Efficient Delivery of Dengue Virus Subunit Vaccines to the Skin by Microprojection Arrays

Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

(2019) Hwee-Ing Ng et al.   npj Vaccines

Structural and Functional Characterization of a Cross-Reactive Dengue Virus Neutralizing Antibody that Recognizes a Cryptic Epitope

(2018) Jie Li et al.   STRUCTURE

Antibody Epitopes Identified in Critical Regions of Dengue Virus Nonstructural 1 Protein in Mouse Vaccination and Natural Human Infections

(2017) Tomer Hertz et al.   JOURNAL OF IMMUNOLOGY

High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses

(2017) David A. Muller et al.   Scientific Reports

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

(2016) Arnaud M. Didierlaurent et al.   Expert Review of Vaccines

Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment

(2016) Neil M. Ferguson et al.   SCIENCE

A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates

(2016) Gokul Swaminathan et al.   Scientific Reports

Potent response of QS-21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing

(2016) Hwee-Ing Ng et al.   Scientific Reports

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

(2016) Daniel Watterson et al.   Scientific Reports

The changing shape of vaccination: improving immune responses through geometrical variations of a microdevice for immunization

(2016) Michael Lawrence Crichton et al.   Scientific Reports

Dengue infection

(2016) Maria G. Guzman et al.   Nature Reviews Disease Primers

Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses

(2016) David A. Muller et al.   Scientific Reports

Preclinical development of a dengue tetravalent recombinant subunit vaccine: Immunogenicity and protective efficacy in nonhuman primates

(2015) Dhanasekaran Govindarajan et al.   VACCINE

Functional anti-polysaccharide IgG titres induced by unadjuvanted pneumococcal-conjugate vaccine when delivered by microprojection-based skin patch

(2015) Frances E. Pearson et al.   VACCINE

Mouse models of dengue virus infection for vaccine testing

(2015) Vanessa V. Sarathy et al.   VACCINE

Colocalization of Cell Death with Antigen Deposition in Skin Enhances Vaccine Immunogenicity

(2014) Alexandra C.I. Depelsenaire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Safety, immunogenicity and efficacy of a recombinant tetravalent dengue vaccine: A meta-analysis of randomized trials

(2014) Vivaldo G. da Costa et al.   VACCINE

Mouse Models to Study Dengue Virus Immunology and Pathogenesis

(2014) Raphaël M. Zellweger et al.   Frontiers in Immunology

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

(2013) Frances E. Pearson et al.   PLoS One

Surface Modified Microprojection Arrays for the Selective Extraction of the Dengue Virus NS1 Protein As a Marker for Disease

(2012) David A. Muller et al.   ANALYTICAL CHEMISTRY

Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

(2012) Germain J.P. Fernando et al.   JOURNAL OF CONTROLLED RELEASE

High density and high aspect ratio solid micro-nanoprojection arrays for targeted skin vaccine delivery and specific antibody extraction

(2012) Derek Jenkins et al.   RSC Advances

Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

(2011) Xianfeng Chen et al.   JOURNAL OF CONTROLLED RELEASE

The development of recombinant subunit envelope-based vaccines to protect against dengue virus induced disease

(2011) Beth-Ann G. Coller et al.   VACCINE

Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice

(2011) Joseph N. Brewoo et al.   VACCINE

The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine

(2010) Michael L. Crichton et al.   BIOMATERIALS

Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays

(2010) Xianfeng Chen et al.   JOURNAL OF CONTROLLED RELEASE

Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse Model

(2010) Germain J. P. Fernando et al.   PLoS One

Skin Vaccination against Cervical Cancer Associated Human Papillomavirus with a Novel Micro-Projection Array in a Mouse Model

(2010) Holly J. Corbett et al.   PLoS One

Nanopatch-Targeted Skin Vaccination against West Nile Virus and Chikungunya Virus in Mice

(2010) Tarl W. Prow et al.   Small

Development of a recombinant tetravalent dengue virus vaccine: Immunogenicity and efficacy studies in mice and monkeys

(2010) David E. Clements et al.   VACCINE