IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy

TLR/MyD88/XBP1 signaling axis mediates skeletal muscle wasting during cancer cachexia

(2019) Kyle R. Bohnert et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival

(2019) Sarah Santiloni Cury et al.   Cancers

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer

(2018) Joshua K. Kays et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes

(2018) Ya-Chin Hou et al.   Journal of Clinical Medicine

A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer

(2017) Daniel Delitto et al.   SURGERY

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

(2017) Guohua Zhang et al.   Nature Communications

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC

(2017) Leong-Perng Chan et al.   Oncotarget

Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation

(2017) Huibin Tang et al.   Scientific Reports

Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture

(2016) Kien Pham et al.   AMERICAN JOURNAL OF PATHOLOGY

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment

(2016) Daniel Delitto et al.   CANCER RESEARCH

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

(2016) Justin L. Chen et al.   CANCER RESEARCH

A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia

(2015) Danielle N. Seto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary outgrowth cultures are a reliable source of human pancreatic stellate cells

(2015) Song Han et al.   LABORATORY INVESTIGATION

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

(2015) Sarah M Judge et al.   BMC CANCER

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

(2014) M. F. Sanmamed et al.   CLINICAL CANCER RESEARCH

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Diaphragm and ventilatory dysfunction during cancer cachexia

(2013) Brandon M. Roberts et al.   FASEB JOURNAL

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer

(2012) Adrian Britschgi et al.   CANCER CELL

Mice That Express Human Interleukin-8 Have Increased Mobilization of Immature Myeloid Cells, Which Exacerbates Inflammation and Accelerates Colon Carcinogenesis

(2012) Samuel Asfaha et al.   GASTROENTEROLOGY

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

(2011) Guohua Zhang et al.   EMBO JOURNAL

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

(2011) Sarah A. Reed et al.   FASEB JOURNAL

StellaTUM: current consensus and discussion on pancreatic stellate cell research

(2011) Mert Erkan et al.   GUT

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition

(2010) Fabio Penna et al.   PLoS One

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas—Implication for clinical evaluation of cancer patient

(2008) Malgorzata Krzystek-Korpacka et al.   CYTOKINE

Hsp70 overexpression inhibits NF-κB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy

(2008) Sarah M. Senf et al.   FASEB JOURNAL

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH