Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting

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HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

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C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-Independent

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Elevated nuclear Foxo1 suppresses excitability of skeletal muscle fibers

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Cancer cachexia decreases specific force and accelerates fatigue in limb muscle

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Diaphragm and ventilatory dysfunction during cancer cachexia

(2013) Brandon M. Roberts et al.   FASEB JOURNAL

NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia

(2013) Wei A. He et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrapleural Administration of AAV9 Improves Neural and Cardiorespiratory Function in Pompe Disease

(2013) Darin J Falk et al.   MOLECULAR THERAPY

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Collagen VI regulates satellite cell self-renewal and muscle regeneration

(2013) Anna Urciuolo et al.   Nature Communications

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

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Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia

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Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance

(2012) Margaret Dellett et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

(2012) Moon-Chang Choi et al.   MOLECULAR CELL

p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle

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C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

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Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

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STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

(2011) Andrea Bonetto et al.   PLoS One

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Ubiquilin at a crossroads in protein degradation pathways

(2010) Cara Rothenberg et al.   Autophagy

Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition

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FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70

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Muscle Interstitial Fibroblasts Are the Main Source of Collagen VI Synthesis in Skeletal Muscle: Implications for Congenital Muscular Dystrophy Types Ullrich and Bethlem

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

(2008) David S. Waddell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes

(2008) Yu Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer

(2008) Jeannine Bachmann et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Mice Lacking Homer 1 Exhibit a Skeletal Myopathy Characterized by Abnormal Transient Receptor Potential Channel Activity

(2008) J. A. Stiber et al.   MOLECULAR AND CELLULAR BIOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Mechano-regulated Tenascin-C orchestrates muscle repair

(2008) M. Fluck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA