Assessing Affective State in Laboratory Rodents to Promote Animal Welfare—What Is the Progress in Applied Refinement Research?

What do animals want?

(2019) B Franks   ANIMAL WELFARE

DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations

(2019) Kevin R. Coffey et al.   NEUROPSYCHOPHARMACOLOGY

Evaluating analgesic efficacy and administration route following craniotomy in mice using the grimace scale

(2019) Chulmin Cho et al.   Scientific Reports

Towards large scale automated cage monitoring – Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique

(2019) Karin Pernold et al.   PLoS One

Burrowing and nest building activity in mice after exposure to grid floor, isoflurane or ip injections

(2019) Karen Gjendal et al.   PHYSIOLOGY & BEHAVIOR

Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model

(2019) Paulin Jirkof et al.   Scientific Reports

Behavioral and neural correlates of hide-and-seek in rats

(2019) Annika Stefanie Reinhold et al.   SCIENCE

Improvement of the Mouse Grimace Scale set-up for implementing a semi-automated Mouse Grimace Scale scoring (Part 1)

(2019) Lisa Ernst et al.   LABORATORY ANIMALS

Small Animal Video Tracking for Activity and Path Analysis Using a Novel Open-Source Multi-Platform Application (AnimApp)

(2019) Srinivasa R. Rao et al.   Scientific Reports

What Is so Positive about Positive Animal Welfare?—A Critical Review of the Literature

(2019) Alistair B. Lawrence et al.   Animals

Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling

(2018) Christina Möller et al.   EPILEPSIA

Individualized tracking of self-directed motor learning in group-housed mice performing a skilled lever positioning task in the home cage

(2018) Gergely Silasi et al.   JOURNAL OF NEUROPHYSIOLOGY

A deep neural network to assess spontaneous pain from mouse facial expressions

(2018) Alexander H Tuttle et al.   Molecular Pain

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

(2018) Katharina Hohlbaum et al.   Jove-Journal of Visualized Experiments

Can grimace scales estimate the pain status in horses and mice? A statistical approach to identify a classifier

(2018) Emanuela Dalla Costa et al.   PLoS One

Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?

(2018) Nicole Marquardt et al.   PLoS One

Running in the wheel: Defining individual severity levels in mice

(2018) Christine Häger et al.   PLOS BIOLOGY

Wanting, liking and welfare: The role of affective states in proximate control of behaviour in vertebrates

(2017) Lorenz Gygax   ETHOLOGY

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

(2017) Katharina Hohlbaum et al.   PLoS One

Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

(2017) Jereme G. Spiers et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Introducing Clicker Training as a Cognitive Enrichment for Laboratory Mice

(2017) Charlotte Leidinger et al.   Jove-Journal of Visualized Experiments

Rat tickling: A systematic review of applications, outcomes, and moderators

(2017) Megan R. LaFollette et al.   PLoS One

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

(2017) William S. Redfern et al.   PLoS One

Play and optimal welfare: Does play indicate the presence of positive affective states?

(2017) Jamie Ahloy-Dallaire et al.   BEHAVIOURAL PROCESSES

Play matters: the surprising relationship between juvenile playfulness and anxiety in later life

(2016) S. Helene Richter et al.   ANIMAL BEHAVIOUR

Pharmacological characterization of intraplantar Complete Freund’s Adjuvant-induced burrowing deficits

(2016) Stacey Anne Gould et al.   BEHAVIOURAL BRAIN RESEARCH

Preliminary Evidence of Apathetic-Like Behavior in Aged Vesicular Monoamine Transporter 2 Deficient Mice

(2016) Aron Baumann et al.   Frontiers in Human Neuroscience

Score sheets and analgesia

(2016) Huw Golledge et al.   LABORATORY ANIMALS

The neurobiology of social play and its rewarding value in rats

(2016) Louk J.M.J. Vanderschuren et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Establishment of Early Endpoints in Mouse Total-Body Irradiation Model

(2016) Amory Koch et al.   PLoS One

Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats

(2016) Vivian Leung et al.   Scientific Reports

M-Track: A New Software for Automated Detection of Grooming Trajectories in Mice

(2016) Sheldon L. Reeves et al.   PLoS Computational Biology

Moving beyond the “Five Freedoms” by Updating the “Five Provisions” and Introducing Aligned “Animal Welfare Aims”

(2016) David Mellor   Animals

Facial Indicators of Positive Emotions in Rats

(2016) Kathryn Finlayson et al.   PLoS One

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

(2015) Kiterie M. E. Faller et al.   EXPERIMENTAL PHYSIOLOGY

Neurobiology of rodent self-grooming and its value for translational neuroscience

(2015) Allan V. Kalueff et al.   NATURE REVIEWS NEUROSCIENCE

Mapping Sub-Second Structure in Mouse Behavior

(2015) Alexander B. Wiltschko et al.   NEURON

Association between exploratory activity and social individuality in genetically identical mice living in the same enriched environment

(2015) J. Freund et al.   NEUROSCIENCE

Time to Integrate to Nest Test Evaluation in a Mouse DSS-Colitis Model

(2015) Christine Häger et al.   PLoS One

Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning

(2015) Weizhe Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Burrowing and nest building behavior as indicators of well-being in mice

(2014) Paulin Jirkof   JOURNAL OF NEUROSCIENCE METHODS

Effect of multilevel laboratory rat caging system on the well-being of the singly-housed Sprague Dawley rat

(2014) R R Wheeler et al.   LABORATORY ANIMALS

Oral self-administration of buprenorphine in the diet for analgesia in mice

(2014) M J Molina-Cimadevila et al.   LABORATORY ANIMALS

The applicability of a gel delivery system for self-administration of buprenorphine to laboratory mice

(2014) AMB Hovard et al.   LABORATORY ANIMALS

The assessment of general well-being using spontaneous burrowing behaviour in a short-term model of chemotherapy-induced mucositis in the rat

(2014) A L Whittaker et al.   LABORATORY ANIMALS

Buprenorphine for pain relief in mice: repeated injections vs sustained-release depot formulation

(2014) P Jirkof et al.   LABORATORY ANIMALS

Assessment and refinement of intra-bone marrow transplantation in mice

(2014) U Pfeiffenberger et al.   LABORATORY ANIMALS

Using the mouse grimace scale to assess pain associated with routine ear notching and the effect of analgesia in laboratory mice

(2014) AL Miller et al.   LABORATORY ANIMALS

Positive animal welfare states and reference standards for welfare assessment

(2014) DJ Mellor   NEW ZEALAND VETERINARY JOURNAL

Hope for the Best or Prepare for the Worst? Towards a Spatial Cognitive Bias Test for Mice

(2014) Vanessa Kloke et al.   PLoS One

Sheltering Behavior and Locomotor Activity in 11 Genetically Diverse Common Inbred Mouse Strains Using Home-Cage Monitoring

(2014) Maarten Loos et al.   PLoS One

A Possible Link between Food and Mood: Dietary Impact on Gut Microbiota and Behavior in BALB/c Mice

(2014) Bettina Pyndt Jørgensen et al.   PLoS One

Housing of female mice in a new environment and its influence on post-surgical behaviour and recovery

(2013) Paulin Jirkof et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

Assessing the emotions of laboratory rats

(2013) I. Joanna Makowska et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: How are we progressing?

(2013) Alexandra L. Whittaker et al.   APPLIED ANIMAL BEHAVIOUR SCIENCE

Does exposure to chronic stress influence blood pressure in rats?

(2013) Larisa Bobrovskaya et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype

(2013) Vanessa Kloke et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic psychosocial stress makes rats more ‘pessimistic’ in the ambiguous-cue interpretation paradigm

(2013) Justyna Papciak et al.   BEHAVIOURAL BRAIN RESEARCH

Pharmacological validation of a refined burrowing paradigm for prediction of analgesic efficacy in a rat model of sub-chronic knee joint inflammation

(2013) K. Rutten et al.   EUROPEAN JOURNAL OF PAIN

Evaluation of cage leaving behaviour in rats as a free choice paradigm

(2013) B. Bert et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Cognitive bias in a non-human primate: husbandry procedures influence cognitive indicators of psychological well-being in captive rhesus macaques

(2012) EJ Bethell et al.   ANIMAL WELFARE

Social dimension of emotions and its implication for animal welfare

(2012) Marek Špinka   APPLIED ANIMAL BEHAVIOUR SCIENCE

Analgesia or Addiction?: Implications for Morphine Use after Spinal Cord Injury

(2012) Sarah A. Woller et al.   JOURNAL OF NEUROTRAUMA

Individual housing of female mice: influence on postsurgical behaviour and recovery

(2012) Paulin Jirkof et al.   LABORATORY ANIMALS

Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice

(2012) Klas S P Abelson et al.   LABORATORY ANIMALS

The Assessment of Post-Vasectomy Pain in Mice Using Behaviour and the Mouse Grimace Scale

(2012) Matthew C. Leach et al.   PLoS One

Laughing Rats Are Optimistic

(2012) Rafal Rygula et al.   PLoS One

The Rat Grimace Scale: A Partially Automated Method for Quantifying Pain in the Laboratory Rat via Facial Expressions

(2011) Susana G Sotocina et al.   Molecular Pain

The basic emotional circuits of mammalian brains: Do animals have affective lives?

(2011) Jaak Panksepp   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Defining animal welfare — does consistency matter?

(2011) MW Fisher   NEW ZEALAND VETERINARY JOURNAL

Extending ideas about animal welfare assessment to include ‘quality of life’ and related concepts

(2011) TC Green et al.   NEW ZEALAND VETERINARY JOURNAL

Animal welfare: At the interface between science and society

(2011) F. Ohl et al.   VETERINARY JOURNAL

Environmental enrichment induces optimistic cognitive bias in rats

(2010) Nichola M. Brydges et al.   ANIMAL BEHAVIOUR

An Improved Behavioural Assay Demonstrates That Ultrasound Vocalizations Constitute a Reliable Indicator of Chronic Cancer Pain and Neuropathic Pain

(2010) Martina Kurejova et al.   Molecular Pain

Coding of facial expressions of pain in the laboratory mouse

(2010) Dale J Langford et al.   NATURE METHODS

Frequency-modulated 50kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

(2010) Jeffrey Burgdorf et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Burrowing Behavior as an Indicator of Post-Laparotomy Pain in Mice

(2010) Paulin Jirkof et al.   Frontiers in Behavioral Neuroscience

The effects of stress on play and home cage behaviors in adolescent male rats

(2009) Zoe A. Klein et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice

(2009) J V Roughan et al.   LABORATORY ANIMALS

Measuring behavior in mice with chronic stress depression paradigm

(2009) Tatyana Strekalova et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic pain alters drug self-administration: Implications for addiction and pain mechanisms.

(2008) Thomas J. Martin et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY