Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

(2019) Rongkun Li et al.   Molecular Cancer

Lysyl oxidase-like 2 (LOXL2) depletion is protective in age-associated vascular stiffening

(2019) Jochen Steppan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Induction of LOX by TGF‐β1/Smad/AP‐1 signaling aggravates rat myocardial fibrosis and heart failure

(2019) Min Lu et al.   IUBMB LIFE

Inhibition of enzymes involved in collagen cross-linking reduces vascular smooth muscle cell calcification

(2018) Eva Jover et al.   FASEB JOURNAL

LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy

(2018) Leonie Rossow et al.   ONCOGENE

Preliminary analysis of proteome alterations in non-aneurysmal, internal mammary artery tissue from patients with abdominal aortic aneurysms

(2018) Christina Lund Kidholm et al.   PLoS One

Inhibition of angiogenesis in endothelial cells by Human Lysyl oxidase propeptide

(2018) Ragavachetty Nagaraj Nareshkumar et al.   Scientific Reports

Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity

(2018) Saray Varona et al.   Scientific Reports

Is This the Last Requiem for Simtuzumab?

(2018) Peter Fickert   HEPATOLOGY

Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition

(2018) Olivier G. de Jong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II–induced hypertrophy

(2017) María Galán et al.   FASEB JOURNAL

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

(2017) Martin W. Rowbottom et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase

(2017) Yang Yu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

(2017) Joan Chang et al.   Oncotarget

Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

(2017) José Luis Miguel-Carrasco et al.   Scientific Reports

Lysyl oxidase is associated with increased thrombosis and platelet reactivity

(2016) S. Matsuura et al.   BLOOD

LOXMutations Predispose to Thoracic Aortic Aneurysms and DissectionsNovelty and Significance

(2016) Dong-chuan Guo et al.   CIRCULATION RESEARCH

Mechanical control of cardiac myofibroblasts

(2016) Sander van Putten et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats

(2016) Ernesto Martínez-Martínez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of function mutation inLOXcauses thoracic aortic aneurysm and dissection in humans

(2016) Vivian S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

(2016) Jin Yang et al.   Nature Communications

Calcific Aortic Valve Disease Is Associated with Layer-Specific Alterations in Collagen Architecture

(2016) Heather N. Hutson et al.   PLoS One

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

(2015) José González-Santamaría et al.   CARDIOVASCULAR RESEARCH

Advanced glycation end products upregulate lysyl oxidase and endothelin-1 in human aortic endothelial cells via parallel activation of ERK1/2–NF-κB and JNK–AP-1 signaling pathways

(2015) Christos Adamopoulos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression

(2015) A. Martin et al.   EMBO JOURNAL

Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice

(2015) Jian Zhang et al.   HUMAN MOLECULAR GENETICS

Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome

(2015) O. Busnadiego et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of Lysyl Oxidase Inhibition on Angiotensin II-Induced Arterial Hypertension, Remodeling, and Stiffness

(2015) Lance S. Eberson et al.   PLoS One

Lysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension

(2014) A. H. Nave et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysyl oxidase (LOX) in vascular remodelling: insight from a new animal model

(2014) M. Orriols et al.   ATHEROSCLEROSIS

Lysine post-translational modifications of collagen

(2014) Mitsuo Yamauchi et al.   Essays in Biochemistry

Arterial Stiffness and Hypertension

(2014) Gary F. Mitchell   HYPERTENSION

The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions

(2014) O. A. Ovchinnikova et al.   JOURNAL OF INTERNAL MEDICINE

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis

(2013) T Osawa et al.   BRITISH JOURNAL OF CANCER

Lysyl oxidase-like-2 promotes tumour angiogenesis and is a potential therapeutic target in angiogenic tumours

(2013) Shelly Zaffryar-Eilot et al.   CARCINOGENESIS

Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?

(2013) Begoña López et al.   CARDIOVASCULAR RESEARCH

LOXL4 Is Induced by Transforming Growth Factor  1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

(2013) O. Busnadiego et al.   MOLECULAR AND CELLULAR BIOLOGY

Left and Right Ventricle Late Remodeling Following Myocardial Infarction in Rats

(2013) Ivanita Stefanon et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms

(2012) Ebony Washington Remus et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis

(2012) A.-M. Baker et al.   CANCER RESEARCH

Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure

(2012) Begoña López et al.   HYPERTENSION

Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening

(2012) Devashish Kothapalli et al.   Cell Reports

TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways

(2011) Tetyana G. Voloshenyuk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

(2011) M. Bignon et al.   BLOOD

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

(2011) Tetyana G. Voloshenyuk et al.   CYTOKINE

Added value of CAC in risk stratification for cardiovascular events: a systematic review

(2011) Sanne A. E. Peters et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction

(2011) Mario Kasner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PDGF-BB and TGF-β1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress

(2011) Ying-Xin Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular lysyl oxidase: Effect of a specific inhibitor on nuclear mass in proliferating cells

(2010) Fawzy A. Saad et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

(2010) Hongyu Qiu et al.   CIRCULATION RESEARCH

Homocysteine Suppresses the Expression of the Collagen Cross-linker Lysyl Oxidase Involving IL-6,Fli1, and Epigenetic DNA Methylation

(2010) Roman Thaler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-lymphocytes mediate left ventricular fibrillar collagen cross-linking and diastolic dysfunction in mice

(2010) Qianli Yu et al.   MATRIX BIOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Pathophysiology and epidemiology of abdominal aortic aneurysms

(2010) Ian M. Nordon et al.   Nature Reviews Cardiology

T-Cell Activation Leads to Reduced Collagen Maturation in Atherosclerotic Plaques of Apoe−/− Mice

(2009) Olga Ovchinnikova et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm

(2009) Tomohiro Aoki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Osteoprotegerin Promotes Fibrous Cap Formation in Atherosclerotic Lesions of ApoE-Deficient Mice—Brief Report

(2009) Olga Ovchinnikova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm

(2009) Masahiko Onoda et al.   ATHEROSCLEROSIS

Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors

(2009) Cristina Rodríguez et al.   CARDIOVASCULAR RESEARCH

Lysyl oxidase as a potential therapeutic target

(2009) C. Rodríguez et al.   DRUG NEWS & PERSPECTIVES

Collagen Cross-Linking Influences Osteoblastic Differentiation

(2008) C. Turecek et al.   CALCIFIED TISSUE INTERNATIONAL

Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases

(2008) C. Rodriguez et al.   CARDIOVASCULAR RESEARCH

Impact of Treatment on Myocardial Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure

(2008) Begoña López et al.   HYPERTENSION

Lysyl Oxidase Binds Transforming Growth Factor-β and Regulates Its Signaling via Amine Oxidase Activity

(2008) Phimon Atsawasuwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysyl Oxidase Oxidizes Cell Membrane Proteins and Enhances the Chemotactic Response of Vascular Smooth Muscle Cells

(2008) Héctor A. Lucero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups

(2008) Robert Detrano et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lysyl oxidase (LOX) down-regulation by TNFα: A new mechanism underlying TNFα-induced endothelial dysfunction

(2007) C. Rodríguez et al.   ATHEROSCLEROSIS

Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation

(2007) Paola A. Hurtado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS