The Impact of Oxidative Stress on Ribosomes: From Injury to Regulation

Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA

(2019) Takato Sugiyama et al.   Cell Reports

Maintenance of translational elongation rate underlies the survival of Escherichia coli during oxidative stress

(2019) Manlu Zhu et al.   NUCLEIC ACIDS RESEARCH

Ribosome Abundance Control Via the Ubiquitin–Proteasome System and Autophagy

(2019) Heeseon An et al.   JOURNAL OF MOLECULAR BIOLOGY

Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker’s yeast

(2019) William R. Blevins et al.   Scientific Reports

Polyubiquitin chains linked by lysine residue 48 (K48) selectively target oxidized proteins in vivo

(2019) Sandhya Manohar et al.   ANTIOXIDANTS & REDOX SIGNALING

Insights into the base-pairing preferences of 8-oxoguanosine on the ribosome

(2019) Erica N Thomas et al.   NUCLEIC ACIDS RESEARCH

Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeastSaccharomyces cerevisiae.

(2018) Jessica A. Zinskie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center

(2018) Jessica Willi et al.   NUCLEIC ACIDS RESEARCH

Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells

(2018) Da-Peng Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific binding of PCBP1 to heavily oxidized RNA to induce cell death

(2018) Takashi Ishii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

(2018) Caitlyn Q Herr et al.   TRENDS IN BIOCHEMICAL SCIENCES

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

(2018) Ulrike Topf et al.   Nature Communications

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life

(2018) Naomi R. Genuth et al.   MOLECULAR CELL

How to fold and protect mitochondrial ribosomal RNA with fewer guanines

(2018) Maryam Hosseini et al.   NUCLEIC ACIDS RESEARCH

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

(2018) David J. F. Ramrath et al.   SCIENCE

Site-Specific K63 Ubiquitinomics Provides Insights into Translation Regulation under Stress

(2018) Songhee Back et al.   JOURNAL OF PROTEOME RESEARCH

Multiple prebiotic metals mediate translation

(2018) Marcus S. Bray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease

(2018) Maria Daglas et al.   Frontiers in Neuroscience

Removal of oxidatively generated DNA damage by overlapping repair pathways

(2017) Vladimir Shafirovich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Nexus Implicated in Bowel Disease Pathophysiology

(2017) Wai Chong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endonucleolytic cleavage in the expansion segment 7 of 25S rRNA is an early marker of low-level oxidative stress in yeast

(2017) Daniel Shedlovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

(2017) Heeseon An et al.   NATURE CELL BIOLOGY

Oxidative stress, protein damage and repair in bacteria

(2017) Benjamin Ezraty et al.   NATURE REVIEWS MICROBIOLOGY

Biogenesis and iron-dependency of ribosomal RNA hydroxylation

(2017) Satoshi Kimura et al.   NUCLEIC ACIDS RESEARCH

ASC1 and RPS3 : new actors in 18S nonfunctional rRNA decay

(2017) Kelly A. Limoncelli et al.   RNA

The Hallmarks of Cancer from a Redox Perspective

(2016) Marten Hornsveld et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Quality control of chemically damaged RNA

(2016) Carrie L. Simms et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathways to Specialized Ribosomes: The Brussels Lecture

(2016) Jonathan D. Dinman   JOURNAL OF MOLECULAR BIOLOGY

Biophysical properties, thermal stability and functional impact of 8-oxo-7,8-dihydroguanine on oligonucleotides of RNA—a study of duplex, hairpins and the aptamer for preQ1as models

(2016) Yu J. Choi et al.   NUCLEIC ACIDS RESEARCH

Elucidation of pathways of ribosomal RNA degradation: an essential role for RNase E

(2016) Shaheen Sulthana et al.   RNA

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Oxidation of translation factor EF-G transiently retards the translational elongation cycle inEscherichia coli

(2015) Takanori Nagano et al.   JOURNAL OF BIOCHEMISTRY

Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

(2015) Salette Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localized control of oxidized RNA

(2015) Y. Zhan et al.   JOURNAL OF CELL SCIENCE

The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases

(2015) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins

(2015) Reneé Higgins et al.   MOLECULAR CELL

Oxidative stress conditions increase the frequency ofde novoformation of the yeast [PSI+] prion

(2015) Victoria A. Doronina et al.   MOLECULAR MICROBIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Redox proteomics: Methods for the identification and enrichment of redox-modified proteins and their applications

(2015) Claudia Lennicke et al.   PROTEOMICS

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses

(2015) Lauren Endres et al.   RNA Biology

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

(2015) Katja E. Menger et al.   Cell Reports

Thiol-based redox switches

(2014) Bastian Groitl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast

(2014) H. Huang et al.   EMBO JOURNAL

tRNA modifications regulate translation during cellular stress

(2014) Chen Gu et al.   FEBS LETTERS

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy

(2014) Batool Ossareh-Nazari et al.   JOURNAL OF CELL BIOLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

(2014) M. J. Katz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

(2014) C. Loenarz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Active Role for the Ribosome in Determining the Fate of Oxidized mRNA

(2014) Carrie L. Simms et al.   Cell Reports

tRNAs as regulators of biological processes

(2014) Medha Raina et al.   Frontiers in Genetics

Methionine oxidation and reduction in proteins

(2013) Geumsoo Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Proteome-wide profiling of carbonylated proteins and carbonylation sites in HeLa cells under mild oxidative stress conditions

(2013) Ravi Chand Bollineni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging

(2013) Martin A. Baraibar et al.   Journal of Proteomics

Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies

(2013) Maria Fedorova et al.   MASS SPECTROMETRY REVIEWS

Markers of oxidant stress that are clinically relevant in aging and age-related disease

(2013) Kimberly D. Jacob et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress

(2013) Andreas Czech et al.   PLoS Genetics

Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells

(2013) Zhongwei Li et al.   Wiley Interdisciplinary Reviews-RNA

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Characterization of RNA damage under oxidative stress in Escherichia coli

(2012) Min Liu et al.   BIOLOGICAL CHEMISTRY

Structural basis for protein synthesis: snapshots of the ribosome in motion

(2012) Jonas Noeske et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay

(2012) Kotaro Fujii et al.   EMBO JOURNAL

RNA modifications by oxidation: A novel disease mechanism?

(2012) Henrik E. Poulsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

(2012) Yasumitsu Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Cytoplasmic Turnover of Yeast Ribosomes in Response to Rapamycin Inhibition of TOR

(2012) D. G. Pestov et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

(2012) Daniela Knoefler et al.   MOLECULAR CELL

Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation

(2012) Asha Ivy Jacob et al.   MOLECULAR CELL

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

(2012) Wei Ge et al.   Nature Chemical Biology

One core, two shells: bacterial and eukaryotic ribosomes

(2012) Sergey Melnikov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

(2012) Akihiko Nunomura et al.   NEUROTOXICITY RESEARCH

RNA Folding and Catalysis Mediated by Iron (II)

(2012) Shreyas S. Athavale et al.   PLoS One

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

(2012) M. V. Gerashchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA inHaloferax volcanii

(2012) Jennifer Gebetsberger et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Methionine Oxidation of Sup35 Protein Induces Formation of the [PSI+] Prion in a Yeast Peroxiredoxin Mutant

(2011) Theodora C. Sideri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Quantitative Redox Proteomics to Dissect the Yeast Redoxome

(2011) Nicolas Brandes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometric characterization of peptides containing different oxidized tryptophan residues

(2011) Toni Todorovski et al.   JOURNAL OF MASS SPECTROMETRY

Identification of 5-Hydroxycytidine at Position 2501 Concludes Characterization of Modified Nucleotides in E. coli 23S rRNA

(2011) Jesper Foged Havelund et al.   JOURNAL OF MOLECULAR BIOLOGY

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

(2010) Hiroshi Hayakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative damage to RNA: mechanisms, consequences, and diseases

(2010) Qiongman Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

8-Oxo-7,8-dihydroguanine: Links to gene expression, aging, and defense against oxidative stress

(2010) Zsolt Radak et al.   FREE RADICAL BIOLOGY AND MEDICINE

An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe

(2010) Mikiei Tanaka et al.   FREE RADICAL RESEARCH

Proteomic Identification of Carbonylated Proteins and Their Oxidation Sites

(2010) Ashraf G. Madian et al.   JOURNAL OF PROTEOME RESEARCH

Severe oxidative stress induces protein mistranslation through impairment of an aminoacyl-tRNA synthetase editing site

(2010) J. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Protein Carbonylation

(2009) Yuichiro J. Suzuki et al.   ANTIOXIDANTS & REDOX SIGNALING

Polynucleotide Phosphorylase ProtectsEscherichia coliagainst Oxidative Stress†

(2009) Jinhua Wu et al.   BIOCHEMISTRY

A role for ubiquitin in the clearance of nonfunctional rRNAs

(2009) K. Fujii et al.   GENES & DEVELOPMENT

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

A Convergence of rRNA and mRNA Quality Control Pathways Revealed by Mechanistic Analysis of Nonfunctional rRNA Decay

(2009) Sarah E. Cole et al.   MOLECULAR CELL

Ribosome reactivation by replacement of damaged proteins

(2009) Arto Pulk et al.   MOLECULAR MICROBIOLOGY

Innate immune and chemically triggered oxidative stress modifies translational fidelity

(2009) Nir Netzer et al.   NATURE

The Phloem-Delivered RNA Pool Contains Small Noncoding RNAs and Interferes with Translation

(2009) S. Zhang et al.   PLANT PHYSIOLOGY

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress

(2008) Jinhua Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive oxygen species and yeast apoptosis

(2008) Gabriel G. Perrone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RNA under attack: Cellular handling of RNA damage

(2008) Elisabeth J. Wurtmann et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Ammonia induces RNA oxidation in cultured astrocytes and brainin vivo

(2008) Boris Görg et al.   HEPATOLOGY

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

(2008) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal

(2008) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Apoptotic signals induce specific degradation of ribosomal RNA in yeast

(2008) Seweryn Mroczek et al.   NUCLEIC ACIDS RESEARCH

Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

(2008) L. I. Leichert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA