Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)

(2018) Germain J.P. Fernando et al.   VACCINE

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial

(2017) Nadine G Rouphael et al.   LANCET

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

(2017) Dmitri Kazmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans

(2017) Jonathan C. J. Wei et al.   Scientific Reports

Microneedle patches for vaccination in developing countries

(2016) Jaya Arya et al.   JOURNAL OF CONTROLLED RELEASE

Microneedles: A New Frontier in Nanomedicine Delivery

(2016) Eneko Larrañeta et al.   PHARMACEUTICAL RESEARCH

The success of microneedle-mediated vaccine delivery into skin

(2016) Sarah Marshall et al.   Human Vaccines & Immunotherapeutics

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adjuvant effect of low frequency ultrasound when applied with an inactivated Aeromonas salmonicida vaccine to rainbow trout (Oncorhynchus mykiss)

(2015) Cristóbal Cobo Labarca et al.   VACCINE

Recent insights into cutaneous immunization: How to vaccinate via the skin

(2015) Laura Engelke et al.   VACCINE

Colocalization of Cell Death with Antigen Deposition in Skin Enhances Vaccine Immunogenicity

(2014) Alexandra C.I. Depelsenaire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A micro-sterile inflammation array as an adjuvant for influenza vaccines

(2014) Ji Wang et al.   Nature Communications

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Host Responses in Human Skin After Conventional Intradermal Injection or Microneedle Administration of Virus-Like-Particle Influenza Vaccine

(2013) Marc Pearton et al.   Advanced Healthcare Materials

Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

(2012) Germain J.P. Fernando et al.   JOURNAL OF CONTROLLED RELEASE

Induction of potent CD8+ T cell responses through the delivery of subunit protein vaccines to skin antigen-presenting cells using densely packed microprojection arrays

(2012) Hwee-Ing Ng et al.   JOURNAL OF CONTROLLED RELEASE

Transcutaneous vaccination via laser microporation

(2012) Richard Weiss et al.   JOURNAL OF CONTROLLED RELEASE

MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

(2012) E. Caproni et al.   JOURNAL OF IMMUNOLOGY

High density and high aspect ratio solid micro-nanoprojection arrays for targeted skin vaccine delivery and specific antibody extraction

(2012) Derek Jenkins et al.   RSC Advances

Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection

(2012) Dimitrios G. Koutsonanos et al.   Scientific Reports

The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers

(2011) Michael L. Crichton et al.   BIOMATERIALS

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

Laser vaccine adjuvant for cutaneous immunization

(2011) Xinyuan Chen et al.   Expert Review of Vaccines

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle

(2011) Feng Lin et al.   VACCINE

The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine

(2010) Michael L. Crichton et al.   BIOMATERIALS

One does not fit all: new adjuvants are needed and vaccine formulation is critical

(2010) Karen Smith Korsholm   Expert Review of Vaccines

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

ConsensusPathDB: toward a more complete picture of cell biology

(2010) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse Model

(2010) Germain J. P. Fernando et al.   PLoS One

A Novel Laser Vaccine Adjuvant Increases the Motility of Antigen Presenting Cells

(2010) Xinyuan Chen et al.   PLoS One

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Increased subcutaneous adipose tissue impairs dermal function in diet-induced obese mice

(2009) Tomonobu Ezure et al.   EXPERIMENTAL DERMATOLOGY

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

(2009) Suzanne Jones et al.   VACCINE

Low-frequency sonophoresis: Current status and future prospects

(2008) Makoto Ogura et al.   ADVANCED DRUG DELIVERY REVIEWS

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Molecular and cellular signatures of human vaccine adjuvants

(2008) F. Mosca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA