The Chromatin Remodeler Brg1 Integrates ROS Production and Endothelial-Mesenchymal Transition to Promote Liver Fibrosis in Mice

Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1

(2019) Xinyu Weng et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The chromatin remodeling protein BRM regulates the transcription of tight junction proteins: Implication in breast cancer metastasis

(2019) Yuyu Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A non-autonomous role of MKL1 in the activation of hepatic stellate cells

(2019) Zilong Li et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A crosstalk between BRG1 and MOF contributes to ROS production in a mouse model of non-alcoholic steatohepatitis

(2018) Li Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes

(2018) Nan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway

(2018) Yuyu Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production

(2018) Li Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Megakaryocytic Leukemia 1 (MKL1) Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury

(2018) Yu Liming et al.   CIRCULATION

Brahma related gene 1 (Brg1) contributes to liver regeneration by epigenetically activating the Wnt/β-catenin pathway in mice

(2018) Nan Li et al.   FASEB JOURNAL

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

(2018) Min Li et al.   FASEB JOURNAL

KDM4B protects against obesity and metabolic dysfunction

(2018) Yingduan Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells

(2018) Zilong Li et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury

(2018) Zilong Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte

(2018) Nan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities

(2018) Changkeun Kang et al.   GENES TO CELLS

Brg1 deficiency in vascular endothelial cells blocks neutrophil recruitment and ameliorates cardiac ischemia-reperfusion injury in mice

(2018) Xinjian Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

(2018) Li-Yu Huang et al.   Nature Communications

A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis

(2018) Duong Thi Bich Thuan et al.   Frontiers in Immunology

Angiotensin II induced CSF1 transcription is mediated by a crosstalk between different epigenetic factors in vascular endothelial cells

(2018) Jing Shao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Brg1 trans-activates endothelium-derived colony stimulating factor to promote calcium chloride induced abdominal aortic aneurysm in mice

(2018) Xinjian Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity

(2017) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

The origin of fibrogenic myofibroblasts in fibrotic liver

(2017) Tatiana Kisseleva   HEPATOLOGY

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases

(2017) Evangelia Pardali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease

(2017) Joaquim Miguel Vieira et al.   Nature Communications

Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53

(2017) Howard E. Boudreau et al.   Oncotarget

An optimized method for mouse liver sinusoidal endothelial cell isolation

(2016) Jeremy Meyer et al.   EXPERIMENTAL CELL RESEARCH

KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer

(2016) Haijie Li et al.   Oncotarget

Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence

(2015) Yan Y. Sanders et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

SWI/SNF Chromatin-Remodeling Enzymes Brahma-Related Gene 1 (BRG1) and Brahma (BRM) Are Dispensable in Multiple Models of Postnatal Angiogenesis But Are Required for Vascular Integrity in Infant Mice

(2015) M. M. Wiley et al.   Journal of the American Heart Association

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β

(2014) Guangxing Bai et al.   GENE

Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer

(2014) Bei Bei Sun et al.   Journal of Digestive Diseases

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch

(2014) F Yan et al.   Cell Death & Disease

BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development

(2013) R. B. Davis et al.   DEVELOPMENT

Reactive Oxygen Species in Vascular Formation and Development

(2013) Yijiang Zhou et al.   Oxidative Medicine and Cellular Longevity

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels

(2011) C. T. Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

(2010) E Sánchez-Tilló et al.   ONCOGENE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

(2008) Kryn Stankunas et al.   DEVELOPMENTAL CELL

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development

(2007) C. T. Griffin et al.   DEVELOPMENT

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY