RAS as Supporting Actor in Breast Cancer

Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

(2019) Tomoyo Okada et al.   NATURE CELL BIOLOGY

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

(2018) Felipe C. Geyer et al.   Nature Communications

Pharmacological targeting of RAS: Recent success with direct inhibitors

(2018) John P. O’Bryan   PHARMACOLOGICAL RESEARCH

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma

(2017) S Andò et al.   ONCOGENE

ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis

(2017) Linshan Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

Direct inhibition of RAS: Quest for the Holy Grail?

(2017) Russell Spencer-Smith et al.   SEMINARS IN CANCER BIOLOGY

BCL-XL directly modulates RAS signalling to favour cancer cell stemness

(2017) Sophie de Carné Trécesson et al.   Nature Communications

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program

(2016) Eleftheria Vasilaki et al.   Science Signaling

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis

(2016) Jar-Yi Ho et al.   Oncotarget

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program

(2016) Eleftheria Vasilaki et al.   Science Signaling

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients

(2015) K. L. Wright et al.   CANCER RESEARCH

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2015) S. Loi et al.   CLINICAL CANCER RESEARCH

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells

(2015) Long V. Nguyen et al.   NATURE

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation

(2015) Ze-Yi Zheng et al.   Cell Reports

Ras Promotes Transforming Growth Factor-β (TGF-β)-induced Epithelial-Mesenchymal Transition via a Leukotriene B4Receptor-2-linked Cascade in Mammary Epithelial Cells

(2014) Hyunju Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RASAL2 activates RAC1 to promote triple-negative breast cancer progression

(2014) Min Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

(2014) Tomoyo Okada et al.   NATURE CELL BIOLOGY

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

(2014) Romain M. Larive et al.   Nature Communications

The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor

(2013) Sara Koenig McLaughlin et al.   CANCER CELL

Single Copies of Mutant KRAS and Mutant PIK3CA Cooperate in Immortalized Human Epithelial Cells to Induce Tumor Formation

(2013) G. M. Wang et al.   CANCER RESEARCH

Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer

(2013) J. M. Balko et al.   CANCER RESEARCH

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2

(2013) C Choi et al.   ONCOGENE

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

(2012) Justin M Balko et al.   NATURE MEDICINE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 3′-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis

(2011) Trupti Paranjape et al.   LANCET ONCOLOGY

Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212

(2011) J. Jing et al.   MOLECULAR CANCER THERAPEUTICS

Ras-Induced Resistance to Lapatinib is Overcome by MEK Inhibition

(2010) G. Zoppoli et al.   CURRENT CANCER DRUG TARGETS

The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

(2010) X Zeng et al.   ONCOGENE

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

(2009) O. K. Mirzoeva et al.   CANCER RESEARCH

In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models

(2009) K. P. Hoeflich et al.   CLINICAL CANCER RESEARCH

Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

(2009) L. M. McGlynn et al.   CLINICAL CANCER RESEARCH

RCP is a human breast cancer–promoting gene with Ras-activating function

(2009) Jinqiu Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling

(2009) Yuliya Pylayeva et al.   JOURNAL OF CLINICAL INVESTIGATION

BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases

(2009) M J Hoenerhoff et al.   ONCOGENE

p21CIP1attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

(2009) Manran Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triple Negative Breast Carcinomas

(2009) Enrique Lerma et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

(2008) A. Swarbrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA