MAP4K Family Kinases and DUSP Family Phosphatases in T-Cell Signaling and Systemic Lupus Erythematosus

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

(2019) Lorna R. Fiedler et al.   Cell Stem Cell

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability

(2019) Hsueh-Fen Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual-Specificity Phosphatases in Immunity and Infection: An Update

(2019) Roland Lang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1

(2019) Huai-Chia Chuang et al.   CANCER RESEARCH

AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLKhighIL-17Ahigh subpopulation of systemic lupus erythematosus

(2019) Huai-Chia Chuang et al.   FASEB JOURNAL

cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus

(2019) Sigrun R. Hofmann et al.   JOURNAL OF IMMUNOLOGY

DUSP22 suppresses prostate cancer proliferation by targeting the EGFR-AR axis

(2019) Hsiu-Ping Lin et al.   FASEB JOURNAL

DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus

(2018) Juliana Imgenberg-Kreuz et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation

(2018) Chia-Yu Yang et al.   FASEB JOURNAL

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

(2018) Cynthia L. Hsu et al.   Nature Communications

DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation

(2018) Wei-Chan Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease

(2018) Huai-Chia Chuang et al.   Science Advances

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration

(2017) Y-R Chen et al.   ONCOGENE

TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity

(2016) Chia-Yu Yang et al.   CELLULAR SIGNALLING

DUSP23is over-expressed and linked to the expression ofDNMTsin CD4+T cells from systemic lupus erythematosus patients

(2016) E. Balada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumour necrosis factor-α inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation

(2016) Mark Corbett et al.   HEALTH TECHNOLOGY ASSESSMENT

Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus

(2016) Feifei Zhang et al.   JOURNAL OF AUTOIMMUNITY

A critical review of clinical trials in systemic lupus erythematosus

(2016) M A Mahieu et al.   LUPUS

Autoimmune diseases — connecting risk alleles with molecular traits of the immune system

(2016) Maria Gutierrez-Arcelus et al.   NATURE REVIEWS GENETICS

GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer

(2016) Chung-Ping Hsu et al.   Oncotarget

Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients

(2016) Huai-Chia Chuang et al.   Oncotarget

Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis

(2016) Huai-Chia Chuang et al.   Oncotarget

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

(2016) Cheng-Hsun Ho et al.   Oncotarget

A pathogenic IFNα, BLyS and IL-17 axis in Systemic Lupus Erythematosus patients

(2016) Patricia López et al.   Scientific Reports

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

T cells in the control of organ-specific autoimmunity

(2015) Jeffrey A. Bluestone et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome

(2015) Angad S Johar et al.   Journal of Translational Medicine

The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation

(2015) Dan Lu et al.   NATURE IMMUNOLOGY

Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization*

(2015) Wan-Yi Hsiao et al.   PLoS One

Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

(2014) Jérôme C. Martin et al.   CLINICAL IMMUNOLOGY

Dual-Specificity Phosphatase 14 (DUSP14/MKP6) Negatively Regulates TCR Signaling by Inhibiting TAB1 Activation

(2014) C.-Y. Yang et al.   JOURNAL OF IMMUNOLOGY

HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

(2014) Huai-Chia Chuang et al.   Nature Communications

The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck

(2014) Ju-Pi Li et al.   Nature Communications

Dual-Specificity Phosphatase 5 Attenuates Autoimmune Arthritis in Mice via Reciprocal Regulation of the Th17/Treg Cell Balance and Inhibition of Osteoclastogenesis

(2014) Su-Jin Moon et al.   Arthritis & Rheumatology

A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease

(2013) Malin Östensson et al.   PLoS One

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials

(2012) Susan Manzi et al.   ANNALS OF THE RHEUMATIC DISEASES

p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris

(2012) Athanasios Mavropoulos et al.   AUTOIMMUNITY REVIEWS

Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker

(2012) Der-Yuan Chen et al.   BMC Medicine

Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK)

(2012) Xiaohong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attenuation of T Cell Receptor Signaling by Serine Phosphorylation-mediated Lysine 30 Ubiquitination of SLP-76 Protein

(2012) Xiaohong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUSPs, to MAP kinases and beyond

(2012) Ching-Yu Huang et al.   Cell and Bioscience

DUSP4 deficiency enhances CD25 expression and CD4+T-cell proliferation without impeding T-cell development

(2011) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus

(2011) Qing Zhang et al.   JOURNAL OF AUTOIMMUNITY

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

(2011) Huai-Chia Chuang et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Resistance to MEK Inhibitors: Should We Co-Target Upstream?

(2011) P. I. Poulikakos et al.   Science Signaling

Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells

(2010) Mashael Al-Mutairi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus

(2010) Ana Henriques et al.   CELLULAR IMMUNOLOGY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Increased ERK and JNK activities correlate with disease activity in patients with systemic lupus erythematosus

(2009) Y Molad et al.   ANNALS OF THE RHEUMATIC DISEASES

"Go upstream, young man": lessons learned from the p38 saga

(2009) D Hammaker et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Key role of ERK pathway signaling in lupus

(2009) Gabriela Gorelik et al.   AUTOIMMUNITY

JNK Pathway-associated Phosphatase Dephosphorylates Focal Adhesion Kinase and Suppresses Cell Migration

(2009) Ju-Pi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MKP-1 Is Necessary for T Cell Activation and Function

(2009) Yongliang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selectivity and therapeutic inhibition of kinases: to be or not to be?

(2009) Kamran Ghoreschi et al.   NATURE IMMUNOLOGY

Overview of signal processing by the immune system in systemic lupus erythematosus

(2008) Andras Perl   AUTOIMMUNITY REVIEWS