanotechnology
Sangmun Choi, Iruthayapandi Selestin Raja, Aravindha Raja Selvaraj, Moon Sung Kang, Tae-Eon Park, Ki Su Kim, Suong-Hyu Hyon, Dong-Wook Han, Jong-Chul Park
Summary: Carbon nanotubes are commonly used one-dimensional carbonaceous nanomaterials in tissue engineering, while other forms of one-dimensional nanomaterials, such as carbon nanowires and carbon nanofibers, have not been extensively explored for biomedical applications. In this study, activated carbon nanofiber nanoparticles (ACNF NPs) were synthesized from polyacrylonitrile electrospun nanofibers. Two different types of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats were prepared and evaluated for their potential as skin tissue engineering scaffolds. The results showed that ACNF NPs exhibited a graphitization degree with an I-D/I-G ratio of 1.05, and had a diameter of 280 +/- 100 nm and a length of 565-3322 nm. NPs with a concentration above 30 μg/mL exhibited toxicity to NIH3T3 fibroblasts. The ACNF-PCL nanofiber mats demonstrated better cell proliferation compared to PCL and ACNF@PCL mats. Therefore, it can be concluded that ACNF-PCL mats with a lower concentration of ACNF NPs have greater potential to support cellular growth and impact skin tissue regeneration.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Review
Engineering, Biomedical
Iruthayapandi Selestin Raja, Moon Sung Kang, Suck Won Hong, Hojae Bae, Bongju Kim, Yu-Shik Hwang, Jae Min Cha, Dong-Wook Han
Summary: Biofabrication approaches, such as 3D bioprinting of hydrogels, have gained increasing attention for their ability to construct complex 3D tissue and organ structures. However, the stability and shape fidelity of printed gels can be affected by various factors. To address this, researchers have incorporated different nanomaterials into polymeric hydrogels. This review discusses CFNs-containing printable gels in various biomedical applications, including the types of bioprinters, prerequisites of bioink and biomaterial ink, and the progress and challenges in this field.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Chemistry, Multidisciplinary
Indong Jun, Hyunki Cho, Sebastian E. Amos, Youngjun Choi, Yu Suk Choi, Chang Seon Ryu, Sang-Ah Lee, Dong-Wook Han, Hyung-Seop Han, Ji Hun Yang, Hyun-Woo Jeong, Honghyun Park, Young Jun Kim
Summary: The disruption of thyroid hormones due to chemical exposure is a significant societal problem. Recent breakthroughs in biotechnology have allowed for the evaluation of potential toxicity of chemicals using 3D cell cultures. This study focuses on the interactive effects of thyroid-friendly soft (TS) microspheres on thyroid cell aggregates and evaluates their potential as a reliable toxicity assessment tool.
Article
Polymer Science
Soloman Agnes Mary, Naisini Ariram, Arun Gopinath, Senthil Kumar Chinnaiyan, Iruthayapandi Selestin Raja, Bindia Sahu, Venkateshwarapuram Rengaswami Giri Dev, Dong-Wook Han, Balaraman Madhan
Summary: In this study, a fibrous mat incorporating the bioactive extract of Cassia auriculata (CA) with polycaprolactone (PCL) was developed using the centrifugal spinning technique. The concentration of PCL and the spinning speed were optimized to achieve better fiber formation. The developed fibrous mat showed fine pores and high biocompatibility for cell proliferation.
Article
Cell Biology
Moon Sung Kang, Rowoon Park, Hyo Jung Jo, Yong Cheol Shin, Chang-Seok Kim, Suong-Hyu Hyon, Suck Won Hong, Junghwan Oh, Dong-Wook Han
Summary: In recent years, bone tissue engineering has made significant progress in promoting the direct and functional connection between bone and graft to facilitate the healing of damaged bone tissues. This study introduces a new method for synthesizing reduced graphene oxide (rGO) and hydroxyapatite (HAp) using environmentally friendly materials. The synthesized E-rGO/HAp composites showed exceptional properties for use as bone tissue engineering scaffolds and promoted the proliferation and osteogenic differentiation of human mesenchymal stem cells. These composites have the potential to be used as BTE scaffolds, stem-cell differentiation stimulators, and implantable device components due to their biocompatible and bioactive properties.
Article
Biochemistry & Molecular Biology
Gyeonghyeon Kim, Dong-Wook Han, Jong Hun Lee
Summary: In this study, baicalein was found to have antioxidant effects and could protect HaCaT keratinocytes from H2O2-induced oxidative stress by maintaining mitochondrial homeostasis and cellular tight junctions.
Article
Multidisciplinary Sciences
Seok Hyun Lee, Moon Sung Kang, Sangheon Jeon, Hyo Jung Jo, Suck Won Hong, Bongju Kim, Dong-Wook Han
Summary: Contemporary advances in 3D bioprinting have allowed for the creation of personalized live 3D tissue mimetics. The development of bioink materials that accurately replicate the composition of native extracellular matrix and mimic cell properties has been emphasized. In this study, MXene-incorporated GelMA/HAMA bioinks were prepared to investigate their potential for spontaneous osteodifferentiation of human mesenchymal stem cells (hMSCs) when used for 3D printing. The GelMA/HAMA-MXene hydrogels were found to provide favorable matrices for hMSCs growth and survival, and hMSCs were shown to differentiate into osteoblasts in the GelMA-HAMA/MXene composites, creating a favorable microenvironment for bone regeneration. These findings suggest that MXene-incorporated GelMA/HAMA bioink has significant biofunctional advantages for the development of effective scaffolds in bone tissue regeneration.
Article
Chemistry, Multidisciplinary
Hee Jeong Jang, Moon Sung Kang, Won-Hyeon Kim, Hyo Jung Jo, Sung-Ho Lee, Eun Jeong Hahm, Jung Hyun Oh, Suck Won Hong, Bongju Kim, Dong-Wook Han
Summary: We used 3D printing to fabricate graphene oxide (GO)-incorporated polylactic acid (PLA) films and explored their benefits as barrier membranes in guided bone regeneration (GBR). Our results showed that the 3D printed GO-PLA films provided a favorable environment for preosteoblasts and promoted new bone formation in rat calvarial bone defect models.
NANOSCALE ADVANCES
(2023)
Article
Orthopedics
Dae-Kyung Kwak, Ji-Eun Jang, Won-Hyeon Kim, Sung -Jae Lee, Yongmin Lee, Je-Hyun Yoo
Summary: This study compared the mechanical characteristics of four fixation methods for anterior column-posterior hemitransverse acetabular fractures typical in elderly patients. The anatomical suprapectineal QLS plate showed higher structural stiffness and lower displacement compared to other fixations.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
